DGIdb - NISOLDIPINE Drug Record

NISOLDIPINE chembl:CHEMBL1726 Approved

Alternate Names:

BAY-K-5552
SYSCOR MR 20
SULAR
NISOLDIPINE
SYSCOR MR 10
SYSCOR MR 30
NISOLDIPINUM
NISOLDIPINO
NISOLDIPIN
SULAR®
ISOBUTYL METHYL 2,6-DIMETHYL-4-(2-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
NISOLDIPINA
chembl:CHEMBL1726
rxcui:7435
drugbank:00401
chemidplus:63675-72-9
pubchem.compound:4499

Drug Info:

Drug Class	vasodilator agents
Drug Class	antihypertensive agents
Year of Approval	1995
FDA Approval	1995
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Antihypertensive Agents

(2 More Sources)

Publications:

Hu et al., 1998, Isoform-specific inhibition of L-type calcium channels by dihydropyridines is independent of isoform-specific gating properties., Mol. Pharmacol.
Morel et al., 1998, The action of calcium channel blockers on recombinant L-type calcium channel alpha1-subunits., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Wei et al., 1995, Molecular determinants of cardiac Ca2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding., J. Biol. Chem.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.

NISOLDIPINE CACNA1A

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
NISOLDIPINE CACNA1C

Interaction Score: 0.66

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
9584217 9846638 11752352 7592963

Sources:
ChemblInteractions
NISOLDIPINE CACNA1D

Interaction Score: 0.34

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
19029287

Sources:
ChemblInteractions
NISOLDIPINE CACNA1S

Interaction Score: 0.27

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
16675661

Sources:
ChemblInteractions
NISOLDIPINE CACNA1F

Interaction Score: 0.18

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NISOLDIPINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NISOLDIPINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NISOLDIPINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NISOLDIPINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NISOLDIPINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NISOLDIPINE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NISOLDIPINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NISOLDIPINE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NISOLDIPINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NISOLDIPINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: NISOLDIPINE
- Version: 01-August-2011
Alternate Names:

NISOLDIPINE Primary Drug Name

Drug Info:

Year of Approval 1995

Drug Class antihypertensive agents

Drug Class vasodilator agents

Publications:
TdgClinicalTrial: NISOLDIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:
DTC: NISOLDIPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1726 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Nisoldipine
- Version: 2020.06.01
Alternate Names:

D0S5CU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1726
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1726
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Voltage-gated L-type calcium channel blocker

Trial Name	-
Novel drug target	Established target

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

NISOLDIPINE Drug Record

NISOLDIPINE chembl:CHEMBL1726 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: 9584217 9846638 11752352 7592963

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 19029287

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 16675661

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: NISOLDIPINE

Alternate Names: NISOLDIPINE Primary Drug Name

Drug Info: Year of Approval 1995 Drug Class antihypertensive agents Drug Class vasodilator agents

Publications:

TdgClinicalTrial: NISOLDIPINE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Vasodilator Agents Drug Class small molecule

Publications:

DTC: NISOLDIPINE

Alternate Names: CHEMBL1726 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Nisoldipine

Alternate Names: D0S5CU TTD Drug ID

Drug Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
9584217 9846638 11752352 7592963

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
19029287

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
16675661

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

NISOLDIPINE Primary Drug Name

Drug Info:

Year of Approval 1995

Drug Class antihypertensive agents

Drug Class vasodilator agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Alternate Names:

CHEMBL1726 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0S5CU TTD Drug ID