DGIdb - PERINDOPRIL Drug Record

PERINDOPRIL chembl:CHEMBL1581 Approved

Alternate Names:

PERINDOPRIL
S-9490
MCN-A-2833
(2S,3AS,7AS)-1-[(2S)-2-{[(2S)-1-ETHOXY-1-OXOPENTAN-2-YL]AMINO}PROPANOYL]OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID
PERINDOPRILUM
COVERSYL®
PRETERAX®
drugbank:00790
pubchem.compound:107807
rxcui:54552
chembl:CHEMBL1581
chemidplus:82834-16-0

Drug Info:

FDA Approval	1993
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Year of Approval	1993
Drug Class	antihypertensive agents

(1 More Sources)

Publications:

He H et al., 2005, A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril., Ann Hum Biol
Ha SK et al., 2000, ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus., Nephrol Dial Transplant
Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Brugts et al., 2009, Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease., Expert Rev Cardiovasc Ther
Alfakih et al., 2006, Perindopril., Expert Opin Pharmacother
Benetos A et al., 1996, Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals., Hypertension
Brugts JJ et al., 2010, Tailored therapy of ACE inhibitors in stable coronary artery disease: pharmacogenetic profiling of treatment benefit., Pharmacogenomics

PERINDOPRIL BDKRB1

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20712529

Sources:
PharmGKB
PERINDOPRIL ACE

Interaction Score: 2.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15788353 11007831 11929321 11752352 19379059 16370923

Sources:
TdgClinicalTrial TEND PharmGKB TTD
PERINDOPRIL AGTR1

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8952600 20712529

Sources:
PharmGKB
PERINDOPRIL G6PD

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: PERINDOPRIL
- Version: 01-August-2011
Alternate Names:

PERINDOPRIL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1993

Publications:
TdgClinicalTrial: PERINDOPRIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1993

Publications:

PharmGKB: perindopril

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Brugts JJ et al., 2010, Tailored therapy of ACE inhibitors in stable coronary artery disease: pharmacogenetic profiling of treatment benefit., Pharmacogenomics

Benetos A et al., 1996, Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals., Hypertension

He H et al., 2005, A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril., Ann Hum Biol

TTD: Perindopril
- Version: 2020.06.01
Alternate Names:

D03KYG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1581
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

PERINDOPRIL Drug Record

PERINDOPRIL chembl:CHEMBL1581 Approved

Alternate Names:

Drug Info:

Publications:

PERINDOPRIL BDKRB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20712529

Sources: PharmGKB

PERINDOPRIL ACE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15788353 11007831 11929321 11752352 19379059 16370923

Sources: TdgClinicalTrial TEND PharmGKB TTD

PERINDOPRIL AGTR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8952600 20712529

Sources: PharmGKB

PERINDOPRIL G6PD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TEND: PERINDOPRIL

Alternate Names: PERINDOPRIL Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1993

Publications:

TdgClinicalTrial: PERINDOPRIL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Class small molecule FDA Approval 1993

Publications:

PharmGKB: perindopril

Alternate Names:

Drug Info:

TTD: Perindopril

Alternate Names: D03KYG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1581

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20712529

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15788353 11007831 11929321 11752352 19379059 16370923

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
8952600 20712529

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

PERINDOPRIL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1993

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1993

Alternate Names:

D03KYG TTD Drug ID