DGIdb - OXYTOCIN Drug Record

OXYTOCIN chembl:CHEMBL395429 Approved

Alternate Names:

TTA-121
SYNTOMETRINE
SYNTOCINON
OXYTOCIN
PITOCIN
ORASTHIN
SYT670
UNIPROT:P01178
SID50111741
SID29217903
pubchem.compound:439302
rxcui:7824
chemidplus:50-56-6
chembl:CHEMBL395429
drugbank:00107

Drug Info:

Year of Approval	1980
Drug Class	labor inducing agents
FDA Approval	approved
Drug Class	peptide
Drug Indications	analgesic

(3 More Sources)

Publications:

Burns et al., 2001, Cellular mechanisms by which oxytocin mediates ovine endometrial prostaglandin F2alpha synthesis: role of G(i) proteins and mitogen-activated protein kinases., Biol. Reprod.
Frantz et al., 2010, Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxytocin receptor agonist., J. Med. Chem.
Spyranti et al., 2010, In position 7 L- and D-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights., Amino Acids
Ahn et al., In vivo activity of the potent oxytocin antagonist on uterine activity in the rat., In Vivo
Gimpl et al., 2008, Oxytocin receptors: ligand binding, signalling and cholesterol dependence., Prog. Brain Res.
Furman et al., 2011, Variant in oxytocin receptor gene is associated with amygdala volume., Psychoneuroendocrinology
Land et al., Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA., Nature
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Rao et al., 1992, The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization., Cytogenet. Cell Genet.
Sirotkin et al., 2004, Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A., J. Endocrinol.
Rinaman et al., 2002, GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Wehrenberg et al., 1994, Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary., Proc. Natl. Acad. Sci. U.S.A.

OXYTOCIN OXT

Interaction Score: 28.35

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
6687626 17016423 1486803

Sources:
TEND
OXYTOCIN OXTR

Interaction Score: 3.36

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Direct Interaction? True

PMIDs:
20104850 20108008 15646817 18655883 21208749

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
OXYTOCIN NR5A1

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8108428

Sources:
NCI
OXYTOCIN GCG

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12069935

Sources:
NCI
OXYTOCIN AVPR1B

Interaction Score: 0.79

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD
OXYTOCIN AVPR1A

Interaction Score: 0.59

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD
OXYTOCIN AVPR2

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD
OXYTOCIN MAPK8

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11566737

Sources:
NCI
OXYTOCIN BAX

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15590985

Sources:
NCI

GuideToPharmacology: 135651848
- Version: 29-September-2020
Alternate Names:

OXT Gene Symbol (for Endogenous Peptides)

OXYTOCIN GuideToPharmacology Ligand Name

Oxt Gene Symbol (for Endogenous Peptides)

Drug Info:

Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Publications:
TEND: OXYTOCIN
- Version: 01-August-2011
Alternate Names:

OXYTOCIN Primary Drug Name

Drug Info:

Drug Class labor inducing agents

Year of Approval 1980

Publications:
TdgClinicalTrial: OXYTOCIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class peptide

FDA Approval approved

Publications:

NCI: OXYTOCIN

Version: 14-September-2017

Alternate Names:

C724 NCI drug code

Drug Info:

Publications:

Wehrenberg et al., 1994, Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary., Proc. Natl. Acad. Sci. U.S.A.

Sirotkin et al., 2004, Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A., J. Endocrinol.

Rinaman et al., 2002, GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.

TTD: Oxytocin
- Version: 2020.06.01
Alternate Names:

D0M3FJ TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL395429
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL395429
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Full agonist
Endogenous Drug?	True
Direct Interaction?	True

OXT	Gene Symbol (for Endogenous Peptides)
OXYTOCIN	GuideToPharmacology Ligand Name
Oxt	Gene Symbol (for Endogenous Peptides)

OXYTOCIN Drug Record

OXYTOCIN chembl:CHEMBL395429 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 6687626 17016423 1486803

Sources: TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True Direct Interaction? True

PMIDs: 20104850 20108008 15646817 18655883 21208749

Sources: TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8108428

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12069935

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11566737

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15590985

Sources: NCI

GuideToPharmacology: 135651848

Alternate Names: OXT Gene Symbol (for Endogenous Peptides) OXYTOCIN GuideToPharmacology Ligand Name Oxt Gene Symbol (for Endogenous Peptides)

Drug Info: Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Publications:

TEND: OXYTOCIN

Alternate Names: OXYTOCIN Primary Drug Name

Drug Info: Drug Class labor inducing agents Year of Approval 1980

Publications:

TdgClinicalTrial: OXYTOCIN

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class peptide FDA Approval approved

Publications:

NCI: OXYTOCIN

Alternate Names: C724 NCI drug code

Drug Info:

TTD: Oxytocin

Alternate Names: D0M3FJ TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL395429

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL395429

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

binder

PMIDs:
6687626 17016423 1486803

Sources:
TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Direct Interaction? True

PMIDs:
20104850 20108008 15646817 18655883 21208749

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
8108428

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12069935

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
11566737

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15590985

Sources:
NCI

Alternate Names:

OXT Gene Symbol (for Endogenous Peptides)

OXYTOCIN GuideToPharmacology Ligand Name

Oxt Gene Symbol (for Endogenous Peptides)

Drug Info:

Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Alternate Names:

OXYTOCIN Primary Drug Name

Drug Info:

Drug Class labor inducing agents

Year of Approval 1980

Drug Info:

Drug Indications analgesic

Drug Class peptide

FDA Approval approved

Alternate Names:

C724 NCI drug code

Alternate Names:

D0M3FJ TTD Drug ID