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NORELGESTROMIN Drug Record

  • Summary
  • Interactions
  • Claims
  • NORELGESTROMIN chembl:CHEMBL1200807 Approved

    Alternate Names:

    ORTHO EVRA
    DEACETYLNORGESTIMATE
    EVRA
    RWJ-10553
    NORELGESTROMIN
    17-DEACYLNORGESTIMATE
    pubchem.compound:9568628
    rxcui:326374
    chemidplus:53016-31-2
    chembl:CHEMBL1200807
    drugbank:06713

    Drug Info:

    FDA Approval approved
    Drug Class Small molecule
    Drug Indications contraceptive
    (0 More Sources)

    Publications:

    London et al., 1992, Comparative contraceptive efficacy and mechanism of action of the norgestimate-containing triphasic oral contraceptive., Acta Obstet Gynecol Scand Suppl
    Kuhnz et al., 1995, Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor., Contraception
    Pasqualini, 2009, Breast cancer and steroid metabolizing enzymes: the role of progestogens., Maturitas
    Juchem et al., 1993, Receptor binding of norgestimate--a new orally active synthetic progestational compound., Contraception
    Graziottin, 2006, A review of transdermal hormonal contraception : focus on the ethinylestradiol/norelgestromin contraceptive patch., Treat Endocrinol
    Prifti S et al., 2004, Induction of androgen receptor activity by norgestimate and norelgestromin in MDA-MB 231 breast cancer cells., Gynecol Endocrinol
  • NORELGESTROMIN   PGR

    Interaction Score: 2.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name norelgestromin/ethinyl estradiol,Ortho Evra
    Novel drug target Established target
    Mechanism of Interaction Progesterone receptor agonist

    PMIDs:
    1324557 7750291 19962254 8384965 17107221


    Sources:
    TdgClinicalTrial ChemblInteractions

  • NORELGESTROMIN   ESR1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name norelgestromin/ethinyl estradiol,Ortho Evra
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • NORELGESTROMIN   AR

    Interaction Score: 0.05

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    15625768


    Sources:
    DTC

  • TdgClinicalTrial: NORELGESTROMIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications contraceptive
    Drug Class Small molecule
    FDA Approval approved

    Publications:

  • DTC: NORELGESTROMIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1200807 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1200807

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1200807

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21