DGIdb - NUTLIN-3 Drug Record

NUTLIN-3 chembl:CHEMBL191334

Alternate Names:

NUTLIN-3

Drug Info:

(0 More Sources)

Publications:

Yu S et al., 2009, Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction., J Med Chem
Ribeiro CJ et al., 2014, Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents., Bioorg Med Chem
Davidovich P et al., 2015, Discovery of Novel Isatin-Based p53 Inducers., ACS Med Chem Lett
Gomez-Monterrey I et al., 2010, Identification of the spiro(oxindole-3,3'-thiazolidine)-based derivatives as potential p53 activity modulators., J Med Chem
Tonsing-Carter et al., 2015, Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model., Mol. Cancer Ther.
Carrillo et al., 2015, Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells., Mol. Cancer Res.
Karan et al., 2016, Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53., Mol. Cancer Ther.
Hardcastle IR et al., 2011, Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency., J Med Chem
Vassilev LT et al., 2004, In vivo activation of the p53 pathway by small-molecule antagonists of MDM2., Science

NUTLIN-3 MDM2

Interaction Score: 13.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21314128 19928922 24268795 21058726 14704432

Sources:
DTC PharmGKB
NUTLIN-3 TP53

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy CTX-1 + Nutlin-3

Indication/Tumor Type acute myeloid leukemia

Response Type sensitive

PMIDs:
19928922 24268795 26288684 21058726 26494859 25964101 26883273

Sources:
DTC JAX-CKB

DTC: NUTLIN-3

Version: 02-September-2020

Alternate Names:

CHEMBL191334 ChEMBL Drug ID

Drug Info:

Publications:

Gomez-Monterrey I et al., 2010, Identification of the spiro(oxindole-3,3'-thiazolidine)-based derivatives as potential p53 activity modulators., J Med Chem

Hardcastle IR et al., 2011, Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency., J Med Chem

Ribeiro CJ et al., 2014, Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents., Bioorg Med Chem

PharmGKB: nutlin-3
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Vassilev LT et al., 2004, In vivo activation of the p53 pathway by small-molecule antagonists of MDM2., Science

JAX-CKB: Nutlin-3

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Carrillo et al., 2015, Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells., Mol. Cancer Res.

Tonsing-Carter et al., 2015, Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model., Mol. Cancer Ther.

Karan et al., 2016, Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53., Mol. Cancer Ther.

ChemblDrugs: chembl:CHEMBL191334
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

combination therapy	CTX-1 + Nutlin-3
Indication/Tumor Type	acute myeloid leukemia
Response Type	sensitive

NUTLIN-3 Drug Record

NUTLIN-3 chembl:CHEMBL191334

Alternate Names:

Drug Info:

Publications:

NUTLIN-3 MDM2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21314128 19928922 24268795 21058726 14704432

Sources: DTC PharmGKB

NUTLIN-3 TP53

Interaction Types & Directionality: n/a

Interaction Info: combination therapy CTX-1 + Nutlin-3 Indication/Tumor Type acute myeloid leukemia Response Type sensitive

PMIDs: 19928922 24268795 26288684 21058726 26494859 25964101 26883273

Sources: DTC JAX-CKB

DTC: NUTLIN-3

Alternate Names: CHEMBL191334 ChEMBL Drug ID

Drug Info:

PharmGKB: nutlin-3

Alternate Names:

Drug Info:

Publications: Vassilev LT et al., 2004, In vivo activation of the p53 pathway by small-molecule antagonists of MDM2., Science

JAX-CKB: Nutlin-3

Alternate Names:

Drug Info:

ChemblDrugs: chembl:CHEMBL191334

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21314128 19928922 24268795 21058726 14704432

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy CTX-1 + Nutlin-3

Indication/Tumor Type acute myeloid leukemia

Response Type sensitive

PMIDs:
19928922 24268795 26288684 21058726 26494859 25964101 26883273

Sources:
DTC JAX-CKB

Alternate Names:

CHEMBL191334 ChEMBL Drug ID

Publications:

Vassilev LT et al., 2004, In vivo activation of the p53 pathway by small-molecule antagonists of MDM2., Science