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PENTOBARBITAL Drug Record

  • Summary
  • Interactions
  • Claims
  • PENTOBARBITAL chembl:CHEMBL448

    Alternate Names:

    PENTOBARBITAL CALCIUM
    NSC-28708
    NEMBUTAL
    MEBUMAL
    MEBUBARBITAL
    PENTOBARBITAL CII
    PENTOBARBITAL
    PENTOBARBITAL SODIUM
    NSC 28708
    NEMBUTAL®
    5-ETHYL-5-(1-METHYLBUTYL)BARBITURIC ACID
    PENTOBARBITONE
    5-ETHYL-5-(SEC-PENTYL)BARBITURIC ACID
    PENTOBARBITURIC ACID
    5-ETHYL-5-(1-METHYL-BUTYL)-PYRIMIDINE-2,4,6-TRIONE
    (RS)-PENTOBARBITAL
    5-ETHYL-5-(1-METHYLBUTYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
    (±)-PENTOBARBITAL
    pubchem.compound:4737
    chemidplus:76-74-4
    chembl:CHEMBL448
    drugbank:00312
    rxcui:8004

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Year of Approval approved before 1982
    Drug Class hypnotics and sedatives
    Drug Categories cytochrome p-450 cyp2a6 inducers (strong)
    Drug Groups investigational
    Drug Categories anticholinergic agents
    Drug Categories anticonvulsants
    Drug Categories cytochrome p-450 cyp3a inducers (strong)
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories nicotinic antagonists
    (2 More Sources)

    Publications:

    Feigenspan et al., 2004, Electrophysiological properties of mouse horizontal cell GABAA receptors., J. Neurophysiol.
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Steinbach et al., 2001, Modulation of GABA(A) receptor channel gating by pentobarbital., J. Physiol. (Lond.)
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Davies et al., 2001, Pressure-sensitive and -insensitive coupling in gamma-aminobutyric acid(A) receptors., Psychopharmacology (Berl.)
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Rahman et al., 2006, GABA-site antagonism and pentobarbital actions do not depend on the alpha-subunit type in the recombinant rat GABA receptor., Acta Physiol (Oxf)
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Daniell, 1994, Effect of anesthetic and convulsant barbiturates on N-methyl-D-aspartate receptor-mediated calcium flux in brain membrane vesicles., Pharmacology
    Kobayashi K et al., 2004, Key structural features of ligands for activation of human pregnane X receptor., Drug Metab Dispos
  • PENTOBARBITAL   GRIK2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PENTOBARBITAL   GABRA1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

    PMIDs:
    15240758 14579514 11744750 11264449 11752352 17139284 10209232 11605100 17016423 10487207 16866778


    Sources:
    TEND TdgClinicalTrial TTD DrugBank ChemblInteractions

  • PENTOBARBITAL   CHRNA4

    Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PENTOBARBITAL   GRIA2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PENTOBARBITAL   CHRNA7

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PENTOBARBITAL   GABRA6

    Interaction Score: 0.2

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • PENTOBARBITAL   GABRA5

    Interaction Score: 0.18

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • PENTOBARBITAL   GABRA2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • PENTOBARBITAL   GABRA3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • PENTOBARBITAL   GABRA4

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    10209232


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • PENTOBARBITAL   GRIN1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7862741


    Sources:
    DrugBank

  • PENTOBARBITAL   GABRQ

    Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GABRP

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GABRE

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GABRD

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GABRG1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GABRB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GABRB3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GABRG2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GABRB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   NR1I2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    15039302


    Sources:
    DrugBank

  • PENTOBARBITAL   GABRG3

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DrugBank: DB00312

    • Version: 5.1.7

    Alternate Names:
    PENTOBARBITAL DrugBank Drug Name
    76-74-4 CAS Number
    Cafergot Pb Sup Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Feigenspan et al., 2004, Electrophysiological properties of mouse horizontal cell GABAA receptors., J. Neurophysiol.
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Steinbach et al., 2001, Modulation of GABA(A) receptor channel gating by pentobarbital., J. Physiol. (Lond.)

  • TEND: PENTOBARBITAL

    • Version: 01-August-2011

    Alternate Names:
    PENTOBARBITAL Primary Drug Name

    Drug Info:
    Drug Class hypnotics and sedatives
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: PENTOBARBITAL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • TTD: Pentobarbital

    • Version: 2020.06.01

    Alternate Names:
    D0F0YZ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL448

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL448

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21