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NEFLAMAPIMOD Drug Record

  • Summary
  • Interactions
  • Claims
  • NEFLAMAPIMOD chembl:CHEMBL119385

    Alternate Names:

    VD-31,745
    VRT-031745
    VD-31745
    VX-745
    NEFLAMAPIMOD
    745
    VD-31

    Drug Info:

    (0 More Sources)

    Publications:

    Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Duffy JP et al., 2011, The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor., ACS Med Chem Lett
  • NEFLAMAPIMOD   MAP2K6

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NEFLAMAPIMOD   MAPK14

    Interaction Score: 1.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction MAP kinase p38 alpha inhibitor
    Direct Interaction yes

    PMIDs:
    17659871 10592235 24900264


    Sources:
    DTC ChemblInteractions TTD

  • NEFLAMAPIMOD   MAPK11

    Interaction Score: 0.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NEFLAMAPIMOD   MAPK12

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NEFLAMAPIMOD   ROS1

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DTC: VX-745

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL119385 ChEMBL Drug ID

    Drug Info:

    Publications:
    Bagley MC et al., 2007, Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells., Bioorg Med Chem Lett

  • TTD: VX-745

    • Version: 2020.06.01

    Alternate Names:
    D02NNV TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL119385

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL119385

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21