DGIdb - NORTRIPTYLINE Drug Record

NORTRIPTYLINE chembl:CHEMBL445 Approved

Alternate Names:

MOTIPRESS
MOTIVAL
NCI-169453
AVENTYL
PAMELOR
ALLEGRON
NORTRIPTYLINE
NORITREN
10,11-DIHYDRO-N-METHYL-5H-DIBENZO[A,D]CYCLOHEPTENE-DELTA(5,GAMMA)-PROPYLAMINE
PSYCHOSTYL
DESMETHYLAMITRIPTYLINE
PAMELOR®
SENSAVAL
3-(10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDENE)-N-METHYL-1-PROPANAMINE
DEMETHYLAMITRIPTYLINE
ATEBEN
AVENTYL®
AVANTYL
NORTRIPTYLINE HYDROCHLORIDE
pubchem.compound:4543
chembl:CHEMBL445
chemidplus:72-69-5
drugbank:00540
rxcui:7531

Drug Info:

Year of Approval	approved before 1982
Drug Class	antidepressive agents, tricyclic
Drug Indications	antidepressant
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiasthmatic agent

(3 More Sources)

Publications:

Roberts RL et al., 2002, A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression., Pharmacogenomics J
Barker et al., 1996, Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter., Mol. Pharmacol.
Roubert et al., 2001, A Na(+)/Cl(-)-dependent transporter for catecholamines, identified as a norepinephrine transporter, is expressed in the brain of the teleost fish medaka (Oryzias latipes)., Mol. Pharmacol.
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Roubert et al., 2001, Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity., J. Biol. Chem.
Vaishnavi et al., 2004, Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity., Biol. Psychiatry
Kim et al., 2006, Monoamine transporter gene polymorphisms and antidepressant response in koreans with late-life depression., JAMA
Rausch et al., 2003, Initial platelet serotonin (5-HT) transport kinetics predict nortriptyline treatment outcome., J Clin Psychopharmacol
Joyce et al., 2003, Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline., Int. J. Neuropsychopharmacol.
Wisner et al., 2006, Postpartum depression: a randomized trial of sertraline versus nortriptyline., J Clin Psychopharmacol
Pollock et al., 2000, Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression., Neuropsychopharmacology
Keers R et al., 2011, Variation in GNB3 predicts response and adverse reactions to antidepressants., J Psychopharmacol
Perroud N et al., 2009, Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project., Neuropsychopharmacology
Lin E et al., 2015, Genome-wide association studies in pharmacogenomics of antidepressants., Pharmacogenomics
Uher R et al., 2010, Genome-wide pharmacogenetics of antidepressant response in the GENDEP project., Am J Psychiatry
Malki K et al., 2011, Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants., Biol Psychiatry

NORTRIPTYLINE UST

Interaction Score: 16.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25916525 20360315

Sources:
PharmGKB
NORTRIPTYLINE SLC39A14

Interaction Score: 11.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20970119

Sources:
PharmGKB
NORTRIPTYLINE SLC6A2

Interaction Score: 1.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-170

Novel drug target Established target

Trial Name CRx-191

PMIDs:
8863842 11502876 9537821 11092898 14744476 17018806

Sources:
TdgClinicalTrial TEND
NORTRIPTYLINE GNB3

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20826553

Sources:
PharmGKB
NORTRIPTYLINE SLC6A4

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-191

Novel drug target Established target

Trial Name CRx-170

PMIDs:
12640215 9537821 14744476 14604448 16855451 11027924

Sources:
TdgClinicalTrial TEND
NORTRIPTYLINE BDNF

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19641488

Sources:
PharmGKB
NORTRIPTYLINE ABCB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12082591

Sources:
PharmGKB
NORTRIPTYLINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NORTRIPTYLINE ATXN2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NORTRIPTYLINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC FDA
NORTRIPTYLINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: NORTRIPTYLINE
- Version: 01-August-2011
Alternate Names:

NORTRIPTYLINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: NORTRIPTYLINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiasthmatic agent

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: nortriptyline

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Perroud N et al., 2009, Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project., Neuropsychopharmacology

Roberts RL et al., 2002, A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression., Pharmacogenomics J

Keers R et al., 2011, Variation in GNB3 predicts response and adverse reactions to antidepressants., J Psychopharmacol

TTD: Nortriptyline
- Version: 2020.06.01
Alternate Names:

D04WFD TTD Drug ID

Drug Info:

Publications:
DTC: NORTRIPTYLINE
- Version: 02-September-2020
Alternate Names:

CHEMBL445 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL445
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Nortriptyline
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	CRx-170
Novel drug target	Established target
Trial Name	CRx-191

NORTRIPTYLINE Drug Record

NORTRIPTYLINE chembl:CHEMBL445 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25916525 20360315

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20970119

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CRx-170 Novel drug target Established target Trial Name CRx-191

PMIDs: 8863842 11502876 9537821 11092898 14744476 17018806

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20826553

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CRx-191 Novel drug target Established target Trial Name CRx-170

PMIDs: 12640215 9537821 14744476 14604448 16855451 11027924

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19641488

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12082591

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: NORTRIPTYLINE

Alternate Names: NORTRIPTYLINE Primary Drug Name

Drug Info: Drug Class antidepressive agents, tricyclic Year of Approval approved before 1982

Publications:

TdgClinicalTrial: NORTRIPTYLINE

Alternate Names:

Drug Info: Drug Indications antiasthmatic agent Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: nortriptyline

Alternate Names:

Drug Info:

TTD: Nortriptyline

Alternate Names: D04WFD TTD Drug ID

Drug Info:

Publications:

DTC: NORTRIPTYLINE

Alternate Names: CHEMBL445 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL445

Alternate Names:

Drug Info:

Publications:

FDA: Nortriptyline

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
25916525 20360315

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20970119

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-170

Novel drug target Established target

Trial Name CRx-191

PMIDs:
8863842 11502876 9537821 11092898 14744476 17018806

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
20826553

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-191

Novel drug target Established target

Trial Name CRx-170

PMIDs:
12640215 9537821 14744476 14604448 16855451 11027924

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
19641488

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12082591

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

NORTRIPTYLINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval approved before 1982

Drug Info:

Drug Indications antiasthmatic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D04WFD TTD Drug ID

Alternate Names:

CHEMBL445 ChEMBL Drug ID