DGIdb - OXYMETAZOLINE Drug Record

OXYMETAZOLINE chembl:CHEMBL762 Approved

Alternate Names:

OCUCLEAR
OXYMETAZOLINE
AFRIN
3-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-6-(1,1-DIMETHYLETHYL)-2,4-DIMETHYLPHENOL
OXYMETOZOLINE
2-(4-TERT-BUTYL-2,6-DIMETHYL-3-HYDROXYBENZYL)-2-IMIDAZOLINE
OXIMETAZOLINUM
AFRIN®
6-T-BUTYL-3-(2-IMIDAZOLIN-2-YLMETHYL)-2,4-DIMETHYLPHENOL
OXYMETAZOLINA
OXYMETHAZOLINE
6-TERT-BUTYL-3-(2-IMIDAZOLIN-2-YLMETHYL)-2,4-DIMETHYLPHENOL
OXYMETAZOLINUM
SCH-9384
VICKS SINEX®
chembl:CHEMBL762
rxcui:7812
drugbank:00935
chemidplus:1491-59-4
pubchem.compound:4636

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic
Drug Class	nasal decongestants
Year of Approval	approved before 1982

(2 More Sources)

Publications:

González-Espinosa et al., 2001, Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor., Eur. J. Pharmacol.
Yang et al., 1996, (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart., Eur. J. Pharmacol.
Shibata et al., 2001, [Excitatory effect of noradrenaline on rat airway parasympathetic ganglion neurons]., Fukuoka Igaku Zasshi
Furukawa et al., 1995, Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens., Br. J. Pharmacol.
Deplanne et al., 1996, Functional characterization of alpha-1-adrenoceptor subtypes in the prostatic urethra and trigone of male rabbit., J. Pharmacol. Exp. Ther.
Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
Leprêtre et al., 1994, Alpha 2-adrenoceptors activate dihydropyridine-sensitive calcium channels via Gi-proteins and protein kinase C in rat portal vein myocytes., Pflugers Arch.
MacKinnon et al., 1992, [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification., Br. J. Pharmacol.
Mitrani et al., 2007, Role of the autonomic nervous system in the development of hyperinsulinemia by high-carbohydrate formula feeding to neonatal rats., Am. J. Physiol. Endocrinol. Metab.

OXYMETAZOLINE ADRA2A

Interaction Score: 1.39

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

PMIDs:
16407989 7892112 1327384 17164433

Sources:
DTC TdgClinicalTrial TEND TTD
OXYMETAZOLINE ADRA1A

Interaction Score: 0.99

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

PMIDs:
11527538 8894610 11774707 8564226 8768700

Sources:
TdgClinicalTrial TEND
OXYMETAZOLINE G6PD

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Oxymetazoline,Tetracaine

PMIDs:
None found

Sources:
FDA
OXYMETAZOLINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OXYMETAZOLINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: OXYMETAZOLINE
- Version: 01-August-2011
Alternate Names:

OXYMETAZOLINE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class nasal decongestants

Publications:
TdgClinicalTrial: OXYMETAZOLINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: OXYMETAZOLINE
- Version: 02-September-2020
Alternate Names:

CHEMBL762 ChEMBL Drug ID

Drug Info:

Publications:

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
TTD: Oxymetazoline
- Version: 2020.06.01
Alternate Names:

D09EBS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL762
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Oxymetazoline
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

partial agonist (activating)
agonist (activating)

Trial Name	OMS-103HP
Novel drug target	Established target

Trial Name	OMS-103HP
Novel drug target	Established target

OXYMETAZOLINE Drug Record

OXYMETAZOLINE chembl:CHEMBL762 Approved

Alternate Names:

Drug Info:

Publications:

OXYMETAZOLINE ADRA2A

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Trial Name OMS-103HP Novel drug target Established target

PMIDs: 16407989 7892112 1327384 17164433

Sources: DTC TdgClinicalTrial TEND TTD

OXYMETAZOLINE ADRA1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name OMS-103HP Novel drug target Established target

PMIDs: 11527538 8894610 11774707 8564226 8768700

Sources: TdgClinicalTrial TEND

OXYMETAZOLINE G6PD

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Oxymetazoline,Tetracaine

PMIDs: None found

Sources: FDA

OXYMETAZOLINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

OXYMETAZOLINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: OXYMETAZOLINE

Alternate Names: OXYMETAZOLINE Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class nasal decongestants

Publications:

TdgClinicalTrial: OXYMETAZOLINE

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small Molecule FDA Approval approved

Publications:

DTC: OXYMETAZOLINE

Alternate Names: CHEMBL762 ChEMBL Drug ID

Drug Info:

Publications: Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

TTD: Oxymetazoline

Alternate Names: D09EBS TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL762

Alternate Names:

Drug Info:

Publications:

FDA: Oxymetazoline

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

PMIDs:
16407989 7892112 1327384 17164433

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

PMIDs:
11527538 8894610 11774707 8564226 8768700

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Oxymetazoline,Tetracaine

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

OXYMETAZOLINE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class nasal decongestants

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL762 ChEMBL Drug ID

Publications:

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

Alternate Names:

D09EBS TTD Drug ID