• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

OXYMETAZOLINE Drug Record

  • Summary
  • Interactions
  • Claims
  • OXYMETAZOLINE chembl:CHEMBL762 Approved

    Alternate Names:

    OCUCLEAR
    OXYMETAZOLINE
    AFRIN
    3-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-6-(1,1-DIMETHYLETHYL)-2,4-DIMETHYLPHENOL
    OXYMETOZOLINE
    2-(4-TERT-BUTYL-2,6-DIMETHYL-3-HYDROXYBENZYL)-2-IMIDAZOLINE
    OXIMETAZOLINUM
    AFRIN®
    6-T-BUTYL-3-(2-IMIDAZOLIN-2-YLMETHYL)-2,4-DIMETHYLPHENOL
    OXYMETAZOLINA
    OXYMETHAZOLINE
    6-TERT-BUTYL-3-(2-IMIDAZOLIN-2-YLMETHYL)-2,4-DIMETHYLPHENOL
    OXYMETAZOLINUM
    SCH-9384
    VICKS SINEX®
    chembl:CHEMBL762
    rxcui:7812
    drugbank:00935
    chemidplus:1491-59-4
    pubchem.compound:4636

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    Drug Class nasal decongestants
    Year of Approval approved before 1982
    (2 More Sources)

    Publications:

    González-Espinosa et al., 2001, Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor., Eur. J. Pharmacol.
    Yang et al., 1996, (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart., Eur. J. Pharmacol.
    Shibata et al., 2001, [Excitatory effect of noradrenaline on rat airway parasympathetic ganglion neurons]., Fukuoka Igaku Zasshi
    Furukawa et al., 1995, Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens., Br. J. Pharmacol.
    Deplanne et al., 1996, Functional characterization of alpha-1-adrenoceptor subtypes in the prostatic urethra and trigone of male rabbit., J. Pharmacol. Exp. Ther.
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
    Leprêtre et al., 1994, Alpha 2-adrenoceptors activate dihydropyridine-sensitive calcium channels via Gi-proteins and protein kinase C in rat portal vein myocytes., Pflugers Arch.
    MacKinnon et al., 1992, [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification., Br. J. Pharmacol.
    Mitrani et al., 2007, Role of the autonomic nervous system in the development of hyperinsulinemia by high-carbohydrate formula feeding to neonatal rats., Am. J. Physiol. Endocrinol. Metab.
  • OXYMETAZOLINE   ADRA2A

    Interaction Score: 1.39

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Trial Name OMS-103HP
    Novel drug target Established target

    PMIDs:
    16407989 7892112 1327384 17164433


    Sources:
    DTC TdgClinicalTrial TEND TTD

  • OXYMETAZOLINE   ADRA1A

    Interaction Score: 0.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name OMS-103HP
    Novel drug target Established target

    PMIDs:
    11527538 8894610 11774707 8564226 8768700


    Sources:
    TdgClinicalTrial TEND

  • OXYMETAZOLINE   G6PD

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Oxymetazoline,Tetracaine

    PMIDs:
    None found


    Sources:
    FDA

  • OXYMETAZOLINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OXYMETAZOLINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: OXYMETAZOLINE

    • Version: 01-August-2011

    Alternate Names:
    OXYMETAZOLINE Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class nasal decongestants

    Publications:

  • TdgClinicalTrial: OXYMETAZOLINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: OXYMETAZOLINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL762 ChEMBL Drug ID

    Drug Info:

    Publications:
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

  • TTD: Oxymetazoline

    • Version: 2020.06.01

    Alternate Names:
    D09EBS TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL762

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Oxymetazoline

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21