DGIdb - NIFEDIPINE Drug Record

NIFEDIPINE chembl:CHEMBL193 Approved

Alternate Names:

ADALAT RET
CALCHAN MR 10
HYPOLAR RET 10
NIFE-WOLFF
UNIPINE XL
ADALAT IC
CALCHAN MR 20
SLOFEDIPINE XL 30
ADIPINE XL
GENALAT 20 RET
ADALAT LA 20
ANGIOPINE 10
NIFEDOTARD 20 MR
CORODAY MR
GENALAT 10 RET
NIMODREL MR 10
BAY-A-1040
CORACTEN SR
ANGIOPINE MR 20
AFEDITAB CR
VASAD
CORACTEN XL
TENSIPINE MR 10
ADALAT
NIFELEASE
KENTIPINE MR 20
ANGIOPINE 5
HYPOLAR XL 30
KENTIPINE MR 10
ANGIOPINE MR 10
ADIPINE MR 20
HYPOLAR RET 20
NEOZIPINE XL
NIFEDIPRESS MR 20
CALANIF
FORTIPINE LA40
CARDILATE MR
NIVATEN RET
ADALAT A.R.
NIFEDIPINE
ADALAT LA 60
KENTIPINE
NIFOPRESS MR
NIMODREL XL
CALCILAT
VALNI XL
TENSIPINE MR 20
ADALAT CC
PROCARDIA
SLOFEDIPINE XL 60
ADANIF XL
ADALATE LP
PROCARDIA XL
NIMODREL MR 20
ADIPINE MR 10
VALNI 20 RET
NIFOPRESS RET
ADALAT LA 30
NIFEDIPRESS MR 10
NIFENSAR XL
ANGIOPINE 40 LA
ADIPINE
ADALAT®
NIFEDIPINO
NIFECOR
NIFEDIPRES
4-(2'-NITROPHENYL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDIN-3,5-DICARBONSAEUREDIMETHYLESTER
NIFECARD
ADAPINE
PROCARDIA®
NIFEDIPINUM
pubchem.compound:4485
drugbank:01115
chembl:CHEMBL193
chemidplus:21829-25-4
rxcui:7417

Drug Info:

Drug Class	vasodilator agents
Year of Approval	1981
Drug Class	antianginal agents
FDA Approval	1981
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Antianginal Agents

(4 More Sources)

Publications:

Karlsson et al., 1999, Cytosolic Ca2+ oscillations by gastrin releasing peptide in single HIT-T15 cells., Peptides
Boutillier et al., 1999, Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway., Eur. J. Neurosci.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Lee SJ et al., 2005, Recombinant CYP3A417 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A417 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype., J Pharmacol Exp Ther
Ohno et al., 2007, General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs., Clin Pharmacokinet
Hong X et al., 2007, Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS., Methods Find Exp Clin Pharmacol
Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
Krasowski MD et al., 2011, The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species., BMC Biochem
Robenek et al., Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. II. Characterization of intracellular morphologic changes., Arteriosclerosis
Schmitz et al., Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. I. Characterization of cellular lipid metabolism., Arteriosclerosis
Kim et al., 1999, Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein., Pharm. Res.
Morel et al., 1998, The action of calcium channel blockers on recombinant L-type calcium channel alpha1-subunits., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
Ozaki et al., 1998, Role of medullasin in nifedipine-induced gingival overgrowth in rats., Arch. Oral Biol.
Kunimatsu et al., 1996, Possible roles of medullasin in nifedipine-induced human gingival overgrowth., Arch. Oral Biol.
Oh et al., 1995, Acidic pH rapidly increases immunoreactivity of glial fibrillary acidic protein in cultured astrocytes., Glia
Wofchuk et al., 1995, Age-dependent changes in the regulation by external calcium ions of the phosphorylation of glial fibrillary acidic protein in slices of rat hippocampus., Brain Res. Dev. Brain Res.
Du et al., 1999, Calcium influx and activation of calpain I mediate acute reactive gliosis in injured spinal cord., Exp. Neurol.
Li et al., 2006, Ion channels in mesenchymal stem cells from rat bone marrow., Stem Cells
Bell et al., 2001, Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents., J. Neurophysiol.
Haas DM et al., 2013, Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic., Am J Perinatol
Sharp et al., 1994, Neuronal injury produced by NMDA antagonists can be detected using heat shock proteins and can be blocked with antipsychotics., Psychopharmacol Bull
Golba et al., 1995, The dihydropyridines modulate neurotensin inotropic action paradoxically., J. Physiol. Pharmacol.
Zhang Y et al., 2009, Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients., J Hum Genet
Wright et al., 2004, A role for calcium/calmodulin kinase in insulin stimulated glucose transport., Life Sci.
Higuchi et al., 1985, Effect of nifedipine treatment on cardiac myosin ATPase activity and responsiveness of cardiovascular system in the dog., Arch Int Pharmacodyn Ther

