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PALIPERIDONE Drug Record

  • Summary
  • Interactions
  • Claims
  • PALIPERIDONE chembl:CHEMBL1621 Approved

    Alternate Names:

    TREVICTA
    XEPLION
    R-76477
    RO-76477
    PALIPERIDONE
    INVEGA
    RO-92670
    9-HYDROXYRISPERIDONE
    INVEGA®
    drugbank:01267
    rxcui:679314
    chembl:CHEMBL1621
    chemidplus:144598-75-4
    pubchem.compound:115237

    Drug Info:

    Drug Class antipsychotic agents
    Year of Approval 2006
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antipsychotic agent
    (4 More Sources)

    Publications:

    Wang D et al., 2015, Large-scale candidate gene study to identify genetic risk factors predictive of paliperidone treatment response in patients with schizophrenia., Pharmacogenet Genomics
    Regenthal et al., 2005, D2 dopamine receptor occupancy, risperidone plasma level and extrapyramidal motor symptoms in previously drug-free schizophrenic patients., Int J Clin Pharmacol Ther
    Cohen, Risperidone., Pharmacotherapy
    Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)
    Remington et al., 2006, A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone., Am J Psychiatry
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
    Yamada et al., 2002, Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy., Synapse
    Zhang JP et al., 2016, Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis., Schizophr Bull
    Czerwensky F et al., 2013, MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?, Int J Neuropsychopharmacol
    Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
    Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry
    Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry
    He et al., 1995, A pharmacological, pharmacokinetic and clinical overview of risperidone, a new antipsychotic that blocks serotonin 5-HT2 and dopamine D2 receptors., Int Clin Psychopharmacol
    Boerth et al., 2005, Interpreting serum risperidone concentrations., Pharmacotherapy
    Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
  • PALIPERIDONE   MC4R

    Interaction Score: 2.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • PALIPERIDONE   SH2B1

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • PALIPERIDONE   RABEP1

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • PALIPERIDONE   HTR2A

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name paliperidone ER, paliperidone palmitate
    Novel drug target Established target
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    7520908 7524043 7531353 7542676 11132243 12211096


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PALIPERIDONE   ERBB4

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25714000


    Sources:
    PharmGKB

  • PALIPERIDONE   DRD2

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name paliperidone ER, paliperidone palmitate
    Mechanism of Interaction Dopamine D2 receptor antagonist

    PMIDs:
    16119512 7524043 7531353 16513859 11752352 11132243 12211096


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PALIPERIDONE   DRD1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7520908 7531353


    Sources:
    DTC

  • PALIPERIDONE   CYP2D6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15767244


    Sources:
    PharmGKB FDA

  • PALIPERIDONE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PALIPERIDONE

    • Version: 01-August-2011

    Alternate Names:
    PALIPERIDONE Primary Drug Name

    Drug Info:
    Year of Approval 2006
    Drug Class antipsychotic agents

    Publications:

  • TdgClinicalTrial: PALIPERIDONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antipsychotic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • PharmGKB: paliperidone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Wang D et al., 2015, Large-scale candidate gene study to identify genetic risk factors predictive of paliperidone treatment response in patients with schizophrenia., Pharmacogenet Genomics
    Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
    Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry

  • DTC: PALIPERIDONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1621 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Paliperidone

    • Version: 2020.06.01

    Alternate Names:
    D0B3UJ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1621

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1621

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Paliperidone

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21