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PERINDOPRIL Drug Record

  • Summary
  • Interactions
  • Claims
  • PERINDOPRIL chembl:CHEMBL1581 Approved

    Alternate Names:

    PERINDOPRIL
    S-9490
    MCN-A-2833
    (2S,3AS,7AS)-1-[(2S)-2-{[(2S)-1-ETHOXY-1-OXOPENTAN-2-YL]AMINO}PROPANOYL]OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID
    PERINDOPRILUM
    COVERSYL®
    PRETERAX®
    drugbank:00790
    pubchem.compound:107807
    rxcui:54552
    chembl:CHEMBL1581
    chemidplus:82834-16-0

    Drug Info:

    FDA Approval 1993
    Drug Class small molecule
    Drug Indications Antihypertensive Agents
    Year of Approval 1993
    Drug Class antihypertensive agents
    (1 More Sources)

    Publications:

    He H et al., 2005, A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril., Ann Hum Biol
    Ha SK et al., 2000, ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus., Nephrol Dial Transplant
    Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Brugts et al., 2009, Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease., Expert Rev Cardiovasc Ther
    Alfakih et al., 2006, Perindopril., Expert Opin Pharmacother
    Benetos A et al., 1996, Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals., Hypertension
    Brugts JJ et al., 2010, Tailored therapy of ACE inhibitors in stable coronary artery disease: pharmacogenetic profiling of treatment benefit., Pharmacogenomics
  • PERINDOPRIL   BDKRB1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20712529


    Sources:
    PharmGKB

  • PERINDOPRIL   ACE

    Interaction Score: 2.81

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15788353 11007831 11929321 11752352 19379059 16370923


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • PERINDOPRIL   AGTR1

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8952600 20712529


    Sources:
    PharmGKB

  • PERINDOPRIL   G6PD

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TEND: PERINDOPRIL

    • Version: 01-August-2011

    Alternate Names:
    PERINDOPRIL Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval 1993

    Publications:

  • TdgClinicalTrial: PERINDOPRIL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Class small molecule
    FDA Approval 1993

    Publications:

  • PharmGKB: perindopril

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Brugts JJ et al., 2010, Tailored therapy of ACE inhibitors in stable coronary artery disease: pharmacogenetic profiling of treatment benefit., Pharmacogenomics
    Benetos A et al., 1996, Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals., Hypertension
    He H et al., 2005, A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril., Ann Hum Biol

  • TTD: Perindopril

    • Version: 2020.06.01

    Alternate Names:
    D03KYG TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1581

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21