DGIdb - NORETHINDRONE Drug Record

NORETHINDRONE chembl:CHEMBL1162 Approved

Alternate Names:

CAMILA
FEMHRT
NSC-9564
NORLUTIN
MICRONOR HRT
NORLUTATE
NORETHINDRONE
MICRONOR
AYGESTIN
INCASSIA
ACTIVELLA
MENZOL
NORETHISTERONE
NOR-QD
PRIMOLUT N
NORIDAY
ERRIN
SC-4640
HEATHER
UTOVLAN
JENCYCLA
NORETHIDRONE
COMBIPATCH
4-ESTREN-17ALPHA-ETHYNYL-17BETA-OL-3-ONE
17ALPHA-ETHINYL-19-NORTESTOSTERONE
NORETHISTERON
19-NOR-17ALPHA-ETHYNYLANDROSTEN-17BETA-OL-3-ONE
19-NOR-17-ALPHA-ETHYNYL-17-BETA-HYDROXY-4-ANDROSTEN-3-ONE
17ALPHA-ETHYNYL-19-NORTESTOSTERONE
NORETISTERONA
(17ALPHA)-17-ETHYNYL-17-HYDROXYESTRA-4,8(14),9-TRIEN-3-ONE
19-NOR-17ALPHA-ETHYNYL-17BETA-HYDROXY-4-ANDROSTEN-3-ONE
NORIDAY®
NEA713
17Α-ETHINYL-19-NORTESTOSTERONE
19-NORETHISTERONE
17ALPHA-ETHYNYL-19-NOR-4-ANDROSTEN-17BETA-OL-3-ONE
19-NOR-17-ALPHA-ETHYNYLTESTOSTERONE
19-NOR-17ALPHA-ETHYNYLTESTOSTERONE
17ALPHA-ETHYNYL-19-NORANDROST-4-EN-17BETA-OL-3-ONE
17-ALPHA-ETHYNYL-19-NORANDROST-4-EN-17-BETA-OL-3-ONE
PRIMOLUT-N
NORETHISTERONUM
19-NOR-17-ALPHA-ETHYNYLANDROSTEN-17-BETA-OL-3-ONE
17-ALPHA-ETHYNYL-4-ESTREN-17-OL-3-ONE
17ALPHA-ETHINYLESTRA-4-EN-17BETA-OL-3-ONE
17ALPHA-ETHYNYL-4-ESTREN-17-OL-3-ONE
19-NOR-ETHINDRONE
17-HYDROXY-19-NOR-17ALPHA-PREGN-4-EN-20-YN-3-ONE
17ALPHA-ETHYNYL-17BETA-HYDROXY-19-NORANDROST-4-EN-3-ONE
17ALPHA-ETHYNYL-17-HYDROXY-4-ESTREN-3-ONE
17-ALPHA-ETHYNYL-17-HYDROXY-4-ESTREN-3-ONE
17-ALPHA-ETHYNYL-19-NORTESTOSTERONE
17BETA-HYDROXY-19-NORPREGN-4-EN-20-YN-3-ONE
MICRONOR®
19-NOR-17Α-ETHYNYLTESTOSTERONE
17-BETA-HYDROXY-19-NORPREGN-4-EN-20-YN-3-ONE
17-HYDROXY-19-NOR-17-ALPHA-PREGN-4-EN-20-YN-3-ONE
chemidplus:68-22-4
rxcui:7514
drugbank:00717
pubchem.compound:6230
chembl:CHEMBL1162

Drug Info:

Year of Approval	approved before 1982
Drug Class	contraceptives, oral, synthetic
FDA Approval	Approved before 1982
Drug Indications	Contraceptives, Oral, Synthetic
FDA Approval	approved
Drug Class	small molecule
Drug Indications	contraceptive

(6 More Sources)

Publications:

Gal et al., 1981, Failure of contraceptive steroids to modify human chorionic gonadotrophin secretion by hydatidiform mole tissue and choriocarcinoma cells in culture., Steroids
Gräf et al., 1978, The role of the anterior pituitary gland in progestagen-induced proliferative mammary gland changes in the beagle., Arzneimittelforschung
Sitruk-Ware, 2004, Pharmacological profile of progestins., Maturitas
Madauss et al., 2004, Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes., J. Med. Chem.
Mirkin et al., 2005, Effect of 17 beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells., Fertil. Steril.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Mendoza-Rodríguez et al., 1999, Variations of progesterone receptor and c-fos gene expression in the rat uterus after treatment with norethisterone and its A-ring reduced metabolites., Contraception
García-Becerra et al., 2004, Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins., J. Steroid Biochem. Mol. Biol.
Pasapera et al., 1995, Norethisterone metabolites modulate the uteroglobin and progesterone receptor gene expression in prepubertal rabbits., Biol. Reprod.
Ottosson et al., 1981, Effects of sex hormone binding globulin capacity and pregnancy zone protein of treatment with combinations of ethinyl-oestradiol and norethisterone., Maturitas
Rugarn et al., 2001, Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum., Regul. Pept.
Notelovitz et al., 1992, Changes in coagulation and anticoagulation in women taking low-dose triphasic oral contraceptives: a controlled comparative 12-month clinical trial., Am. J. Obstet. Gynecol.