NIFEDIPINE SLC14A2

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17344938

Sources:
PharmGKB
NIFEDIPINE SOAT1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3341992 2829803

Sources:
NCI
NIFEDIPINE ELANE

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9796781 8833599

Sources:
NCI
NIFEDIPINE GRP

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10465509

Sources:
NCI
NIFEDIPINE NTS

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8770786

Sources:
NCI
NIFEDIPINE CACNA2D1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16484345 11752352

Sources:
TdgClinicalTrial TEND
NIFEDIPINE MYO9B

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3161480

Sources:
NCI
NIFEDIPINE GFAP

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7615340 7600665 10222112

Sources:
NCI
NIFEDIPINE CACNA1C

Interaction Score: 0.17

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
9846638 11752352 19029287

Sources:
ChemblInteractions
NIFEDIPINE CACNA1D

Interaction Score: 0.16

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
11160515 19029287

Sources:
ChemblInteractions
NIFEDIPINE APBA1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE CAMK2B

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14659970

Sources:
NCI
NIFEDIPINE CCND1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10051745

Sources:
NCI
NIFEDIPINE HSPA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7770620

Sources:
NCI
NIFEDIPINE CACNA1S

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
16675661

Sources:
ChemblInteractions
NIFEDIPINE CACNA1F

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions
NIFEDIPINE CACNA1B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19444285

Sources:
PharmGKB
NIFEDIPINE CYP3A5

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22875663

Sources:
PharmGKB
NIFEDIPINE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
21291553

Sources:
PharmGKB
NIFEDIPINE RORC

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE NFKB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE RGS4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE MPHOSPH8

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10213372

Sources:
NCI
NIFEDIPINE NR3C1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE HIF1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 15634941 17655375

Sources:
DTC NCI PharmGKB
NIFEDIPINE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NIFEDIPINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NIFEDIPINE HPGD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NIFEDIPINE KDM4E

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NIFEDIPINE ATAD5

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE BAZ2B

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE ALDH1A1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE MAPT

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE VDR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE GMNN

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: NIFEDIPINE
- Version: 01-August-2011
Alternate Names:

NIFEDIPINE Primary Drug Name

Drug Info:

Drug Class antianginal agents

Year of Approval 1981

Drug Class vasodilator agents

Publications:
TdgClinicalTrial: NIFEDIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antianginal Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:

NCI: NIFEDIPINE

Version: 14-September-2017

Alternate Names:

C29290 NCI drug code

Drug Info:

Publications:

Karlsson et al., 1999, Cytosolic Ca2+ oscillations by gastrin releasing peptide in single HIT-T15 cells., Peptides

Boutillier et al., 1999, Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway., Eur. J. Neurosci.

Kim et al., 1999, Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein., Pharm. Res.

DTC: NIFEDIPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL193 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: nifedipine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Hong X et al., 2007, Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS., Methods Find Exp Clin Pharmacol

Lee SJ et al., 2005, Recombinant CYP3A417 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A417 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype., J Pharmacol Exp Ther

Haas DM et al., 2013, Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic., Am J Perinatol

TTD: Nifedipine
- Version: 2020.06.01
Alternate Names:

D04OSE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL193
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL193
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Voltage-gated L-type calcium channel blocker

Novel drug target	Established target
Trial Name	-

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

NIFEDIPINE Drug Record

NIFEDIPINE chembl:CHEMBL193 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17344938

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3341992 2829803

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9796781 8833599

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10465509

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8770786

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16484345 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3161480

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7615340 7600665 10222112

Sources: NCI

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: 9846638 11752352 19029287

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 11160515 19029287

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14659970

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10051745

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7770620

Sources: NCI

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: 16675661

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19444285

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22875663

Interaction Types & Directionality:

n/a

PMIDs:
17344938

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
3341992 2829803

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9796781 8833599

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10465509

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8770786

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16484345 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
3161480

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7615340 7600665 10222112

Sources:
NCI

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
9846638 11752352 19029287

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
11160515 19029287

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
14659970

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10051745

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7770620

Sources:
NCI

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
16675661

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19444285

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22875663

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

PMIDs:
21291553

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10213372

Sources:
NCI