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NIFEDIPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • NIFEDIPINE chembl:CHEMBL193 Approved

    Alternate Names:

    ADALAT RET
    CALCHAN MR 10
    HYPOLAR RET 10
    NIFE-WOLFF
    UNIPINE XL
    ADALAT IC
    CALCHAN MR 20
    SLOFEDIPINE XL 30
    ADIPINE XL
    GENALAT 20 RET
    ADALAT LA 20
    ANGIOPINE 10
    NIFEDOTARD 20 MR
    CORODAY MR
    GENALAT 10 RET
    NIMODREL MR 10
    BAY-A-1040
    CORACTEN SR
    ANGIOPINE MR 20
    AFEDITAB CR
    VASAD
    CORACTEN XL
    TENSIPINE MR 10
    ADALAT
    NIFELEASE
    KENTIPINE MR 20
    ANGIOPINE 5
    HYPOLAR XL 30
    KENTIPINE MR 10
    ANGIOPINE MR 10
    ADIPINE MR 20
    HYPOLAR RET 20
    NEOZIPINE XL
    NIFEDIPRESS MR 20
    CALANIF
    FORTIPINE LA40
    CARDILATE MR
    NIVATEN RET
    ADALAT A.R.
    NIFEDIPINE
    ADALAT LA 60
    KENTIPINE
    NIFOPRESS MR
    NIMODREL XL
    CALCILAT
    VALNI XL
    TENSIPINE MR 20
    ADALAT CC
    PROCARDIA
    SLOFEDIPINE XL 60
    ADANIF XL
    ADALATE LP
    PROCARDIA XL
    NIMODREL MR 20
    ADIPINE MR 10
    VALNI 20 RET
    NIFOPRESS RET
    ADALAT LA 30
    NIFEDIPRESS MR 10
    NIFENSAR XL
    ANGIOPINE 40 LA
    ADIPINE
    ADALAT®
    NIFEDIPINO
    NIFECOR
    NIFEDIPRES
    4-(2'-NITROPHENYL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDIN-3,5-DICARBONSAEUREDIMETHYLESTER
    NIFECARD
    ADAPINE
    PROCARDIA®
    NIFEDIPINUM
    pubchem.compound:4485
    drugbank:01115
    chembl:CHEMBL193
    chemidplus:21829-25-4
    rxcui:7417

    Drug Info:

    Drug Class vasodilator agents
    Year of Approval 1981
    Drug Class antianginal agents
    FDA Approval 1981
    Drug Class small molecule
    Drug Indications Vasodilator Agents
    Drug Indications Antianginal Agents
    (4 More Sources)

    Publications:

    Karlsson et al., 1999, Cytosolic Ca2+ oscillations by gastrin releasing peptide in single HIT-T15 cells., Peptides
    Boutillier et al., 1999, Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway., Eur. J. Neurosci.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Lee SJ et al., 2005, Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype., J Pharmacol Exp Ther
    Ohno et al., 2007, General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs., Clin Pharmacokinet
    Hong X et al., 2007, Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS., Methods Find Exp Clin Pharmacol
    Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
    Krasowski MD et al., 2011, The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species., BMC Biochem
    Robenek et al., Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. II. Characterization of intracellular morphologic changes., Arteriosclerosis
    Schmitz et al., Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. I. Characterization of cellular lipid metabolism., Arteriosclerosis
    Kim et al., 1999, Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein., Pharm. Res.
    Morel et al., 1998, The action of calcium channel blockers on recombinant L-type calcium channel alpha1-subunits., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
    Ozaki et al., 1998, Role of medullasin in nifedipine-induced gingival overgrowth in rats., Arch. Oral Biol.
    Kunimatsu et al., 1996, Possible roles of medullasin in nifedipine-induced human gingival overgrowth., Arch. Oral Biol.
    Oh et al., 1995, Acidic pH rapidly increases immunoreactivity of glial fibrillary acidic protein in cultured astrocytes., Glia
    Wofchuk et al., 1995, Age-dependent changes in the regulation by external calcium ions of the phosphorylation of glial fibrillary acidic protein in slices of rat hippocampus., Brain Res. Dev. Brain Res.
    Du et al., 1999, Calcium influx and activation of calpain I mediate acute reactive gliosis in injured spinal cord., Exp. Neurol.
    Li et al., 2006, Ion channels in mesenchymal stem cells from rat bone marrow., Stem Cells
    Bell et al., 2001, Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents., J. Neurophysiol.
    Haas DM et al., 2013, Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic., Am J Perinatol
    Sharp et al., 1994, Neuronal injury produced by NMDA antagonists can be detected using heat shock proteins and can be blocked with antipsychotics., Psychopharmacol Bull
    Golba et al., 1995, The dihydropyridines modulate neurotensin inotropic action paradoxically., J. Physiol. Pharmacol.
    Zhang Y et al., 2009, Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients., J Hum Genet
    Wright et al., 2004, A role for calcium/calmodulin kinase in insulin stimulated glucose transport., Life Sci.
    Higuchi et al., 1985, Effect of nifedipine treatment on cardiac myosin ATPase activity and responsiveness of cardiovascular system in the dog., Arch Int Pharmacodyn Ther
  • NIFEDIPINE   SLC14A2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17344938


