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NOREPINEPHRINE Drug Record

  • Summary
  • Interactions
  • Claims
  • NOREPINEPHRINE chembl:CHEMBL1437 Approved

    Alternate Names:

    R-NOREPINEPHRINE
    NOREPINEPHRINE
    LEVOPHED
    (R)-NOREPINEPHRINE
    LEVARTERENOL®
    (R)-4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL
    AKTAMIN
    (-)-ARTERENOL
    NORADRENALINE
    (R)-NORADRENALINE
    4-[(1R)-2-AMINO-1-HYDROXYETHYL]BENZENE-1,2-DIOL
    LEVONOREPINEPHRINE
    LEVOARTERENOL
    (-)-NORADRENALINE
    LEVONORADRENALINE
    NOREPIRENAMINE
    4-[(1R)-2-AMINO-1-HYDROXY-ETHYL]BENZENE-1,2-DIOL
    (-)-NOREPINEPHRINE
    NORARTRINAL
    L-ARTERENOL
    L-3,4-DIHYDROXYPHENYLETHANOLAMINE
    4-[(1R)-2-AMINO-1-HYDROXYETHYL]-1,2-BENZENEDIOL
    NORADRENALIN
    L-2-AMINO-1-(3,4-DIHYDROXYPHENYL)ETHANOL
    (R)-(-)-NOREPINEPHRINE
    NOREPINEFRINA
    NOREPINEPHRINUM
    NOR-ADRENALINE
    L-NORADRENALINE
    (-)-ALPHA-(AMINOMETHYL)PROTOCATECHUYL ALCOHOL
    LEVONOR
    4-[(1R)-2-AMINO-1-HYDROXY-ETHYL]PYROCATECHOL
    LEVARTERENOL
    4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL
    L-ALPHA-(AMINOMETHYL)-3,4-DIHYDROXYBENZYL ALCOHOL
    ARTERENOL
    NOR-EPIRENAN
    ADRENOR
    (-)-(R)-NOREPINEPHRINE
    SYMPATHIN E
    L-NOREPINEPHRINE
    chembl:CHEMBL1437
    pubchem.compound:439260
    rxcui:7512
    drugbank:00368
    chemidplus:51-41-2

    Drug Info:

    Year of Approval 1950
    Drug Class vasoconstrictor agents
    Drug Class antihypotensive agents
    FDA Approval 1950
    Drug Class small molecule
    Drug Indications Vasoconstrictor Agents
    Drug Indications Antihypotensive Agents
    (2 More Sources)

    Publications:

    Rump et al., 1995, Alpha 2C-adrenoceptor-modulated release of noradrenaline in human right atrium., Br. J. Pharmacol.
    Nash, 1990, Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism., Clin Cardiol
    Bruck et al., 2007, Presynaptic alpha-2C adrenoceptor-mediated control of noradrenaline release in humans: genotype- or age-dependent?, Clin. Pharmacol. Ther.
    Shreve et al., 1991, Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine., Eur. J. Pharmacol.
    Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Vizi et al., 2001, Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung., Eur. J. Pharmacol.
    Gobbi et al., 1990, The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype., Naunyn Schmiedebergs Arch. Pharmacol.
    Rudling et al., 2000, A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes., Br. J. Pharmacol.
    Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
    Lachnit et al., 1997, Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat., Br. J. Pharmacol.
    Burt et al., 1996, The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens., Br. J. Pharmacol.
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
    Hieble et al., 1998, Molecular basis for the stereoselective interactions of catecholamines with alpha-adrenoceptors., Proc. West. Pharmacol. Soc.
    Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
    Nyrönen et al., 2001, Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine., Mol. Pharmacol.
    MacLennan et al., 2000, Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes., Br. J. Pharmacol.
    Cleary et al., 2004, Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens., Br. J. Pharmacol.
    Kenny et al., 1995, Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline., Br. J. Pharmacol.
    Testa et al., 1995, The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta., Life Sci.
    Testa et al., 1995, Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype., Br. J. Pharmacol.
    Izzo et al., 1994, Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells., J. Biol. Chem.
    Izzo et al., 1994, Regulation of alpha 1B-adrenergic receptor half-life: protein synthesis dependence and effect of norepinephrine., Am. J. Physiol.
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    El-Armouche et al., 2009, Beta-adrenergic stimulation and myocardial function in the failing heart., Heart Fail Rev
    Mersmann, 1998, Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action., J. Anim. Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Molenaar P et al., 2002, Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro., J Am Coll Cardiol
    Tarizzo et al., 1994, Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat., Naunyn Schmiedebergs Arch. Pharmacol.
    Weinshenker et al., 2001, Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine., J. Pharmacol. Exp. Ther.
    Sanders, 1998, The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function., Adv. Exp. Med. Biol.
  • NOREPINEPHRINE   ADRA1D

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    15451776 7582530 18064417 17266602 7674815 17016423 17139284


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • NOREPINEPHRINE   ADRA2B

    Interaction Score: 0.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1980236 11728431 1979424 11053214 18064417 17016423 17139284


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • NOREPINEPHRINE   ADRA2A

    Interaction Score: 0.49

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16407989 1980236 9836297 18680204 11306720 10742288 18064417 17016423 17139284


    Sources:
    DTC TdgClinicalTrial TEND PharmGKB

  • NOREPINEPHRINE   ADRA1B

    Interaction Score: 0.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7773533 8294418 8166240 18064417 17266602 17016423 17139284


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • NOREPINEPHRINE   ADRA2C

    Interaction Score: 0.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8590979 1980236 17410123 1654268 18064417 17016423 17139284


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • NOREPINEPHRINE   ADRB1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    2903243 19110970 9464897 18064417 11752352 12383575


    Sources:
    DTC PharmGKB TTD

  • NOREPINEPHRINE   ADRA1A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17266602 9138687 8825367 17016423 17139284


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • NOREPINEPHRINE   MBNL1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   ADRB2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    2903243 9464897 7969507 11504801 19110970 18064417 9666280 17016423 17139284


    Sources:
    DTC

  • NOREPINEPHRINE   COMT

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NOREPINEPHRINE   TDP1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   BLM

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   POLH

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   RECQL

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   APEX1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   FEN1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   POLI

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   POLK

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   MAPT

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   KDM4A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOREPINEPHRINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: NOREPINEPHRINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class antihypotensive agents
    Drug Class vasoconstrictor agents
    Year of Approval 1950

    Publications:

  • TdgClinicalTrial: NOREPINEPHRINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypotensive Agents
    Drug Indications Vasoconstrictor Agents
    Drug Class small molecule

    Publications:

  • DTC: NOREPINEPHRINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1437 ChEMBL Drug ID

    Drug Info:

    Publications:
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

  • PharmGKB: norepinephrine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Molenaar P et al., 2002, Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro., J Am Coll Cardiol

  • TTD: Norepinephrine

    • Version: 2020.06.01

    Alternate Names:
    D07MOX TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1437

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21