DGIdb - PHENELZINE Drug Record

PHENELZINE chembl:CHEMBL1089 Approved

Alternate Names:

NARDIL
PHENELZINE
PHENELZINE SULFATE
NARDIL®
drugbank:00780
pubchem.compound:3675
chembl:CHEMBL1089
chemidplus:51-71-8
rxcui:8123

Drug Info:

Year of Approval	1961
Drug Class	antidepressive agents
FDA Approval	1961
Drug Class	small molecule
Drug Indications	Antidepressive Agents

(1 More Sources)

Publications:

McIntyre et al., 2006, The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms., Expert Opin Drug Saf
Nolen, 2003, [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]., Ned Tijdschr Geneeskd
Volz et al., 1998, Monoamine oxidase inhibitors. A perspective on their use in the elderly., Drugs Aging
Wooters et al., 2007, The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats., Behav Pharmacol
Chiche et al., 2009, Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Pickar et al., 1982, Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients., Arch. Gen. Psychiatry
Chenu et al., 2009, Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area., Int. J. Neuropsychopharmacol.
MacKenzie et al., 2008, Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition., Neurochem. Res.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PHENELZINE MAOA

Interaction Score: 3.27

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND
PHENELZINE MAOB

Interaction Score: 1.89

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16370964 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND TTD
PHENELZINE RAB9A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENELZINE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PHENELZINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENELZINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENELZINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENELZINE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PHENELZINE
- Version: 01-August-2011
Alternate Names:

PHENELZINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents

Year of Approval 1961

Publications:
TdgClinicalTrial: PHENELZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents

Drug Class small molecule

FDA Approval 1961

Publications:
DTC: PHENELZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1089 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Phenelzine
- Version: 2020.06.01
Alternate Names:

D0P9AC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1089
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

antagonist (inhibitory)
inhibitor (inhibitory)

Trial Name	-
Novel drug target	Established target

antagonist (inhibitory)
inhibitor (inhibitory)

Trial Name	-
Novel drug target	Established target

PHENELZINE Drug Record

PHENELZINE chembl:CHEMBL1089 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16370964 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PHENELZINE

Alternate Names: PHENELZINE Primary Drug Name

Drug Info: Drug Class antidepressive agents Year of Approval 1961

Publications:

TdgClinicalTrial: PHENELZINE

Alternate Names:

Drug Info: Drug Indications Antidepressive Agents Drug Class small molecule FDA Approval 1961

Publications:

DTC: PHENELZINE

Alternate Names: CHEMBL1089 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Phenelzine

Alternate Names: D0P9AC TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1089

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16370964 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PHENELZINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents

Year of Approval 1961

Drug Info:

Drug Indications Antidepressive Agents

Drug Class small molecule

FDA Approval 1961

Alternate Names:

CHEMBL1089 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0P9AC TTD Drug ID