DGIdb - NEFLAMAPIMOD Drug Record

NEFLAMAPIMOD chembl:CHEMBL119385

Alternate Names:

VD-31,745
VRT-031745
VD-31745
VX-745
NEFLAMAPIMOD
745
VD-31

Drug Info:

(1 More Sources)

Publications:

Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Duffy JP et al., 2011, The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor., ACS Med Chem Lett

NEFLAMAPIMOD MAP2K6

Interaction Score: 1.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NEFLAMAPIMOD MAPK14

Interaction Score: 1.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
17659871 10592235 24900264

Sources:
DTC ChemblInteractions GuideToPharmacology TTD
NEFLAMAPIMOD MAPK11

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD
NEFLAMAPIMOD MAPK12

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NEFLAMAPIMOD ROS1

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: VX-745
- Version: 02-September-2020
Alternate Names:

CHEMBL119385 ChEMBL Drug ID

Drug Info:

Publications:

Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett
TTD: VX-745
- Version: 2020.06.01
Alternate Names:

D02NNV TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178102345
- Version: 29-September-2020
Alternate Names:

NEFLAMAPIMOD GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblInteractions: CHEMBL119385
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL119385
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	MAP kinase p38 alpha inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

NEFLAMAPIMOD Drug Record

NEFLAMAPIMOD chembl:CHEMBL119385

Alternate Names:

Drug Info:

Publications:

NEFLAMAPIMOD MAP2K6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

NEFLAMAPIMOD MAPK14

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 alpha inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 17659871 10592235 24900264

Sources: DTC ChemblInteractions GuideToPharmacology TTD

NEFLAMAPIMOD MAPK11

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology TTD

NEFLAMAPIMOD MAPK12

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

NEFLAMAPIMOD ROS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DTC: VX-745

Alternate Names: CHEMBL119385 ChEMBL Drug ID

Drug Info:

Publications: Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett

TTD: VX-745

Alternate Names: D02NNV TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178102345

Alternate Names: NEFLAMAPIMOD GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblInteractions: CHEMBL119385

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL119385

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 alpha inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
17659871 10592235 24900264

Sources:
DTC ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL119385 ChEMBL Drug ID

Publications:

Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett

Alternate Names:

D02NNV TTD Drug ID

Alternate Names:

NEFLAMAPIMOD GuideToPharmacology Ligand Name