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NADOLOL Drug Record

  • Summary
  • Interactions
  • Claims
  • NADOLOL chembl:CHEMBL649 Approved

    Alternate Names:

    CORGARD
    SQ-11725
    NADOLOL
    SOLGOL
    CORZIDE
    CORGARD®
    pubchem.compound:39147
    chemidplus:42200-33-9
    drugbank:01203
    chembl:CHEMBL649
    rxcui:7226

    Drug Info:

    Year of Approval 1979
    Drug Class anti-arrhythmia agents
    Drug Class antihypertensive agents
    FDA Approval 1979
    Drug Class small molecule
    Drug Indications Antihypertensive Agents
    Drug Indications Anti-Arrhythmia Agents
    (4 More Sources)

    Publications:

    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Wheeldon et al., 1994, The effects of lower than conventional doses of oral nadolol on relative beta 1/beta 2-adrenoceptor blockade., Br J Clin Pharmacol
    Liu et al., 1995, Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans., Int. J. Obes. Relat. Metab. Disord.
    Wheeldon et al., 1992, Evaluation of in vivo partial beta 1/beta 2-agonist activity: a dose-ranging study with carteolol., Br J Clin Pharmacol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Ozakca et al., 2007, Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats., Pharmacology
    Varma et al., 1999, Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium., Br. J. Pharmacol.
    Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.
    Varma, 1999, Ligand-independent negative chronotropic responses of rat and mouse right atria to beta-adrenoceptor antagonists., Can. J. Physiol. Pharmacol.
    Wheeldon et al., 1994, Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man., Br J Clin Pharmacol
    Koshiji et al., 1992, A comparison of guanfacine, bunazosin, atenolol and nadolol on blood pressure and plasma noradrenaline responses to cold pressor testing., Clin. Exp. Pharmacol. Physiol.
    Misaka S et al., 2014, Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects., Clin Pharmacol Ther
  • NADOLOL   SLCO1A2

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24419562


    Sources:
    PharmGKB

  • NADOLOL   ADRB1

    Interaction Score: 2.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-1 adrenergic receptor antagonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    10606440 7981009 7912539 1354084 11752352 10433496 2903243


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • NADOLOL   LPL

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1681747


    Sources:
    NCI

  • NADOLOL   ADRB2

    Interaction Score: 1.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    2903243 7981009 8574280 1349493 11752352 17622774 10433496


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • TEND: NADOLOL

    • Version: 01-August-2011

    Alternate Names:
    NADOLOL Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Drug Class anti-arrhythmia agents
    Year of Approval 1979

    Publications:

  • TdgClinicalTrial: NADOLOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-Arrhythmia Agents
    Drug Indications Antihypertensive Agents
    Drug Class small molecule

    Publications:

  • NCI: NADOLOL

    • Version: 14-September-2017

    Alternate Names:
    C29280 NCI drug code

    Drug Info:

    Publications:
    Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.

  • DTC: NADOLOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL649 ChEMBL Drug ID

    Drug Info:

    Publications:
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

  • PharmGKB: nadolol

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Misaka S et al., 2014, Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects., Clin Pharmacol Ther

  • TTD: Nadolol

    • Version: 2020.06.01

    Alternate Names:
    D05SHK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL649

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL649

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21