DGIdb - NOREPINEPHRINE Drug Record

NOREPINEPHRINE chembl:CHEMBL1437 Approved

Alternate Names:

R-NOREPINEPHRINE
NOREPINEPHRINE
LEVOPHED
(R)-NOREPINEPHRINE
LEVARTERENOL®
(R)-4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL
AKTAMIN
(-)-ARTERENOL
NORADRENALINE
(R)-NORADRENALINE
4-[(1R)-2-AMINO-1-HYDROXYETHYL]BENZENE-1,2-DIOL
LEVONOREPINEPHRINE
LEVOARTERENOL
(-)-NORADRENALINE
LEVONORADRENALINE
NOREPIRENAMINE
4-[(1R)-2-AMINO-1-HYDROXY-ETHYL]BENZENE-1,2-DIOL
(-)-NOREPINEPHRINE
NORARTRINAL
L-ARTERENOL
L-3,4-DIHYDROXYPHENYLETHANOLAMINE
4-[(1R)-2-AMINO-1-HYDROXYETHYL]-1,2-BENZENEDIOL
NORADRENALIN
L-2-AMINO-1-(3,4-DIHYDROXYPHENYL)ETHANOL
(R)-(-)-NOREPINEPHRINE
NOREPINEFRINA
NOREPINEPHRINUM
NOR-ADRENALINE
L-NORADRENALINE
(-)-ALPHA-(AMINOMETHYL)PROTOCATECHUYL ALCOHOL
LEVONOR
4-[(1R)-2-AMINO-1-HYDROXY-ETHYL]PYROCATECHOL
LEVARTERENOL
4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL
L-ALPHA-(AMINOMETHYL)-3,4-DIHYDROXYBENZYL ALCOHOL
ARTERENOL
NOR-EPIRENAN
ADRENOR
(-)-(R)-NOREPINEPHRINE
SYMPATHIN E
L-NOREPINEPHRINE
chembl:CHEMBL1437
pubchem.compound:439260
rxcui:7512
drugbank:00368
chemidplus:51-41-2

Drug Info:

Year of Approval	1950
Drug Class	vasoconstrictor agents
Drug Class	antihypotensive agents
FDA Approval	1950
Drug Class	small molecule
Drug Indications	Vasoconstrictor Agents
Drug Indications	Antihypotensive Agents

(2 More Sources)

Publications:

Rump et al., 1995, Alpha 2C-adrenoceptor-modulated release of noradrenaline in human right atrium., Br. J. Pharmacol.
Nash, 1990, Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism., Clin Cardiol
Bruck et al., 2007, Presynaptic alpha-2C adrenoceptor-mediated control of noradrenaline release in humans: genotype- or age-dependent?, Clin. Pharmacol. Ther.
Shreve et al., 1991, Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine., Eur. J. Pharmacol.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Vizi et al., 2001, Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung., Eur. J. Pharmacol.
Gobbi et al., 1990, The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype., Naunyn Schmiedebergs Arch. Pharmacol.
Rudling et al., 2000, A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes., Br. J. Pharmacol.
Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
Lachnit et al., 1997, Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat., Br. J. Pharmacol.
Burt et al., 1996, The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens., Br. J. Pharmacol.
Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
Hieble et al., 1998, Molecular basis for the stereoselective interactions of catecholamines with alpha-adrenoceptors., Proc. West. Pharmacol. Soc.
Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
Nyrönen et al., 2001, Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine., Mol. Pharmacol.
MacLennan et al., 2000, Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes., Br. J. Pharmacol.
Cleary et al., 2004, Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens., Br. J. Pharmacol.
Kenny et al., 1995, Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline., Br. J. Pharmacol.
Testa et al., 1995, The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta., Life Sci.
Testa et al., 1995, Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype., Br. J. Pharmacol.
Izzo et al., 1994, Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells., J. Biol. Chem.
Izzo et al., 1994, Regulation of alpha 1B-adrenergic receptor half-life: protein synthesis dependence and effect of norepinephrine., Am. J. Physiol.
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
El-Armouche et al., 2009, Beta-adrenergic stimulation and myocardial function in the failing heart., Heart Fail Rev
Mersmann, 1998, Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action., J. Anim. Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Molenaar P et al., 2002, Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro., J Am Coll Cardiol
Tarizzo et al., 1994, Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat., Naunyn Schmiedebergs Arch. Pharmacol.
Weinshenker et al., 2001, Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine., J. Pharmacol. Exp. Ther.
Sanders, 1998, The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function., Adv. Exp. Med. Biol.

