DGIdb - NAPROXEN Drug Record

NAPROXEN chembl:CHEMBL154 Approved

Alternate Names:

GRENOXAL
RHEUFLEX 250
ANAPROX
NAPRATEC OP
ARTHROSIN 250 EC
EQUIPROXEN
NAPROSYN
STIRLESCENT
ARTHROSIN 500
TIMPRON 500 EC
VALROX
TIMPRON
CONDROTEC
NAPROXEN
NAPRELAN
VIMOVO
TIMPRON 250 EC
NAPROSYN EC
RS-3540
ALEVE
PRANOXEN CONTINUS
NYCOPREN
KENOSYN
EC-NAPROSYN
FEMINAX ULTRA
ARTHROSIN 250
LARAFLEX
RHEUFLEX 500
NAPROSYN 375
PROSAID
RIMOXYN
ARTHROSIN 500 EC
NOVONAPROX
NAPROLAG
D-NAPROXEN
(+)-(S)-6-METHOXY-Α-METHYL-2-NAPHTHALENEACETIC ACID
FLOGINAX
NAPROXENO
(S)-NAPROXEN
NAPROSYNE
DL NAPROXEN
ACUSPRAIN
2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID
NAPFLAM
(+)-NAPROXEN
GENOXEN
NAPMEL
(+)-2-(METHOXY-2-NAPHTHYL)-PROPIONSÄURE
NAPROXEN SODIUM
NAPOSIN
ANEXOPEN
ARTHRISIL
LENIARTIL
(S)-(+)-NAPROXEN
(+)-(S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID
ALEVE®
NALYXAN
ARTRIXEN
ARTROXEN
DYSMENALGIT
(+)-(S)-NAPROXEN
NAPROXENUM
DUK
FLEXIPEN
NAPROXÈNE
(S)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID
(+)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID
DANAPROX
LEFAINE
ARTAGEN
NAIXAN
FUXEN
CALOSEN
DYSMENALGIT N
DAPROX
BIPRONYL
AXER
(S)-(+)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID
(S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID
DL-NAPROXEN
CONGEX
CLINOSYN
NAPROXENE
(+)-2-(METHOXY-2-NAPHTHYL)-PROPIONIC ACID
DIOCODAL
NAPROSY®
OPIPRAMOL
APRONAX
ATIFLAN
(S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOIC ACID
NAFASOL
rxcui:7258
drugbank:00788
chemidplus:22204-53-1
chembl:CHEMBL154
pubchem.compound:156391

Drug Info:

Drug Indications	NSAID
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antimigraine agent
Drug Class	anti-inflammatory agents
Year of Approval	1976

(4 More Sources)

Publications:

James et al., 2007, Selective COX-2 inhibitors, eicosanoid synthesis and clinical outcomes: a case study of system failure., Lipids
Brutzkus JC et al., 2020, Naproxen,
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Tracy et al., 1997, Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation., Eur. J. Clin. Pharmacol.
Barthwal et al., 1991, Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta)., Adv Contracept
Albertini et al., 2007, COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy., Inflamm. Res.
Kumar et al., 2007, Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms., Fundam Clin Pharmacol
Dhir et al., 2007, Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice., Seizure
White, 2007, Cardiovascular effects of the selective cyclooxygenase-2 inhibitors., Subcell. Biochem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hassan-Alin et al., 2005, Lack of Pharmacokinetic Interaction between Esomeprazole and the Nonsteroidal Anti-Inflammatory Drugs Naproxen and Rofecoxib in Healthy Subjects., Clin Drug Investig
Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
Ikenoue et al., 2000, Disease-induced alterations in plasma drug-binding proteins and their influence on drug binding percentages in dogs., Vet Q
Sipe et al., 1992, Modification of proinflammatory cytokine production by the antirheumatic agents tenidap and naproxen. A possible correlate with clinical acute phase response., J. Immunol.
Shiotani et al., 2002, NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite., Dig. Dis. Sci.
van Dijk et al., 2004, Potential interaction between acenocoumarol and diclofenac, naproxen and ibuprofen and role of CYP2C9 genotype., Thromb. Haemost.

NAPROXEN SAA1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1729367

Sources:
NCI
NAPROXEN PLAT

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1908176

Sources:
NCI
NAPROXEN PTGS2

Interaction Score: 0.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MT 100

Novel drug target Established target

Trial Name MT 400,Treximet

PMIDs:
17607546 17521299 17604186 17612049 11752352 17532719 19602986 30247840

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
NAPROXEN PTGS1

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

Trial Name MT 100

PMIDs:
17541796 30247840

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
NAPROXEN ALB

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10682387

Sources:
NCI
NAPROXEN CXCL8

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11852880

Sources:
NCI
NAPROXEN CYP2C9

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14691574 22931300

Sources:
DTC NCI
NAPROXEN CYP1A2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 9248768

Sources:
DTC NCI
NAPROXEN CBX1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NAPROXEN CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NAPROXEN CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NAPROXEN CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TdgClinicalTrial: NAPROXEN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Publications:
TEND: NAPROXEN
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 1976

Drug Class anti-inflammatory agents

Publications:

NCI: NAPROXEN

Version: 14-September-2017

Alternate Names:

C680 NCI drug code

Drug Info:

Publications:

Shiotani et al., 2002, NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite., Dig. Dis. Sci.

Ikenoue et al., 2000, Disease-induced alterations in plasma drug-binding proteins and their influence on drug binding percentages in dogs., Vet Q

Tracy et al., 1997, Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation., Eur. J. Clin. Pharmacol.

DTC: NAPROXEN
- Version: 02-September-2020
Alternate Names:

CHEMBL154 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
PharmGKB: naproxen
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
TTD: Naproxen
- Version: 2020.06.01
Alternate Names:

D0DJ1B TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL154
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL154
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	MT 100
Novel drug target	Established target
Trial Name	MT 400,Treximet

Direct Interaction	yes
Mechanism of Interaction	Cyclooxygenase inhibitor
Trial Name	MT 100

NAPROXEN Drug Record

NAPROXEN chembl:CHEMBL154 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1729367

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1908176

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MT 100 Novel drug target Established target Trial Name MT 400,Treximet

PMIDs: 17607546 17521299 17604186 17612049 11752352 17532719 19602986 30247840

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclooxygenase inhibitor Trial Name MT 100

PMIDs: 17541796 30247840

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10682387

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11852880

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14691574 22931300

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300 9248768

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TdgClinicalTrial: NAPROXEN

Alternate Names:

Drug Info: Drug Indications antimigraine agent Drug Class Small Molecule FDA Approval approved

Publications:

TEND: NAPROXEN

Alternate Names:

Drug Info: Year of Approval 1976 Drug Class anti-inflammatory agents

Publications:

NCI: NAPROXEN

Alternate Names: C680 NCI drug code

Drug Info:

DTC: NAPROXEN

Alternate Names: CHEMBL154 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: naproxen

Alternate Names:

Drug Info:

Publications: Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

TTD: Naproxen

Alternate Names: D0DJ1B TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL154

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
1729367

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1908176

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MT 100

Novel drug target Established target

Trial Name MT 400,Treximet

PMIDs:
17607546 17521299 17604186 17612049 11752352 17532719 19602986 30247840

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

Trial Name MT 100

PMIDs:
17541796 30247840

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
10682387

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11852880

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14691574 22931300

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
22931300 9248768

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Drug Info:

Year of Approval 1976

Drug Class anti-inflammatory agents

Alternate Names:

C680 NCI drug code

Alternate Names:

CHEMBL154 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Publications:

Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

Alternate Names:

D0DJ1B TTD Drug ID