DGIdb - OLMESARTAN Drug Record

OLMESARTAN chembl:CHEMBL1516

Alternate Names:

OLMESARTAN
RNH-6270
4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-{[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL}-1H-IMIDAZOLE-5-CARBOXYLIC ACID
4-(HYDROXY-1-METHYLETHYL)-2-PROPYL-1-{[2'-(1H-TETRAZOL-5-YL)-1,1'-BIPHENYL-4-YL]METHYL}-1H-IMIDAZOLE-5-CARBOXYLIC ACID
rxcui:321064
chemidplus:144689-24-7
drugbank:00275
chembl:CHEMBL1516
pubchem.compound:158781

Drug Info:

Drug Indications	for treatment of glaucoma
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Year of Approval	2002
Drug Class	antihypertensive agents

(2 More Sources)

Publications:

Mire et al., 2005, A review of the structural and functional features of olmesartan medoxomil, an angiotensin receptor blocker., J. Cardiovasc. Pharmacol.
Koike et al., 2001, In vitro and in vivo pharmacology of olmesartan medoxomil, an angiotensin II type AT1 receptor antagonist., J Hypertens Suppl
Kreutz et al., 2006, Pharmacokinetics of olmesartan medoxomil plus hydrochlorothiazide combination in healthy subjects., Clin Drug Investig
Ochiai et al., 2006, Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling., J. Cardiovasc. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Warner et al., 2002, Olmesartan medoxomil., Drugs
Suwannakul S et al., 2008, Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism., J Hum Genet

OLMESARTAN AGTR1

Interaction Score: 6.51

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Direct Interaction? True

Specific Action of the Ligand Antagonist

PMIDs:
16220064 11451212 17163232 16775509 11752352 12076183

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
OLMESARTAN SLCO1B1

Interaction Score: 1.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18641915

Sources:
PharmGKB

TEND: OLMESARTAN
- Version: 01-August-2011
Alternate Names:

OLMESARTAN Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 2002

Publications:
TdgClinicalTrial: OLMESARTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:
PharmGKB: olmesartan
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Suwannakul S et al., 2008, Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism., J Hum Genet
GuideToPharmacology: 135650757
- Version: 29-September-2020
Alternate Names:

OLMESARTAN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblInteractions: CHEMBL1516
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1516
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Endogenous Drug?	False
Direct Interaction?	True
Specific Action of the Ligand	Antagonist

OLMESARTAN Drug Record

OLMESARTAN chembl:CHEMBL1516

Alternate Names:

Drug Info:

Publications:

OLMESARTAN AGTR1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Direct Interaction? True Specific Action of the Ligand Antagonist

PMIDs: 16220064 11451212 17163232 16775509 11752352 12076183

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

OLMESARTAN SLCO1B1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18641915

Sources: PharmGKB

TEND: OLMESARTAN

Alternate Names: OLMESARTAN Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 2002

Publications:

TdgClinicalTrial: OLMESARTAN

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: olmesartan

Alternate Names:

Drug Info:

Publications: Suwannakul S et al., 2008, Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism., J Hum Genet

GuideToPharmacology: 135650757

Alternate Names: OLMESARTAN GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblInteractions: CHEMBL1516

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1516

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Direct Interaction? True

Specific Action of the Ligand Antagonist

PMIDs:
16220064 11451212 17163232 16775509 11752352 12076183

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18641915

Sources:
PharmGKB

Alternate Names:

OLMESARTAN Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 2002

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

Suwannakul S et al., 2008, Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism., J Hum Genet

Alternate Names:

OLMESARTAN GuideToPharmacology Ligand Name