NOREPINEPHRINE ADRA1D

Interaction Score: 1.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
NOREPINEPHRINE ADRA2B

Interaction Score: 0.55

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1980236 11728431 1979424 11053214 18064417 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
NOREPINEPHRINE ADRA2A

Interaction Score: 0.49

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16407989 1980236 9836297 18680204 11306720 10742288 18064417 17016423 17139284

Sources:
DTC TdgClinicalTrial TEND PharmGKB
NOREPINEPHRINE ADRA1B

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7773533 8294418 8166240 18064417 17266602 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
NOREPINEPHRINE ADRA2C

Interaction Score: 0.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8590979 1980236 17410123 1654268 18064417 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
NOREPINEPHRINE ADRB1

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
2903243 19110970 9464897 18064417 11752352 12383575

Sources:
DTC PharmGKB TTD
NOREPINEPHRINE ADRA1A

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17266602 9138687 8825367 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
NOREPINEPHRINE MBNL1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE ADRB2

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
2903243 9464897 7969507 11504801 19110970 18064417 9666280 17016423 17139284

Sources:
DTC
NOREPINEPHRINE COMT

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NOREPINEPHRINE TDP1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE BLM

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE POLH

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE RECQL

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE APEX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE FEN1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE POLI

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE POLK

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE KDM4A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOREPINEPHRINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: NOREPINEPHRINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class antihypotensive agents

Drug Class vasoconstrictor agents

Year of Approval 1950

Publications:
TdgClinicalTrial: NOREPINEPHRINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypotensive Agents

Drug Indications Vasoconstrictor Agents

Drug Class small molecule

Publications:

DTC: NOREPINEPHRINE

Version: 02-September-2020

Alternate Names:

CHEMBL1437 ChEMBL Drug ID

Drug Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

PharmGKB: norepinephrine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Molenaar P et al., 2002, Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro., J Am Coll Cardiol

TTD: Norepinephrine
- Version: 2020.06.01
Alternate Names:

D07MOX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1437
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

NOREPINEPHRINE Drug Record

NOREPINEPHRINE chembl:CHEMBL1437 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1980236 11728431 1979424 11053214 18064417 17016423 17139284

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16407989 1980236 9836297 18680204 11306720 10742288 18064417 17016423 17139284

Sources: DTC TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7773533 8294418 8166240 18064417 17266602 17016423 17139284

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8590979 1980236 17410123 1654268 18064417 17016423 17139284

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 2903243 19110970 9464897 18064417 11752352 12383575

Sources: DTC PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17266602 9138687 8825367 17016423 17139284

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 2903243 9464897 7969507 11504801 19110970 18064417 9666280 17016423 17139284

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1980236 11728431 1979424 11053214 18064417 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16407989 1980236 9836297 18680204 11306720 10742288 18064417 17016423 17139284

Sources:
DTC TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7773533 8294418 8166240 18064417 17266602 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8590979 1980236 17410123 1654268 18064417 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

PMIDs:
2903243 19110970 9464897 18064417 11752352 12383575

Sources:
DTC PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17266602 9138687 8825367 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
2903243 9464897 7969507 11504801 19110970 18064417 9666280 17016423 17139284

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Class antihypotensive agents

Drug Class vasoconstrictor agents

Year of Approval 1950

Drug Info:

Drug Indications Antihypotensive Agents

Drug Indications Vasoconstrictor Agents

Drug Class small molecule

Alternate Names:

CHEMBL1437 ChEMBL Drug ID

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

Publications:

Molenaar P et al., 2002, Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro., J Am Coll Cardiol