• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

NITROFURANTOIN Drug Record

  • Summary
  • Interactions
  • Claims
  • NITROFURANTOIN chembl:CHEMBL572 Approved

    Alternate Names:

    MACRODANTIN
    DANTAFUR
    FURALAN
    FURADANTIN
    BERKFURIN
    GENFURA
    MACROBID
    NITROFURANTOIN MACROCRYSTALLINE
    NSC-2107
    CEDURAN
    IVADANTIN
    NSC-44150
    NITROFURANTOIN

    Drug Info:

    (2 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Wang et al., 2007, Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2., Drug Metab. Dispos.
    Youngman et al., 1982, Mechanisms of oxygen activation by nitrofurantoin and relevance to its toxicity., Biochem. Pharmacol.
    Pritchard JA et al., 1965, Severe anemia with hemolysis and megaloblastic erythropoiesis. A reaction to nitrofurantoin administered during pregnancy., JAMA
    Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf
    Syzdół P et al., 1991, [Recurrent acute renal failure during the course of hemolytic crisis in a patient with glucose-6-phosphate dehydrogenase deficiency]., Pol Tyg Lek
    Lavelle KJ et al., 1976, Hyperlactatemia and hemolysis in G6PD deficiency after nitrofurantoin ingestion., Am J Med Sci
  • NITROFURANTOIN   XDH

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6297496


    Sources:
    NCI

  • NITROFURANTOIN   G6PD

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    5897424 20701405 1669155 12659


    Sources:
    PharmGKB FDA

  • NITROFURANTOIN   ABCG2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17093006


    Sources:
    NCI

  • NITROFURANTOIN   RORC

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NITROFURANTOIN   USP1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NITROFURANTOIN   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NITROFURANTOIN   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NITROFURANTOIN   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NITROFURANTOIN   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NITROFURANTOIN   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NITROFURANTOIN   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: NITROFURANTOIN

    • Version: 14-September-2017

    Alternate Names:
    C29293 NCI drug code

    Drug Info:

    Publications:
    Wang et al., 2007, Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2., Drug Metab. Dispos.
    Youngman et al., 1982, Mechanisms of oxygen activation by nitrofurantoin and relevance to its toxicity., Biochem. Pharmacol.

  • DTC: NITROFURANTOIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL572 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: nitrofurantoin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Pritchard JA et al., 1965, Severe anemia with hemolysis and megaloblastic erythropoiesis. A reaction to nitrofurantoin administered during pregnancy., JAMA
    Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf
    Lavelle KJ et al., 1976, Hyperlactatemia and hemolysis in G6PD deficiency after nitrofurantoin ingestion., Am J Med Sci

  • TTD: Nitrofurantoin

    • Version: 2020.06.01

    Alternate Names:
    D0R0BX TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL572

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Nitrofurantoin

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21