    Sources:
    PharmGKB

  • NIFEDIPINE   SOAT1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3341992 2829803


    Sources:
    NCI

  • NIFEDIPINE   ELANE

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9796781 8833599


    Sources:
    NCI

  • NIFEDIPINE   GRP

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10465509


    Sources:
    NCI

  • NIFEDIPINE   NTS

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8770786


    Sources:
    NCI

  • NIFEDIPINE   CACNA2D1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    16484345 11752352


    Sources:
    TdgClinicalTrial TEND

  • NIFEDIPINE   MYO9B

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3161480


    Sources:
    NCI

  • NIFEDIPINE   GFAP

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7615340 7600665 10222112


    Sources:
    NCI

  • NIFEDIPINE   CACNA1C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    9846638 11752352 19029287


    Sources:
    ChemblInteractions

  • NIFEDIPINE   CACNA1D

    Interaction Score: 0.16

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    11160515 19029287


    Sources:
    ChemblInteractions

  • NIFEDIPINE   APBA1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   CAMK2B

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14659970


    Sources:
    NCI

  • NIFEDIPINE   CCND1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10051745


    Sources:
    NCI

  • NIFEDIPINE   HSPA4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7770620


    Sources:
    NCI

  • NIFEDIPINE   CACNA1S

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    16675661


    Sources:
    ChemblInteractions

  • NIFEDIPINE   CACNA1F

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NIFEDIPINE   CACNA1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19444285


    Sources:
    PharmGKB

  • NIFEDIPINE   CYP3A5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22875663


    Sources:
    PharmGKB

  • NIFEDIPINE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    21291553


    Sources:
    PharmGKB

  • NIFEDIPINE   RORC

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   NFKB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   RGS4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   MPHOSPH8

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10213372


    Sources:
    NCI

  • NIFEDIPINE   NR3C1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   HIF1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300 15634941 17655375


    Sources:
    DTC NCI PharmGKB

  • NIFEDIPINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   CBX1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NIFEDIPINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NIFEDIPINE   HPGD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   ATXN2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NIFEDIPINE   KDM4E

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NIFEDIPINE   ATAD5

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   BAZ2B

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   ALDH1A1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   HSD17B10

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   MAPT

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   VDR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   GMNN

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: NIFEDIPINE

    • Version: 01-August-2011

    Alternate Names:
    NIFEDIPINE Primary Drug Name

    Drug Info:
    Drug Class antianginal agents
    Year of Approval 1981
    Drug Class vasodilator agents

    Publications:

  • TdgClinicalTrial: NIFEDIPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antianginal Agents
    Drug Indications Vasodilator Agents
    Drug Class small molecule

    Publications:

  • NCI: NIFEDIPINE

    • Version: 14-September-2017

    Alternate Names:
    C29290 NCI drug code

    Drug Info:

    Publications:
    Karlsson et al., 1999, Cytosolic Ca2+ oscillations by gastrin releasing peptide in single HIT-T15 cells., Peptides
    Boutillier et al., 1999, Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway., Eur. J. Neurosci.
    Kim et al., 1999, Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein., Pharm. Res.

  • DTC: NIFEDIPINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL193 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: nifedipine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Hong X et al., 2007, Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS., Methods Find Exp Clin Pharmacol
    Lee SJ et al., 2005, Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype., J Pharmacol Exp Ther
    Haas DM et al., 2013, Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic., Am J Perinatol

  • TTD: Nifedipine

    • Version: 2020.06.01

    Alternate Names:
    D04OSE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL193

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL193

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21