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OXYTOCIN Drug Record

  • Summary
  • Interactions
  • Claims
  • OXYTOCIN chembl:CHEMBL395429 Approved

    Alternate Names:

    TTA-121
    SYNTOMETRINE
    SYNTOCINON
    OXYTOCIN
    PITOCIN
    ORASTHIN
    SYT670
    UNIPROT:P01178
    SID50111741
    SID29217903
    pubchem.compound:439302
    rxcui:7824
    chemidplus:50-56-6
    chembl:CHEMBL395429
    drugbank:00107

    Drug Info:

    Year of Approval 1980
    Drug Class labor inducing agents
    FDA Approval approved
    Drug Class peptide
    Drug Indications analgesic
    (2 More Sources)

    Publications:

    Burns et al., 2001, Cellular mechanisms by which oxytocin mediates ovine endometrial prostaglandin F2alpha synthesis: role of G(i) proteins and mitogen-activated protein kinases., Biol. Reprod.
    Frantz et al., 2010, Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxytocin receptor agonist., J. Med. Chem.
    Spyranti et al., 2010, In position 7 L- and D-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights., Amino Acids
    Ahn et al., In vivo activity of the potent oxytocin antagonist on uterine activity in the rat., In Vivo
    Gimpl et al., 2008, Oxytocin receptors: ligand binding, signalling and cholesterol dependence., Prog. Brain Res.
    Furman et al., 2011, Variant in oxytocin receptor gene is associated with amygdala volume., Psychoneuroendocrinology
    Land et al., Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA., Nature
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Rao et al., 1992, The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization., Cytogenet. Cell Genet.
    Sirotkin et al., 2004, Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A., J. Endocrinol.
    Rinaman et al., 2002, GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Wehrenberg et al., 1994, Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary., Proc. Natl. Acad. Sci. U.S.A.
  • OXYTOCIN   OXT

    Interaction Score: 27.48

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    6687626 17016423 1486803


    Sources:
    TEND

  • OXYTOCIN   OXTR

    Interaction Score: 4.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name TI-001, intranasal oxytocin
    Novel drug target Established target
    Mechanism of Interaction Oxytocin receptor agonist

    PMIDs:
    20104850 20108008 15646817 18655883 21208749


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • OXYTOCIN   NR5A1

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8108428


    Sources:
    NCI

  • OXYTOCIN   GCG

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12069935


    Sources:
    NCI

  • OXYTOCIN   AVPR1B

    Interaction Score: 0.46

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OXYTOCIN   AVPR1A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OXYTOCIN   AVPR2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OXYTOCIN   MAPK8

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11566737


    Sources:
    NCI

  • OXYTOCIN   BAX

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15590985


    Sources:
    NCI

  • TEND: OXYTOCIN

    • Version: 01-August-2011

    Alternate Names:
    OXYTOCIN Primary Drug Name

    Drug Info:
    Drug Class labor inducing agents
    Year of Approval 1980

    Publications:

  • TdgClinicalTrial: OXYTOCIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class peptide
    FDA Approval approved

    Publications:

  • NCI: OXYTOCIN

    • Version: 14-September-2017

    Alternate Names:
    C724 NCI drug code

    Drug Info:

    Publications:
    Wehrenberg et al., 1994, Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary., Proc. Natl. Acad. Sci. U.S.A.
    Sirotkin et al., 2004, Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A., J. Endocrinol.
    Rinaman et al., 2002, GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.

  • TTD: Oxytocin

    • Version: 2020.06.01

    Alternate Names:
    D0M3FJ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL395429

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL395429

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21