DGIdb - NEFAZODONE Drug Record

NEFAZODONE chembl:CHEMBL623 Approved

Alternate Names:

NEFAZODONE
MJ-13754-1
1-(3-(4-(M-CHLOROPHENYL)-1-PIPERAZINYL)PROPYL)-3-ETHYL-4-(2-PHENOXYETHYL)-DELTA2-1,2,4-TRIAZOLIN-5-ONE
NEFAZODONUM
NEFAZODONA
BMY-13754
NEFADAR®
chemidplus:83366-66-9
rxcui:31565
pubchem.compound:4449
drugbank:01149
chembl:CHEMBL623

Drug Info:

FDA Approval	1994
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Second-Generation
Drug Class	antidepressive agents, second-generation
Year of Approval	1994

(2 More Sources)

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Taylor et al., 1995, Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug., J Clin Psychiatry
Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
Davis et al., 1997, Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression., Drugs
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Narayan et al., 1998, Serotonin transporter-blocking properties of nefazodone assessed by measurement of platelet serotonin., J Clin Psychopharmacol
Owens et al., 1995, The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies., Life Sci.
Eckler et al., 2003, Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control., Pharmacol. Biochem. Behav.
Hidalgo et al., 1999, Nefazodone in post-traumatic stress disorder: results from six open-label trials., Int Clin Psychopharmacol
Avila et al., 2003, Does nefazodone improve both depression and Parkinson disease? A pilot randomized trial., J Clin Psychopharmacol
Horton et al., 1999, Akinetopsia from nefazodone toxicity., Am. J. Ophthalmol.
Meyer et al., 1999, The effects of single dose nefazodone and paroxetine upon 5-HT2A binding potential in humans using [18F]-setoperone PET., Psychopharmacology (Berl.)
Millan, Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies., Therapie
Owen et al., 1999, Norepinephrine transporter gene polymorphism is not associated with susceptibility to major depression., Psychiatry Res
Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
Sarginson JE et al., 2010, FKBP5 polymorphisms and antidepressant response in geriatric depression., Am J Med Genet B Neuropsychiatr Genet
Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet

NEFAZODONE FKBP5

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB
NEFAZODONE SLC6A2

Interaction Score: 1.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9098663 9537821 7649970 10512149 7475971

Sources:
TdgClinicalTrial TEND
NEFAZODONE SLC6A4

Interaction Score: 0.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
9098663 9537821 7649970 9472845 7475971

Sources:
TdgClinicalTrial TEND
NEFAZODONE HTR2A

Interaction Score: 0.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7855217 12873632 10220119 9098663 14520130 10577608 7649970 10435395

Sources:
TdgClinicalTrial TEND
NEFAZODONE ADRA1B

Interaction Score: 0.52

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND
NEFAZODONE HTR1B

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
NEFAZODONE HTR2C

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
16433010 11752352

Sources:
TTD
NEFAZODONE ADRA1A

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7855217 7649970

Sources:
TdgClinicalTrial TEND
NEFAZODONE ABCB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
NEFAZODONE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA

TEND: NEFAZODONE
- Version: 01-August-2011
Alternate Names:

NEFAZODONE Primary Drug Name

Drug Info:

Year of Approval 1994

Drug Class antidepressive agents, second-generation

Publications:
TdgClinicalTrial: NEFAZODONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents, Second-Generation

Drug Class small molecule

FDA Approval 1994

Publications:

PharmGKB: nefazodone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics

Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics

Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett

TTD: Nefazodone
- Version: 2020.06.01
Alternate Names:

D0X7DE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL623
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Nefazodone
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

NEFAZODONE Drug Record

NEFAZODONE chembl:CHEMBL623 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9098663 9537821 7649970 10512149 7475971

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 9098663 9537821 7649970 9472845 7475971

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7855217 12873632 10220119 9098663 14520130 10577608 7649970 10435395

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21449676

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 16433010 11752352

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 7855217 7649970

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21449676

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

TEND: NEFAZODONE

Alternate Names: NEFAZODONE Primary Drug Name

Drug Info: Year of Approval 1994 Drug Class antidepressive agents, second-generation

Publications:

TdgClinicalTrial: NEFAZODONE

Alternate Names:

Drug Info: Drug Indications Antidepressive Agents, Second-Generation Drug Class small molecule FDA Approval 1994

Publications:

PharmGKB: nefazodone

Alternate Names:

Drug Info:

TTD: Nefazodone

Alternate Names: D0X7DE TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL623

Alternate Names:

Drug Info:

Publications:

FDA: Nefazodone

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9098663 9537821 7649970 10512149 7475971

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
9098663 9537821 7649970 9472845 7475971

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7855217 12873632 10220119 9098663 14520130 10577608 7649970 10435395

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
21449676

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
16433010 11752352

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7855217 7649970

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
21449676

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Alternate Names:

NEFAZODONE Primary Drug Name

Drug Info:

Year of Approval 1994

Drug Class antidepressive agents, second-generation

Drug Info:

Drug Indications Antidepressive Agents, Second-Generation

Drug Class small molecule

FDA Approval 1994

Alternate Names:

D0X7DE TTD Drug ID