DGIdb - PERIFOSINE Drug Record

PERIFOSINE chembl:CHEMBL372764 Antineoplastic

Alternate Names:

NSC-639966
KRX-0401
PERIFOSINE

Drug Info:

FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antineoplastic agent

(3 More Sources)

Publications:

Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.
Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.
Shome D et al., 2008, Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine., Ophthalmology

PERIFOSINE AKT1

Interaction Score: 1.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name perifosine, KRX-0401

Novel drug target Novel Target

Indication/Tumor Type ovarian clear cell carcinoma

PMIDs:
25519148 18201764

Sources:
TALC TdgClinicalTrial JAX-CKB MyCancerGenomeClinicalTrial
PERIFOSINE AKT2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name perifosine, KRX-0401

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PERIFOSINE AKT3

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name perifosine, KRX-0401

PMIDs:
None found

Sources:
TdgClinicalTrial
PERIFOSINE PIK3CA

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19706758

Sources:
CIViC
PERIFOSINE PIK3CG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TdgClinicalTrial: PERIFOSINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class small molecule

FDA Approval not approved

Publications:
JAX-CKB: Perifosine
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.

CIViC: PERIFOSINE

Version: 14-September-2020

Alternate Names:

Drug Info:

Publications:

Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.

TALC: PERIFOSINE
- Version: 12-May-2016
Alternate Names:

PERIFOSINE Primary Drug Name

PERIFOSINE Drug Generic Name

KRX-0401 Drug Synonym

Drug Info:

Publications:
TTD: Perifosine
- Version: 2020.06.01
Alternate Names:

D0R1VU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL372764
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: PERIFOSINE
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:

Trial Name	perifosine, KRX-0401
Novel drug target	Novel Target
Indication/Tumor Type	ovarian clear cell carcinoma

PERIFOSINE	Primary Drug Name
PERIFOSINE	Drug Generic Name
KRX-0401	Drug Synonym

PERIFOSINE Drug Record

PERIFOSINE chembl:CHEMBL372764 Antineoplastic

Alternate Names:

Drug Info:

Publications:

PERIFOSINE AKT1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name perifosine, KRX-0401 Novel drug target Novel Target Indication/Tumor Type ovarian clear cell carcinoma

PMIDs: 25519148 18201764

Sources: TALC TdgClinicalTrial JAX-CKB MyCancerGenomeClinicalTrial

PERIFOSINE AKT2

Interaction Types & Directionality: n/a

Interaction Info: Trial Name perifosine, KRX-0401 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

PERIFOSINE AKT3

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name perifosine, KRX-0401

PMIDs: None found

Sources: TdgClinicalTrial

PERIFOSINE PIK3CA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19706758

Sources: CIViC

PERIFOSINE PIK3CG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TdgClinicalTrial: PERIFOSINE

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class small molecule FDA Approval not approved

Publications:

JAX-CKB: Perifosine

Alternate Names:

Drug Info:

Publications: Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.

CIViC: PERIFOSINE

Alternate Names:

Drug Info:

Publications: Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.

TALC: PERIFOSINE

Alternate Names: PERIFOSINE Primary Drug Name PERIFOSINE Drug Generic Name KRX-0401 Drug Synonym

Drug Info:

Publications:

TTD: Perifosine

Alternate Names: D0R1VU TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL372764

Alternate Names:

Drug Info:

Publications:

MyCancerGenomeClinicalTrial: PERIFOSINE

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name perifosine, KRX-0401

Novel drug target Novel Target

Indication/Tumor Type ovarian clear cell carcinoma

PMIDs:
25519148 18201764

Sources:
TALC TdgClinicalTrial JAX-CKB MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name perifosine, KRX-0401

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name perifosine, KRX-0401

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
19706758

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Drug Info:

Drug Indications antineoplastic agent

Drug Class small molecule

FDA Approval not approved

Publications:

Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.

Publications:

Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.

Alternate Names:

PERIFOSINE Primary Drug Name

PERIFOSINE Drug Generic Name

KRX-0401 Drug Synonym

Alternate Names:

D0R1VU TTD Drug ID