DGIdb - NITROFURANTOIN Drug Record

NITROFURANTOIN chembl:CHEMBL572 Approved

Alternate Names:

MACRODANTIN
DANTAFUR
FURALAN
FURADANTIN
BERKFURIN
GENFURA
MACROBID
NITROFURANTOIN MACROCRYSTALLINE
NSC-2107
CEDURAN
IVADANTIN
NSC-44150
NITROFURANTOIN

Drug Info:

(2 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Wang et al., 2007, Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2., Drug Metab. Dispos.
Youngman et al., 1982, Mechanisms of oxygen activation by nitrofurantoin and relevance to its toxicity., Biochem. Pharmacol.
Pritchard JA et al., 1965, Severe anemia with hemolysis and megaloblastic erythropoiesis. A reaction to nitrofurantoin administered during pregnancy., JAMA
Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf
Syzdół P et al., 1991, [Recurrent acute renal failure during the course of hemolytic crisis in a patient with glucose-6-phosphate dehydrogenase deficiency]., Pol Tyg Lek
Lavelle KJ et al., 1976, Hyperlactatemia and hemolysis in G6PD deficiency after nitrofurantoin ingestion., Am J Med Sci

NITROFURANTOIN XDH

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6297496

Sources:
NCI
NITROFURANTOIN G6PD

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
5897424 20701405 1669155 12659

Sources:
PharmGKB FDA
NITROFURANTOIN ABCG2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17093006

Sources:
NCI
NITROFURANTOIN RORC

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NITROFURANTOIN USP1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NITROFURANTOIN CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NITROFURANTOIN CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NITROFURANTOIN CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NITROFURANTOIN CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NITROFURANTOIN CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NITROFURANTOIN NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: NITROFURANTOIN

Version: 14-September-2017

Alternate Names:

C29293 NCI drug code

Drug Info:

Publications:

Wang et al., 2007, Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2., Drug Metab. Dispos.

Youngman et al., 1982, Mechanisms of oxygen activation by nitrofurantoin and relevance to its toxicity., Biochem. Pharmacol.

DTC: NITROFURANTOIN
- Version: 02-September-2020
Alternate Names:

CHEMBL572 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: nitrofurantoin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Pritchard JA et al., 1965, Severe anemia with hemolysis and megaloblastic erythropoiesis. A reaction to nitrofurantoin administered during pregnancy., JAMA

Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf

Lavelle KJ et al., 1976, Hyperlactatemia and hemolysis in G6PD deficiency after nitrofurantoin ingestion., Am J Med Sci

TTD: Nitrofurantoin
- Version: 2020.06.01
Alternate Names:

D0R0BX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL572
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Nitrofurantoin
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

NITROFURANTOIN Drug Record

NITROFURANTOIN chembl:CHEMBL572 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6297496

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 5897424 20701405 1669155 12659

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17093006

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

NCI: NITROFURANTOIN

Alternate Names: C29293 NCI drug code

Drug Info:

Publications: Wang et al., 2007, Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2., Drug Metab. Dispos. Youngman et al., 1982, Mechanisms of oxygen activation by nitrofurantoin and relevance to its toxicity., Biochem. Pharmacol.

DTC: NITROFURANTOIN

Alternate Names: CHEMBL572 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: nitrofurantoin

Alternate Names:

Drug Info:

TTD: Nitrofurantoin

Alternate Names: D0R0BX TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL572

Alternate Names:

Drug Info:

Publications:

FDA: Nitrofurantoin

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
6297496

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
5897424 20701405 1669155 12659

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
17093006

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C29293 NCI drug code

Publications:

Wang et al., 2007, Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2., Drug Metab. Dispos.

Youngman et al., 1982, Mechanisms of oxygen activation by nitrofurantoin and relevance to its toxicity., Biochem. Pharmacol.

Alternate Names:

CHEMBL572 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0R0BX TTD Drug ID