DGIdb - PENTOSTATIN Drug Record

PENTOSTATIN chembl:CHEMBL1580 ApprovedAntineoplasticImmunotherapy

Alternate Names:

YK-176
NIPENT
NSC-218321
PD-81565
PENTOSTATIN
CI-825
NIPENT®
CO-VIDARABINE
PENTOSTATINUM
DEOXYCOFORMYCIN
PENTOSTATINE
PENTOSTATINA
2'-DEOXYCOFORMYCIN
pubchem.compound:439693
drugbank:00552
chemidplus:53910-25-1
chembl:CHEMBL1580
rxcui:8011

Drug Info:

Drug Class	antineoplastic agents
Year of Approval	1991
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antineoplastic agent

(2 More Sources)

Publications:

Cabanillas, 2000, Purine nucleoside analogs in indolent non-Hodgkin's lymphoma., Oncology (Williston Park, N.Y.)
Newman et al., 2007, Natural products as sources of new drugs over the last 25 years., J. Nat. Prod.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Jackson et al., 1986, The biochemical pharmacology of (2'-R)-chloropentostatin, a novel inhibitor of adenosine deaminase., Adv. Enzyme Regul.
Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.

PENTOSTATIN ADA

Interaction Score: 22.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name pentostatin,Nipent

Novel drug target Established target

Mechanism of Interaction Adenosine deaminase inhibitor

PMIDs:
10887639 17309302 11752352 2433905

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
PENTOSTATIN PRKAA1

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11969266

Sources:
NCI

TEND: PENTOSTATIN
- Version: 01-August-2011
Alternate Names:

PENTOSTATIN Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antineoplastic agents

Publications:
TdgClinicalTrial: PENTOSTATIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small Molecule

FDA Approval approved

Publications:
NCI: DEOXYCOFORMYCIN
- Version: 14-September-2017
Alternate Names:

C732 NCI drug code

Drug Info:

Publications:

Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.
TTD: Pentostatin
- Version: 2020.06.01
Alternate Names:

D0T3AD TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1580
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1580
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	pentostatin,Nipent
Novel drug target	Established target
Mechanism of Interaction	Adenosine deaminase inhibitor

PENTOSTATIN Drug Record

PENTOSTATIN chembl:CHEMBL1580 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

PENTOSTATIN ADA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name pentostatin,Nipent Novel drug target Established target Mechanism of Interaction Adenosine deaminase inhibitor

PMIDs: 10887639 17309302 11752352 2433905

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

PENTOSTATIN PRKAA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11969266

Sources: NCI

TEND: PENTOSTATIN

Alternate Names: PENTOSTATIN Primary Drug Name

Drug Info: Year of Approval 1991 Drug Class antineoplastic agents

Publications:

TdgClinicalTrial: PENTOSTATIN

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: DEOXYCOFORMYCIN

Alternate Names: C732 NCI drug code

Drug Info:

Publications: Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.

TTD: Pentostatin

Alternate Names: D0T3AD TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1580

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1580

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name pentostatin,Nipent

Novel drug target Established target

Mechanism of Interaction Adenosine deaminase inhibitor

PMIDs:
10887639 17309302 11752352 2433905

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
11969266

Sources:
NCI

Alternate Names:

PENTOSTATIN Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antineoplastic agents

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C732 NCI drug code

Publications:

Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.

Alternate Names:

D0T3AD TTD Drug ID