DGIdb - NELFINAVIR Drug Record

NELFINAVIR chembl:CHEMBL584 ApprovedAntineoplastic

Alternate Names:

VIRACEPT
NELFINAVIR
drugbank:00220
pubchem.compound:64143
chembl:CHEMBL584
rxcui:134527
chemidplus:159989-64-7

Drug Info:

(1 More Sources)

Publications:

Lenhard et al., 2000, HIV protease inhibitors block adipogenesis and increase lipolysis in vitro., Antiviral Res.
Tong L et al., 2007, Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro., Antimicrob Agents Chemother
Mukonzo JK et al., 2013, Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: a prospective cohort study., BMC Infect Dis
Elens L et al., 2010, Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients., Pharmacogenomics
Ribaudo HJ et al., 2010, Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study., J Infect Dis
Ritchie MD et al., 2006, Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity., Clin Infect Dis
Haas DW et al., 2005, Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study., J Infect Dis
Fellay J et al., 2002, Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study., Lancet
Equils et al., 2004, Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation., Antimicrob. Agents Chemother.
Kattel K et al., 2015, Impact of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir in patients with pancreatic cancer., Br J Clin Pharmacol

NELFINAVIR TFAP2A

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10996400

Sources:
NCI
NELFINAVIR TLR4

Interaction Score: 1.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15388451

Sources:
NCI
NELFINAVIR IL6

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15388451

Sources:
NCI
NELFINAVIR ABCB1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17664327 23734829 20860463 20662624 16912956 16267764 11809184

Sources:
DTC PharmGKB
NELFINAVIR AKT1

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
NELFINAVIR CYP2C19

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25752914 16267764

Sources:
PharmGKB
NELFINAVIR CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

NCI: NELFINAVIR

Version: 14-September-2017

Alternate Names:

C29285 NCI drug code

Drug Info:

Publications:

Lenhard et al., 2000, HIV protease inhibitors block adipogenesis and increase lipolysis in vitro., Antiviral Res.

Equils et al., 2004, Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation., Antimicrob. Agents Chemother.

DTC: NELFINAVIR
- Version: 02-September-2020
Alternate Names:

CHEMBL584 ChEMBL Drug ID

Drug Info:

Publications:

Tong L et al., 2007, Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro., Antimicrob Agents Chemother

PharmGKB: nelfinavir

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Ribaudo HJ et al., 2010, Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study., J Infect Dis

Elens L et al., 2010, Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients., Pharmacogenomics

Fellay J et al., 2002, Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study., Lancet

TALC: NELFINAVIR
- Version: 12-May-2016
Alternate Names:

NELFINAVIR Primary Drug Name

NELFINAVIR Drug Generic Name

VIRACEPT Drug Trade Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL584
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

NELFINAVIR	Primary Drug Name
NELFINAVIR	Drug Generic Name
VIRACEPT	Drug Trade Name

NELFINAVIR Drug Record

NELFINAVIR chembl:CHEMBL584 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

NELFINAVIR TFAP2A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10996400

Sources: NCI

NELFINAVIR TLR4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15388451

Sources: NCI

NELFINAVIR IL6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15388451

Sources: NCI

NELFINAVIR ABCB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17664327 23734829 20860463 20662624 16912956 16267764 11809184

Sources: DTC PharmGKB

NELFINAVIR AKT1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: None found

Sources: TALC

NELFINAVIR CYP2C19

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25752914 16267764

Sources: PharmGKB

NELFINAVIR CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

NCI: NELFINAVIR

Alternate Names: C29285 NCI drug code

Drug Info:

DTC: NELFINAVIR

Alternate Names: CHEMBL584 ChEMBL Drug ID

Drug Info:

Publications: Tong L et al., 2007, Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro., Antimicrob Agents Chemother

PharmGKB: nelfinavir

Alternate Names:

Drug Info:

TALC: NELFINAVIR

Alternate Names: NELFINAVIR Primary Drug Name NELFINAVIR Drug Generic Name VIRACEPT Drug Trade Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL584

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10996400

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15388451

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15388451

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17664327 23734829 20860463 20662624 16912956 16267764 11809184

Sources:
DTC PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

n/a

PMIDs:
25752914 16267764

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

C29285 NCI drug code

Alternate Names:

CHEMBL584 ChEMBL Drug ID

Publications:

Tong L et al., 2007, Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro., Antimicrob Agents Chemother

Alternate Names:

NELFINAVIR Primary Drug Name

NELFINAVIR Drug Generic Name

VIRACEPT Drug Trade Name