• Interaction Score: 2.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Apoptosis regulator Bcl-W inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 2.66

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor
    Direct Interaction yes
    Notes

    PMIDs:
    None found


  • Interaction Score: 0.72

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy ABT-263 + Alpelisib + Dabrafenib + Erlotinib
    Indication/Tumor Type colorectal cancer
    Response Type sensitive


    Sources:
    JAX-CKB

  • Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Approval Status Preclinical
    Indication/Tumor Type non-small cell lung carcinoma
    combination therapy Trametinib + Navitoclax


    Sources:
    JAX-CKB

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Navitoclax + ONC201
    Indication/Tumor Type glioblastoma multiforme
    Response Type sensitive

    PMIDs:
    26474387


    Sources:
    JAX-CKB

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell line xenograft
    Response Type predicted – sensitive


    Sources:
    JAX-CKB

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Navitoclax + ONC201
    Indication/Tumor Type glioblastoma multiforme
    Response Type sensitive


    Sources:
    JAX-CKB

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC