DGIdb - OXYCODONE Drug Record

OXYCODONE chembl:CHEMBL656

Alternate Names:

N02AA05
IDS-NO-002
NSC-19043
OXICONE
PF-00345439
XTAMPZA ER
PTI-821
OXYCONTIN
OXYCODONE CII
PROLADONE
OXYCODONE
pubchem.compound:5284603
4,5Α-EPOXY-14-HYDROXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE
4,5ALPHA-EPOXY-14-HYDROXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE
OXYCODONE HYDROCHLORIDE
DIHYDROXYCODEINONE
OXYCODONUM
ROXICODONE®
OXICODONA
DIHYDRO-14-HYDROXYCODEINONE
DIHYDROHYDROXYCODEINONE
(-)-14-HYDROXYDIHYDROCODEINONE
4,5-EPOXY-14-HYDROXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE
chembl:CHEMBL656
drugbank:00497
chemidplus:76-42-6
rxcui:7804

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic
Drug Class	analgesics, opioid
Year of Approval	1939

(3 More Sources)

Publications:

Pu J et al., 2019, Correlation between gene polymorphism and opioid efficacy in patients with gastric or intestinal cancer., Eur Rev Med Pharmacol Sci
Cajanus K et al., 2014, How much oxycodone is needed for adequate analgesia after breast cancer surgery: effect of the OPRM1 118A>G polymorphism., J Pain
Naito T et al., 2011, CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone., J Clin Pharmacol
Ordóñez Gallego et al., 2007, Oxycodone: a pharmacological and clinical review., Clin Transl Oncol
Riley et al., 2008, Oxycodone: a review of its use in the management of pain., Curr Med Res Opin
Dietis et al., 2009, Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile., Br J Anaesth
Li J et al., 2018, The impact of UGT2B7 C802T and CYP3A4*1G polymorphisms on pain relief in cancer patients receiving oxycontin., Support Care Cancer
Hassan HE et al., 2013, Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone., Drug Metab Dispos
Aubrun F et al., 2018, Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study., Eur J Anaesthesiol
Matic M et al., 2017, Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement., Pharmacogenomics
Hronová K et al., 2016, Sufentanil and midazolam dosing and pharmacogenetic factors in pediatric analgosedation and withdrawal syndrome., Physiol Res
Elens L et al., 2016, Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation., Ther Drug Monit
De Gregori M et al., 2016, Human Genetic Variability Contributes to Postoperative Morphine Consumption., J Pain
Candiotti KA et al., 2014, Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain., Anesth Analg
Matic M et al., 2014, Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype., Pharmacogenomics
Cargnin S et al., 2013, An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans., J Pain
De Gregori M et al., 2013, Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain., Eur J Clin Pharmacol
Landau R et al., 2013, The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia., Anesth Analg
Klepstad P et al., 2011, Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients., Pain
Lötsch J et al., 2009, Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers., Pharmacogenet Genomics
Oosten AW et al., 2016, Opioid treatment failure in cancer patients: the role of clinical and genetic factors., Pharmacogenomics
Nielsen et al., 2007, Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain., Pain
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Galvan A et al., 2011, Multiple Loci modulate opioid therapy response for cancer pain., Clin Cancer Res

OXYCODONE RHBDF2

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21622719

Sources:
PharmGKB
OXYCODONE COMT

Interaction Score: 2.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29474345 28745577 28006928 27027462 26902643 25185591 25155931 23773341 23686330 23302985 21398039 19514130

Sources:
PharmGKB
OXYCODONE NR1I3

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23439660

Sources:
DTC
OXYCODONE UGT2B7

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29502154

Sources:
PharmGKB
OXYCODONE OPRD1

Interaction Score: 0.65

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name COL-003, sustained release oxycodone

Novel drug target Established target

Trial Name COL-172, extended-release oxycodone

PMIDs:
17525040 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
OXYCODONE OPRM1

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name COL-003, sustained release oxycodone

Novel drug target Established target

Trial Name PTI-801,Oxytrex

PMIDs:
31773688 25239082 21209234 17525040 18039433 19474215

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB
OXYCODONE OPRK1

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name transdermal oxycodone

Trial Name PTI-801,Oxytrex

Trial Name oxycodone, PTI-821,Remoxy

PMIDs:
27472837 17467904 17525040 18039433

Sources:
TdgClinicalTrial TEND PharmGKB
OXYCODONE CYP3A5

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21209234 18695978

Sources:
PharmGKB
OXYCODONE ABCB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21209234 19514130

Sources:
PharmGKB

TEND: OXYCODONE
- Version: 01-August-2011
Alternate Names:

OXYCODONE Primary Drug Name

Drug Info:

Year of Approval 1939

Drug Class analgesics, opioid

Publications:
TdgClinicalTrial: OXYCODONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: OXYCODONE
- Version: 02-September-2020
Alternate Names:

CHEMBL656 ChEMBL Drug ID

Drug Info:

Publications:

Hassan HE et al., 2013, Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone., Drug Metab Dispos

PharmGKB: oxycodone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Naito T et al., 2011, CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone., J Clin Pharmacol

Lötsch J et al., 2009, Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers., Pharmacogenet Genomics

Cajanus K et al., 2014, How much oxycodone is needed for adequate analgesia after breast cancer surgery: effect of the OPRM1 118A>G polymorphism., J Pain

TTD: Oxycodone
- Version: 2020.06.01
Alternate Names:

D03SKD TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL656
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL656
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	COL-003, sustained release oxycodone
Novel drug target	Established target
Trial Name	COL-172, extended-release oxycodone

Trial Name	transdermal oxycodone
Trial Name	PTI-801,Oxytrex
Trial Name	oxycodone, PTI-821,Remoxy

OXYCODONE Drug Record

OXYCODONE chembl:CHEMBL656

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21622719

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29474345 28745577 28006928 27027462 26902643 25185591 25155931 23773341 23686330 23302985 21398039 19514130

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23439660

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29502154

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name COL-003, sustained release oxycodone Novel drug target Established target Trial Name COL-172, extended-release oxycodone

PMIDs: 17525040 11752352

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name COL-003, sustained release oxycodone Novel drug target Established target Trial Name PTI-801,Oxytrex

PMIDs: 31773688 25239082 21209234 17525040 18039433 19474215

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name transdermal oxycodone Trial Name PTI-801,Oxytrex Trial Name oxycodone, PTI-821,Remoxy

PMIDs: 27472837 17467904 17525040 18039433

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21209234 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21209234 19514130

Sources: PharmGKB

TEND: OXYCODONE

Alternate Names: OXYCODONE Primary Drug Name

Drug Info: Year of Approval 1939 Drug Class analgesics, opioid

Publications:

TdgClinicalTrial: OXYCODONE

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small Molecule FDA Approval approved

Publications:

DTC: OXYCODONE

Alternate Names: CHEMBL656 ChEMBL Drug ID

Drug Info:

Publications: Hassan HE et al., 2013, Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone., Drug Metab Dispos

PharmGKB: oxycodone

Alternate Names:

Drug Info:

TTD: Oxycodone

Alternate Names: D03SKD TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL656

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL656

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21622719

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29474345 28745577 28006928 27027462 26902643 25185591 25155931 23773341 23686330 23302985 21398039 19514130

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23439660

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
29502154

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name COL-003, sustained release oxycodone

Novel drug target Established target

Trial Name COL-172, extended-release oxycodone

PMIDs:
17525040 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name COL-003, sustained release oxycodone

Novel drug target Established target

Trial Name PTI-801,Oxytrex

PMIDs:
31773688 25239082 21209234 17525040 18039433 19474215

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name transdermal oxycodone

Trial Name PTI-801,Oxytrex

Trial Name oxycodone, PTI-821,Remoxy

PMIDs:
27472837 17467904 17525040 18039433

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21209234 18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21209234 19514130

Sources:
PharmGKB

Alternate Names:

OXYCODONE Primary Drug Name

Drug Info:

Year of Approval 1939

Drug Class analgesics, opioid

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL656 ChEMBL Drug ID

Publications:

Hassan HE et al., 2013, Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone., Drug Metab Dispos

Alternate Names:

D03SKD TTD Drug ID