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PENTOSTATIN Drug Record

  • Summary
  • Interactions
  • Claims
  • PENTOSTATIN chembl:CHEMBL1580 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    YK-176
    NIPENT
    NSC-218321
    PD-81565
    PENTOSTATIN
    CI-825
    NIPENT®
    CO-VIDARABINE
    PENTOSTATINUM
    DEOXYCOFORMYCIN
    PENTOSTATINE
    PENTOSTATINA
    2'-DEOXYCOFORMYCIN
    pubchem.compound:439693
    drugbank:00552
    chemidplus:53910-25-1
    chembl:CHEMBL1580
    rxcui:8011

    Drug Info:

    Drug Class antineoplastic agents
    Year of Approval 1991
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antineoplastic agent
    (2 More Sources)

    Publications:

    Cabanillas, 2000, Purine nucleoside analogs in indolent non-Hodgkin's lymphoma., Oncology (Williston Park, N.Y.)
    Newman et al., 2007, Natural products as sources of new drugs over the last 25 years., J. Nat. Prod.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Jackson et al., 1986, The biochemical pharmacology of (2'-R)-chloropentostatin, a novel inhibitor of adenosine deaminase., Adv. Enzyme Regul.
    Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.
  • PENTOSTATIN   ADA

    Interaction Score: 22.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name pentostatin,Nipent
    Novel drug target Established target
    Mechanism of Interaction Adenosine deaminase inhibitor

    PMIDs:
    10887639 17309302 11752352 2433905


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PENTOSTATIN   PRKAA1

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11969266


    Sources:
    NCI

  • TEND: PENTOSTATIN

    • Version: 01-August-2011

    Alternate Names:
    PENTOSTATIN Primary Drug Name

    Drug Info:
    Year of Approval 1991
    Drug Class antineoplastic agents

    Publications:

  • TdgClinicalTrial: PENTOSTATIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: DEOXYCOFORMYCIN

    • Version: 14-September-2017

    Alternate Names:
    C732 NCI drug code

    Drug Info:

    Publications:
    Downs et al., 2002, A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes., Dev. Biol.

  • TTD: Pentostatin

    • Version: 2020.06.01

    Alternate Names:
    D0T3AD TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1580

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1580

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21