DGIdb - ONDANSETRON Drug Record

ONDANSETRON chembl:CHEMBL46 Approved

Alternate Names:

ZOFRAN
ZUPLENZ
A04AA01
GR-38032
ONDANSETRON
EUR-1025
ZOFRAN ODT
DESMETHYLONDANSETRON
GR-38032F

Drug Info:

Drug Indications	for treatment of obsessive compulsive disorder (OCD)
FDA Approval	approved
Drug Indications	antiemetic
FDA Approval	not approved
Drug Class	Small Molecule
Drug Indications	for treatment of sleep apnea
Year of Approval	1991
Drug Class	antiemetics

(4 More Sources)

Publications:

Carvalho et al., 2002, Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats., Horm. Metab. Res.
Gallardo Lara et al., 2009, Ondansetron: design and development of oral pharmaceutical suspensions., Pharmazie
Arcioni et al., 2002, Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans., Anesth. Analg.
Ramsook et al., 2002, A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis., Ann Emerg Med
Artaiz et al., 1998, Characterization of serotonergic mechanisms involved in the behavioural inhibition induced by 5-hydroxytryptophan in a modified light-dark test in mice., Behav Pharmacol
Gregory et al., 1998, 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy., Drugs
Szajewska et al., 2007, Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children., Aliment. Pharmacol. Ther.
Dimitrov, 2009, Effect of Ondansetron, a 5-HT(3) receptor antagonist, on fatigue in 2 veterans with hepatitis C., Prim Care Companion J Clin Psychiatry
Fortuño et al., 1999, CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum., J. Physiol. Biochem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Mohan et al., 1995, Ondansetron hydrochloride: a competitive serotonin 5-HT3 receptor blocker., Acta Crystallogr C
Gan, 2005, Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same?, CNS Drugs
Llácer et al., 2001, X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride., Drug Dev Ind Pharm
Kasho et al., 1998, Serotonin enhances the production of type IV collagen by human mesangial cells., Kidney Int.
He H et al., 2014, Association of ABCB1 polymorphisms with the efficacy of ondansetron in chemotherapy-induced nausea and vomiting., Clin Ther
Choi EM et al., 2010, Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting., Anaesthesia
Johnson BA et al., 2011, Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking., Am J Psychiatry
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Stamer UM et al., 2011, CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care., Anesth Analg
Netzer et al., 2002, Does intravenous ondansetron affect gastric emptying of a solid meal, gastric electrical activity or blood hormone levels in healthy volunteers?, Aliment. Pharmacol. Ther.
Ozmen et al., 2004, Effects of antiemetic drugs on glucose 6-phosphate dehydrogenase and some antioxidant enzymes., Pharmacol. Res.

ONDANSETRON PPY

Interaction Score: 4.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11856086

Sources:
NCI
ONDANSETRON HTR3A

Interaction Score: 2.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 3a (5-HT3a) receptor antagonist

Trial Name BGC20-0166

PMIDs:
11972287 19320280 12032025 11919526 10065930 9506240 17269994 20098535 10517265 11752352 8588861 15740177 11763467

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ONDANSETRON GSR

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15458770

Sources:
NCI
ONDANSETRON SLC6A4

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21247998

Sources:
PharmGKB
ONDANSETRON HTR2A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9767524

Sources:
NCI
ONDANSETRON CYP3A5

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21596874

Sources:
PharmGKB
ONDANSETRON ABCB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25012726 20707787

Sources:
PharmGKB
ONDANSETRON CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
ONDANSETRON CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

TEND: ONDANSETRON
- Version: 01-August-2011
Alternate Names:

ONDANSETRON Primary Drug Name

Drug Info:

Drug Class antiemetics

Year of Approval 1991

Publications:
TdgClinicalTrial: ONDANSETRON
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of sleep apnea

Drug Class Small Molecule

FDA Approval not approved

Publications:

NCI: ONDANSETRON

Version: 14-September-2017

Alternate Names:

C1119 NCI drug code

Drug Info:

Publications:

Netzer et al., 2002, Does intravenous ondansetron affect gastric emptying of a solid meal, gastric electrical activity or blood hormone levels in healthy volunteers?, Aliment. Pharmacol. Ther.

Ozmen et al., 2004, Effects of antiemetic drugs on glucose 6-phosphate dehydrogenase and some antioxidant enzymes., Pharmacol. Res.

Kasho et al., 1998, Serotonin enhances the production of type IV collagen by human mesangial cells., Kidney Int.

PharmGKB: ondansetron

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

He H et al., 2014, Association of ABCB1 polymorphisms with the efficacy of ondansetron in chemotherapy-induced nausea and vomiting., Clin Ther

Choi EM et al., 2010, Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting., Anaesthesia

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Ondansetron
- Version: 2020.06.01
Alternate Names:

D0K7WK TTD Drug ID

Drug Info:

Publications:
FDA: Ondansetron
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL46
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL46
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Serotonin 3a (5-HT3a) receptor antagonist
Trial Name	BGC20-0166

ONDANSETRON Drug Record

ONDANSETRON chembl:CHEMBL46 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11856086

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 3a (5-HT3a) receptor antagonist Trial Name BGC20-0166

PMIDs: 11972287 19320280 12032025 11919526 10065930 9506240 17269994 20098535 10517265 11752352 8588861 15740177 11763467

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15458770

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21247998

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9767524

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21596874

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25012726 20707787

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

TEND: ONDANSETRON

Alternate Names: ONDANSETRON Primary Drug Name

Drug Info: Drug Class antiemetics Year of Approval 1991

Publications:

TdgClinicalTrial: ONDANSETRON

Alternate Names:

Drug Info: Drug Indications for treatment of sleep apnea Drug Class Small Molecule FDA Approval not approved

Publications:

NCI: ONDANSETRON

Alternate Names: C1119 NCI drug code

Drug Info:

PharmGKB: ondansetron

Alternate Names:

Drug Info:

TTD: Ondansetron

Alternate Names: D0K7WK TTD Drug ID

Drug Info:

Publications:

FDA: Ondansetron

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL46

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL46

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
11856086

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 3a (5-HT3a) receptor antagonist

Trial Name BGC20-0166

PMIDs:
11972287 19320280 12032025 11919526 10065930 9506240 17269994 20098535 10517265 11752352 8588861 15740177 11763467

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
15458770

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21247998

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9767524

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21596874

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25012726 20707787

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Alternate Names:

ONDANSETRON Primary Drug Name

Drug Info:

Drug Class antiemetics

Year of Approval 1991

Drug Info:

Drug Indications for treatment of sleep apnea

Drug Class Small Molecule

FDA Approval not approved

Alternate Names:

C1119 NCI drug code

Alternate Names:

D0K7WK TTD Drug ID