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NEFAZODONE Drug Record

  • Summary
  • Interactions
  • Claims
  • NEFAZODONE chembl:CHEMBL623 Approved

    Alternate Names:

    NEFAZODONE
    MJ-13754-1
    1-(3-(4-(M-CHLOROPHENYL)-1-PIPERAZINYL)PROPYL)-3-ETHYL-4-(2-PHENOXYETHYL)-DELTA2-1,2,4-TRIAZOLIN-5-ONE
    NEFAZODONUM
    NEFAZODONA
    BMY-13754
    NEFADAR®
    chemidplus:83366-66-9
    rxcui:31565
    pubchem.compound:4449
    drugbank:01149
    chembl:CHEMBL623

    Drug Info:

    FDA Approval 1994
    Drug Class small molecule
    Drug Indications Antidepressive Agents, Second-Generation
    Drug Class antidepressive agents, second-generation
    Year of Approval 1994
    (2 More Sources)

    Publications:

    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Taylor et al., 1995, Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug., J Clin Psychiatry
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Davis et al., 1997, Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression., Drugs
    Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
    Narayan et al., 1998, Serotonin transporter-blocking properties of nefazodone assessed by measurement of platelet serotonin., J Clin Psychopharmacol
    Owens et al., 1995, The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies., Life Sci.
    Eckler et al., 2003, Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control., Pharmacol. Biochem. Behav.
    Hidalgo et al., 1999, Nefazodone in post-traumatic stress disorder: results from six open-label trials., Int Clin Psychopharmacol
    Avila et al., 2003, Does nefazodone improve both depression and Parkinson disease? A pilot randomized trial., J Clin Psychopharmacol
    Horton et al., 1999, Akinetopsia from nefazodone toxicity., Am. J. Ophthalmol.
    Meyer et al., 1999, The effects of single dose nefazodone and paroxetine upon 5-HT2A binding potential in humans using [18F]-setoperone PET., Psychopharmacology (Berl.)
    Millan, Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies., Therapie
    Owen et al., 1999, Norepinephrine transporter gene polymorphism is not associated with susceptibility to major depression., Psychiatry Res
    Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
    Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
    Sarginson JE et al., 2010, FKBP5 polymorphisms and antidepressant response in geriatric depression., Am J Med Genet B Neuropsychiatr Genet
    Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
    Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
    Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
  • NEFAZODONE   FKBP5

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 21449676 20709156 19676097 18597649 17467808 15565110


    Sources:
    PharmGKB

  • NEFAZODONE   SLC6A2

    Interaction Score: 1.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9098663 9537821 7649970 10512149 7475971


    Sources:
    TdgClinicalTrial TEND

  • NEFAZODONE   SLC6A4

    Interaction Score: 0.83

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    9098663 9537821 7649970 9472845 7475971


    Sources:
    TdgClinicalTrial TEND

  • NEFAZODONE   HTR2A

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7855217 12873632 10220119 9098663 14520130 10577608 7649970 10435395


    Sources:
    TdgClinicalTrial TEND

  • NEFAZODONE   ADRA1B

    Interaction Score: 0.52

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 11752352


    Sources:
    TdgClinicalTrial TEND

  • NEFAZODONE   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • NEFAZODONE   HTR2C

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    16433010 11752352


    Sources:
    TTD

  • NEFAZODONE   ADRA1A

    Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7855217 7649970


    Sources:
    TdgClinicalTrial TEND

  • NEFAZODONE   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • NEFAZODONE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TEND: NEFAZODONE

    • Version: 01-August-2011

    Alternate Names:
    NEFAZODONE Primary Drug Name

    Drug Info:
    Year of Approval 1994
    Drug Class antidepressive agents, second-generation

    Publications:

  • TdgClinicalTrial: NEFAZODONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antidepressive Agents, Second-Generation
    Drug Class small molecule
    FDA Approval 1994

    Publications:

  • PharmGKB: nefazodone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
    Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett

  • TTD: Nefazodone

    • Version: 2020.06.01

    Alternate Names:
    D0X7DE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL623

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Nefazodone

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21