PEXIDARTINIB Drug Record
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PEXIDARTINIB chembl:CHEMBL3813873 ApprovedAntineoplastic
Alternate Names:
CML-261 PEXIDARTINIB PLX-3397 PLX3397 Drug Info:
Drug Class Kinase Inhibitors Pharmaceutical Developer Plexxicon Source Reported Drug Name(s) PLX3397 Drug Class Kinase Inhibitor Drug Type small molecule Drug Groups approved Drug Groups investigational Drug Categories amines Drug Categories antineoplastic agents Drug Categories cytochrome p-450 cyp2b6 inducers Drug Categories cytochrome p-450 cyp2b6 inducers (strength unknown) Drug Categories cytochrome p-450 cyp2b6 inhibitors Drug Categories cytochrome p-450 cyp2b6 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp2c9 inhibitors Drug Categories cytochrome p-450 cyp2c9 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp3a inducers Drug Categories cytochrome p-450 cyp3a inhibitors Drug Categories cytochrome p-450 cyp3a substrates Drug Categories cytochrome p-450 cyp3a4 inducers Drug Categories cytochrome p-450 cyp3a4 inducers (weak) Drug Categories cytochrome p-450 cyp3a4 inhibitors Drug Categories cytochrome p-450 cyp3a4 inhibitors (weak) Drug Categories cytochrome p-450 cyp3a4 substrates Drug Categories cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 enzyme inducers Drug Categories cytochrome p-450 enzyme inhibitors Drug Categories cytochrome p-450 substrates Drug Categories hepatotoxic agents Drug Categories mate 1 inhibitors Drug Categories mate 2 inhibitors Drug Categories mate inhibitors Drug Categories narrow therapeutic index drugs Drug Categories oatp1b1/slco1b1 inhibitors Drug Categories oatp1b3 inhibitors Drug Categories pyridines Drug Categories tyrosine kinase inhibitors Drug Categories ugt1a1 inhibitors Drug Categories ugt1a4 substrates Publications:
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Interaction Score: 4.37
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Interaction Score: 0.75
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes Approval Status Phase I -
Interaction Score: 0.52
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Indication/Tumor Type gastrointestinal stromal tumor Response Type sensitive Approval Status Preclinical - Cell line xenograft -
Interaction Score: 0.45
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Reported Cancer Type Prostate Indication/Tumor Type Advanced Solid Tumor Response Type resistant -
Interaction Score: 0.44
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Interaction Score: 0.4
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.21
Interaction Types & Directionality:
n/a Interaction Info:
Drug family Pan-TK inhibitor Alteration NF1:del Alteration NF1:. -
Interaction Score: 0.12
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.1
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Interaction Score: 0.09
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Interaction Score: 0.06
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.05
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.03
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition
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Alternate Names:
PEXIDARTINIB DrugBank Drug Name 1029044-16-3 CAS Number Turalio Drug Brand Drug Info:
Drug Type small molecule Drug Groups approved Drug Groups investigational -
- Version: 20-Jun-2017
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PLX3397 Development Name PLX108-01 Development Name Drug Info:
Drug Class Kinase Inhibitors Publications:
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- Version: 25-July-2013
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PLX3397 Drug Trade Name PLX3397 Drug Development Name Drug Info:
Drug Class Kinase Inhibitor Source Reported Drug Name(s) PLX3397 Pharmaceutical Developer Plexxicon Publications:
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Drug Info:
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- Version: 14-September-2020
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D09TAB TTD Drug ID Drug Info:
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- Version: 29-September-2020
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PEXIDARTINIB GuideToPharmacology Ligand Name Drug Info:
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- Version: ChEMBL_27
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Drug Info:
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- Version: chembl_23
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