NINTEDANIB Drug Record
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NINTEDANIB chembl:CHEMBL502835 ApprovedAntineoplastic
Alternate Names:
VARGATEF BIBF1120 NINTEDANIB OFEV BIBF-1120 INTEDANIB METHYL (3Z)-3-[(4-{METHYL[(4-METHYLPIPERAZIN-1-YL)ACETYL]AMINO}ANILINO)(PHENYL)METHYLIDENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLATE OFEV® VARGATEF® BIBF 1120 drugbank:09079 chembl:CHEMBL502835 chemidplus:656247-17-5 rxcui:1592737 pubchem.compound:9809715 Drug Info:
Drug Class Kinase Inhibitors FDA Approval not approved Drug Class Small molecule Drug Indications antineoplastic agent Drug Categories antifibrotic agents Drug Categories cytochrome p-450 cyp3a substrates Drug Categories cytochrome p-450 cyp3a4 substrates Drug Categories cytochrome p-450 cyp3a4 substrates (strength unknown) Drug Categories cytochrome p-450 substrates Drug Categories heterocyclic compounds, fused-ring Drug Categories kinase inhibitor Drug Categories oct1 inhibitors Drug Categories oct1 substrates Drug Categories p-glycoprotein inhibitors Drug Categories p-glycoprotein substrates Drug Categories tyrosine kinase inhibitors Drug Categories ugt1a1 substrates Publications:
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Interaction Score: 0.47
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name BIBF-1120,Vargatef Novel drug target Established target Notes -
Interaction Score: 0.4
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Response Type resistant Indication/Tumor Type urinary bladder cancer Evidence Type Actionable -
Interaction Score: 0.37
Interaction Types & Directionality:
n/a Interaction Info:
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Interaction Score: 0.3
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 0.3
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 0.26
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes -
Interaction Score: 0.24
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes Trial Name BIBF-1120,Vargatef Novel drug target Established target -
Interaction Score: 0.23
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes Trial Name BIBF-1120,Vargatef Novel drug target Established target -
Interaction Score: 0.23
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Interaction Score: 0.23
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition -
Interaction Score: 0.17
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Novel drug target Established target Trial Name BIBF-1120,Vargatef Notes -
Interaction Score: 0.16
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.15
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Interaction Score: 0.11
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes -
Interaction Score: 0.11
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Interaction Score: 0.11
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Interaction Score: 0.08
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes -
Interaction Score: 0.07
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes -
Interaction Score: 0.07
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes -
Interaction Score: 0.07
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Interaction Score: 0.04
Interaction Types & Directionality:
n/a Interaction Info:
Drug family Pan-TK inhibitor Alteration RET__. -
Interaction Score: 0.01
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes
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Alternate Names:
NINTEDANIB DrugBank Drug Name 656247-17-5 CAS Number Ofev Drug Brand Drug Info:
Drug Type small molecule Drug Groups approved Drug Categories antifibrotic agents -
- Version: 20-Jun-2017
Alternate Names:
BIBF1120 Development Name NINTEDANIB Generic Name VARGATEF Trade Name Drug Info:
Drug Class Kinase Inhibitors Publications:
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- Version: January-2014
Alternate Names:
Drug Info:
Drug Indications antineoplastic agent Drug Class Small molecule FDA Approval not approved Publications:
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- Version: 02-September-2020
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CHEMBL502835 ChEMBL Drug ID Drug Info:
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- Version: 27-September-2017
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Drug Info:
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- Version: 12-May-2016
Alternate Names:
NINTEDANIB Primary Drug Name VARGATEF Drug Trade Name BIBF 1120 Drug Synonym Drug Info:
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Alternate Names:
D09HNV TTD Drug ID Drug Info:
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- Version: 29-September-2020
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NINTEDANIB GuideToPharmacology Ligand Name Drug Info:
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- Version: ChEMBL_27
Alternate Names:
Drug Info:
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- Version: 27-September-2017
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Drug Info:
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- Version: 15-June-2013
Alternate Names:
Drug Info:
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