NORETHINDRONE CGB5

Interaction Score: 4.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7027540

Sources:
NCI
NORETHINDRONE PZP

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7199610

Sources:
NCI
NORETHINDRONE NTS

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11495683

Sources:
NCI
NORETHINDRONE PGR

Interaction Score: 1.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Warner

Novel drug target Established target

Trial Name -

PMIDs:
15189034 16084894 11752352 10494488 15261304 7711211 15063480

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
NORETHINDRONE PLG

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1442974

Sources:
NCI
NORETHINDRONE PRL

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
580200

Sources:
NCI
NORETHINDRONE AR

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
15063480

Sources:
DTC
NORETHINDRONE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NORETHINDRONE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: NORETHINDRONE
- Version: 01-August-2011
Alternate Names:

NORETHINDRONE Primary Drug Name

Drug Info:

Drug Class contraceptives, oral, synthetic

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: NORETHINDRONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications contraceptive

Drug Class small molecule

FDA Approval approved

Publications:
TdgClinicalTrial: NORETHISTERONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications contraceptive

Drug Class small molecule

FDA Approval approved

Publications:

NCI: NORETHINDRONE

Version: 14-September-2017

Alternate Names:

C702 NCI drug code

Drug Info:

Publications:

Notelovitz et al., 1992, Changes in coagulation and anticoagulation in women taking low-dose triphasic oral contraceptives: a controlled comparative 12-month clinical trial., Am. J. Obstet. Gynecol.

Gal et al., 1981, Failure of contraceptive steroids to modify human chorionic gonadotrophin secretion by hydatidiform mole tissue and choriocarcinoma cells in culture., Steroids

NCI: NORETHISTERONE

Version: 14-September-2017

Alternate Names:

C702 NCI drug code

Drug Info:

Publications:

Gräf et al., 1978, The role of the anterior pituitary gland in progestagen-induced proliferative mammary gland changes in the beagle., Arzneimittelforschung

Rugarn et al., 2001, Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum., Regul. Pept.

Ottosson et al., 1981, Effects of sex hormone binding globulin capacity and pregnancy zone protein of treatment with combinations of ethinyl-oestradiol and norethisterone., Maturitas

TTD: Norethindrone
- Version: 2020.06.01
Alternate Names:

D0GL7U TTD Drug ID

Drug Info:

Publications:
DTC: NORETHINDRONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1162 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1162
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: norethindrone
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1162
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	Warner
Novel drug target	Established target
Trial Name	-

NORETHINDRONE Drug Record

NORETHINDRONE chembl:CHEMBL1162 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7027540

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7199610

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11495683

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Warner Novel drug target Established target Trial Name -

PMIDs: 15189034 16084894 11752352 10494488 15261304 7711211 15063480

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1442974

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 580200

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 15063480

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: NORETHINDRONE

Alternate Names: NORETHINDRONE Primary Drug Name

Drug Info: Drug Class contraceptives, oral, synthetic Year of Approval approved before 1982

Publications:

TdgClinicalTrial: NORETHINDRONE

Alternate Names:

Drug Info: Drug Indications contraceptive Drug Class small molecule FDA Approval approved

Publications:

TdgClinicalTrial: NORETHISTERONE

Alternate Names:

Drug Info: Drug Indications contraceptive Drug Class small molecule FDA Approval approved

Publications:

NCI: NORETHINDRONE

Alternate Names: C702 NCI drug code

Drug Info:

NCI: NORETHISTERONE

Alternate Names: C702 NCI drug code

Drug Info:

TTD: Norethindrone

Alternate Names: D0GL7U TTD Drug ID

Drug Info:

Publications:

DTC: NORETHINDRONE

Alternate Names: CHEMBL1162 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1162

Alternate Names:

Drug Info:

Publications:

PharmGKB: norethindrone

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1162

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
7027540

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7199610

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11495683

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Warner

Novel drug target Established target

Trial Name -

PMIDs:
15189034 16084894 11752352 10494488 15261304 7711211 15063480

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
1442974

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
580200

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

PMIDs:
15063480

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

NORETHINDRONE Primary Drug Name

Drug Info:

Drug Class contraceptives, oral, synthetic

Year of Approval approved before 1982

Drug Info:

Drug Indications contraceptive

Drug Class small molecule

FDA Approval approved

Drug Info:

Drug Indications contraceptive

Drug Class small molecule

FDA Approval approved

Alternate Names:

C702 NCI drug code

Alternate Names:

C702 NCI drug code

Alternate Names:

D0GL7U TTD Drug ID

Alternate Names:

CHEMBL1162 ChEMBL Drug ID