DGIdb - NADOLOL Drug Record

NADOLOL chembl:CHEMBL649 Approved

Alternate Names:

CORGARD
SQ-11725
NADOLOL
SOLGOL
CORZIDE
CORGARD®
pubchem.compound:39147
chemidplus:42200-33-9
drugbank:01203
chembl:CHEMBL649
rxcui:7226

Drug Info:

Year of Approval	1979
Drug Class	anti-arrhythmia agents
Drug Class	antihypertensive agents
FDA Approval	1979
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Indications	Anti-Arrhythmia Agents

(5 More Sources)

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Wheeldon et al., 1994, The effects of lower than conventional doses of oral nadolol on relative beta 1/beta 2-adrenoceptor blockade., Br J Clin Pharmacol
Liu et al., 1995, Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans., Int. J. Obes. Relat. Metab. Disord.
Wheeldon et al., 1992, Evaluation of in vivo partial beta 1/beta 2-agonist activity: a dose-ranging study with carteolol., Br J Clin Pharmacol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ozakca et al., 2007, Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats., Pharmacology
Varma et al., 1999, Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium., Br. J. Pharmacol.
Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.
Varma, 1999, Ligand-independent negative chronotropic responses of rat and mouse right atria to beta-adrenoceptor antagonists., Can. J. Physiol. Pharmacol.
Wheeldon et al., 1994, Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man., Br J Clin Pharmacol
Koshiji et al., 1992, A comparison of guanfacine, bunazosin, atenolol and nadolol on blood pressure and plasma noradrenaline responses to cold pressor testing., Clin. Exp. Pharmacol. Physiol.
Misaka S et al., 2014, Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects., Clin Pharmacol Ther

NADOLOL SLCO1A2

Interaction Score: 3.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24419562

Sources:
PharmGKB
NADOLOL ADRB1

Interaction Score: 1.8

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
10606440 7981009 7912539 1354084 11752352 10433496 2903243

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
NADOLOL LPL

Interaction Score: 1.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1681747

Sources:
NCI
NADOLOL ADRB2

Interaction Score: 1.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
2903243 7981009 8574280 1349493 11752352 17622774 10433496

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
NADOLOL ADRB3

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology

TEND: NADOLOL
- Version: 01-August-2011
Alternate Names:

NADOLOL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class anti-arrhythmia agents

Year of Approval 1979

Publications:
TdgClinicalTrial: NADOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Publications:
NCI: NADOLOL
- Version: 14-September-2017
Alternate Names:

C29280 NCI drug code

Drug Info:

Publications:

Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.
DTC: NADOLOL
- Version: 02-September-2020
Alternate Names:

CHEMBL649 ChEMBL Drug ID

Drug Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
PharmGKB: nadolol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Misaka S et al., 2014, Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects., Clin Pharmacol Ther
TTD: Nadolol
- Version: 2020.06.01
Alternate Names:

D05SHK TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650678
- Version: 29-September-2020
Alternate Names:

NADOLOL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL649
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL649
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

NADOLOL Drug Record

NADOLOL chembl:CHEMBL649 Approved

Alternate Names:

Drug Info:

Publications:

NADOLOL SLCO1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24419562

Sources: PharmGKB

NADOLOL ADRB1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 10606440 7981009 7912539 1354084 11752352 10433496 2903243

Sources: DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

NADOLOL LPL

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1681747

Sources: NCI

NADOLOL ADRB2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: 2903243 7981009 8574280 1349493 11752352 17622774 10433496

Sources: DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

NADOLOL ADRB3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: None found

Sources: GuideToPharmacology

TEND: NADOLOL

Alternate Names: NADOLOL Primary Drug Name

Drug Info: Drug Class antihypertensive agents Drug Class anti-arrhythmia agents Year of Approval 1979

Publications:

TdgClinicalTrial: NADOLOL

Alternate Names:

Drug Info: Drug Indications Anti-Arrhythmia Agents Drug Indications Antihypertensive Agents Drug Class small molecule

Publications:

NCI: NADOLOL

Alternate Names: C29280 NCI drug code

Drug Info:

Publications: Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.

DTC: NADOLOL

Alternate Names: CHEMBL649 ChEMBL Drug ID

Drug Info:

Publications: el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

PharmGKB: nadolol

Alternate Names:

Drug Info:

Publications: Misaka S et al., 2014, Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects., Clin Pharmacol Ther

TTD: Nadolol

Alternate Names: D05SHK TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 135650678

Alternate Names: NADOLOL GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL649

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL649

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
24419562

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
10606440 7981009 7912539 1354084 11752352 10433496 2903243

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
1681747

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
2903243 7981009 8574280 1349493 11752352 17622774 10433496

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology

Alternate Names:

NADOLOL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class anti-arrhythmia agents

Year of Approval 1979

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Alternate Names:

C29280 NCI drug code

Publications:

Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.

Alternate Names:

CHEMBL649 ChEMBL Drug ID

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

Publications:

Misaka S et al., 2014, Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects., Clin Pharmacol Ther

Alternate Names:

D05SHK TTD Drug ID

Alternate Names:

NADOLOL GuideToPharmacology Ligand Name