DGIdb - PALIPERIDONE Drug Record

PALIPERIDONE chembl:CHEMBL1621 Approved

Alternate Names:

TREVICTA
XEPLION
R-76477
RO-76477
PALIPERIDONE
INVEGA
RO-92670
9-HYDROXYRISPERIDONE
INVEGA®
drugbank:01267
rxcui:679314
chembl:CHEMBL1621
chemidplus:144598-75-4
pubchem.compound:115237

Drug Info:

Drug Class	antipsychotic agents
Year of Approval	2006
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antipsychotic agent

(4 More Sources)

Publications:

Wang D et al., 2015, Large-scale candidate gene study to identify genetic risk factors predictive of paliperidone treatment response in patients with schizophrenia., Pharmacogenet Genomics
Regenthal et al., 2005, D2 dopamine receptor occupancy, risperidone plasma level and extrapyramidal motor symptoms in previously drug-free schizophrenic patients., Int J Clin Pharmacol Ther
Cohen, Risperidone., Pharmacotherapy
Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)
Remington et al., 2006, A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone., Am J Psychiatry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
Yamada et al., 2002, Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy., Synapse
Zhang JP et al., 2016, Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis., Schizophr Bull
Czerwensky F et al., 2013, MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?, Int J Neuropsychopharmacol
Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry
Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry
He et al., 1995, A pharmacological, pharmacokinetic and clinical overview of risperidone, a new antipsychotic that blocks serotonin 5-HT2 and dopamine D2 receptors., Int Clin Psychopharmacol
Boerth et al., 2005, Interpreting serum risperidone concentrations., Pharmacotherapy
Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene

PALIPERIDONE MC4R

Interaction Score: 2.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27217270 23920449 23799528 22566560

Sources:
PharmGKB
PALIPERIDONE SH2B1

Interaction Score: 1.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
PALIPERIDONE RABEP1

Interaction Score: 1.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
PALIPERIDONE HTR2A

Interaction Score: 0.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name paliperidone ER, paliperidone palmitate

Novel drug target Established target

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs:
7520908 7524043 7531353 7542676 11132243 12211096

Sources:
TdgClinicalTrial ChemblInteractions TEND
PALIPERIDONE ERBB4

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25714000

Sources:
PharmGKB
PALIPERIDONE DRD2

Interaction Score: 0.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name paliperidone ER, paliperidone palmitate

Mechanism of Interaction Dopamine D2 receptor antagonist

PMIDs:
16119512 7524043 7531353 16513859 11752352 11132243 12211096

Sources:
TdgClinicalTrial ChemblInteractions TEND
PALIPERIDONE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7520908 7531353

Sources:
DTC
PALIPERIDONE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15767244

Sources:
PharmGKB FDA
PALIPERIDONE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PALIPERIDONE
- Version: 01-August-2011
Alternate Names:

PALIPERIDONE Primary Drug Name

Drug Info:

Year of Approval 2006

Drug Class antipsychotic agents

Publications:
TdgClinicalTrial: PALIPERIDONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antipsychotic agent

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: paliperidone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Wang D et al., 2015, Large-scale candidate gene study to identify genetic risk factors predictive of paliperidone treatment response in patients with schizophrenia., Pharmacogenet Genomics

Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene

Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry

DTC: PALIPERIDONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1621 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Paliperidone
- Version: 2020.06.01
Alternate Names:

D0B3UJ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1621
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1621
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Paliperidone
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	paliperidone ER, paliperidone palmitate
Novel drug target	Established target
Mechanism of Interaction	Serotonin 2a (5-HT2a) receptor antagonist

PALIPERIDONE Drug Record

PALIPERIDONE chembl:CHEMBL1621 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27217270 23920449 23799528 22566560

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28694205

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28694205

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name paliperidone ER, paliperidone palmitate Novel drug target Established target Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs: 7520908 7524043 7531353 7542676 11132243 12211096

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25714000

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name paliperidone ER, paliperidone palmitate Mechanism of Interaction Dopamine D2 receptor antagonist

PMIDs: 16119512 7524043 7531353 16513859 11752352 11132243 12211096

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7520908 7531353

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15767244

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PALIPERIDONE

Alternate Names: PALIPERIDONE Primary Drug Name

Drug Info: Year of Approval 2006 Drug Class antipsychotic agents

Publications:

TdgClinicalTrial: PALIPERIDONE

Alternate Names:

Drug Info: Drug Indications antipsychotic agent Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: paliperidone

Alternate Names:

Drug Info:

DTC: PALIPERIDONE

Alternate Names: CHEMBL1621 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Paliperidone

Alternate Names: D0B3UJ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1621

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1621

Alternate Names:

Drug Info:

Publications:

FDA: Paliperidone

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
27217270 23920449 23799528 22566560

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name paliperidone ER, paliperidone palmitate

Novel drug target Established target

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs:
7520908 7524043 7531353 7542676 11132243 12211096

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
25714000

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name paliperidone ER, paliperidone palmitate

Mechanism of Interaction Dopamine D2 receptor antagonist

PMIDs:
16119512 7524043 7531353 16513859 11752352 11132243 12211096

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7520908 7531353

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15767244

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PALIPERIDONE Primary Drug Name

Drug Info:

Year of Approval 2006

Drug Class antipsychotic agents

Drug Info:

Drug Indications antipsychotic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1621 ChEMBL Drug ID

Alternate Names:

D0B3UJ TTD Drug ID