NIQUITIN MINIS ORANGE |
NICABATE |
NIQUITIN |
STUBIT |
NICOTROL |
NICOTROL NS |
NICOTINELL TTS 30 |
NICOPASS |
NICOTINE |
NICORETTE INVISI |
NICOTINELL SUPPORT |
NIQUITIN MINIS CHERRY |
NIQUITIN PRE-QUIT |
NICOPATCH |
NICOTINELL TTS 20 |
NIQUITIN CLR |
STOPPERS |
NICOTINELL CLASSIC |
NIQUITIN MINIS MINT |
NICODERM CQ |
NICOTINELL TTS 10 |
NICOTROL INHALER |
NIQUITIN MINT |
NIQUITIN STRIPS MINT |
PROSTEP |
HABITROL |
NICODERM |
Year of Approval | 1996 |
Drug Class | central nervous system stimulants |
FDA Approval | 1996 |
Drug Class | small molecule |
Drug Indications | Central Nervous System Stimulants |
Drug Categories | ganglionic stimulants |
Drug Categories | drugs used in nicotine dependence |
Drug Categories | drugs used in addictive disorders |
Drug Categories | cytochrome p-450 cyp2e1 inhibitors (moderate) |
Drug Categories | cytochrome p-450 cyp1a2 inducers |
Drug Categories | agents producing tachycardia |
Drug Categories | cholinergic nicotinic agonist |
Drug Categories | cytochrome p-450 cyp1a2 inducers (strength unknown) |
Drug Categories | cytochrome p-450 cyp2a6 inhibitors (strength unknown) |
Drug Categories | cytochrome p-450 cyp2e1 inducers |
Drug Categories | cytochrome p-450 cyp2e1 inducers (strength unknown) |
Drug Categories | cytochrome p-450 cyp2e1 inhibitors (strength unknown) |
Drug Categories | cytochrome p-450 cyp3a substrates |
Drug Categories | cytochrome p-450 enzyme inducers |
Drug Categories | cytochrome p-450 enzyme inhibitors |
Drug Categories | cytochrome p-450 substrates |
Drug Categories | ganglion blockers |
Drug Categories | miscellaneous autonomic drugs |
Drug Categories | monoamine oxidase a inhibitors for interaction with monoamine oxidase a substrates |
Drug Categories | nicotine, antagonists & inhibitors |
Drug Categories | nicotine, metabolism |
Drug Categories | oct1 inhibitors |
Drug Categories | oct2 inhibitors |
Drug Categories | smoking cessation agents |
agonist (activating) |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Direct Interaction? | False |
agonist (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor; alpha4/beta2 agonist |
Direct Interaction | yes |
Trial Name | - |
agonist (activating) |
Details of the Assay for Interaction | <i>In vitro</i> affinity for recombinant human α4β2 receptors in membranes from transfected CHO-K1 cells, determined by displacement of [<sup>3</sup>H]-(−)-cytisine. |
Specific Action of the Ligand | Agonist |
Details of Interaction | α4β2 |
activator (activating) |
Details of the Assay for Interaction | Patch clamp |
Specific Action of the Ligand | Activation |
Details of Interaction | non-covalent |
54-11-5 | CAS Number |
American Fare Nicotine Transdermal System | Drug Brand |
Basic Care Nicotine | Drug Brand |
Drug Type | small molecule |
Drug Groups | approved |
Drug Categories | agents producing tachycardia |
Drug Class | central nervous system stimulants |
Year of Approval | 1996 |
Drug Indications | Central Nervous System Stimulants |
Drug Class | small molecule |
FDA Approval | 1996 |
C691 | NCI drug code |
CHEMBL3 | ChEMBL Drug ID |
D0T8GD | TTD Drug ID |