• Interaction Score: 0.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy PF3644022 + PF-477736
    Indication/Tumor Type Advanced Solid Tumor
    Response Type predicted – sensitive

    PMIDs:
    26140595


    Sources:
    JAX-CKB

  • Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Chk1 inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Approval Status Preclinical - Cell culture
    Indication/Tumor Type Advanced Solid Tumor
    Indication/Tumor Type colon cancer

    PMIDs:
    26140595


    Sources:
    JAX-CKB

  • Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy PF3644022 + PF-477736
    Indication/Tumor Type urinary bladder cancer
    Response Type predicted – sensitive

    PMIDs:
    26140595


    Sources:
    JAX-CKB

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy PF3644022 + PF-477736
    Indication/Tumor Type Advanced Solid Tumor
    Response Type no benefit

    PMIDs:
    26140595


    Sources:
    JAX-CKB

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy MK-1775 + PF-00477736
    Indication/Tumor Type colon cancer
    Response Type sensitive

    PMIDs:
    22713237


    Sources:
    JAX-CKB