DGIdb - PHENELZINE Drug Record

PHENELZINE chembl:CHEMBL1089 Approved

Alternate Names:

NARDIL
PHENELZINE
PHENELZINE SULFATE
NARDIL®
drugbank:00780
pubchem.compound:3675
chembl:CHEMBL1089
chemidplus:51-71-8
rxcui:8123

Drug Info:

Year of Approval	1961
Drug Class	antidepressive agents
FDA Approval	1961
Drug Class	small molecule
Drug Indications	Antidepressive Agents

(2 More Sources)

Publications:

McIntyre et al., 2006, The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms., Expert Opin Drug Saf
Nolen, 2003, [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]., Ned Tijdschr Geneeskd
Volz et al., 1998, Monoamine oxidase inhibitors. A perspective on their use in the elderly., Drugs Aging
Wooters et al., 2007, The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats., Behav Pharmacol
Chiche et al., 2009, Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Pickar et al., 1982, Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients., Arch. Gen. Psychiatry
Chenu et al., 2009, Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area., Int. J. Neuropsychopharmacol.
MacKenzie et al., 2008, Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition., Neurochem. Res.
Lizcano et al., 1996, Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives., Biochem. Pharmacol.
Tipnis et al., Purification and characterization of semicarbazide-sensitive amine oxidase from porcine aorta., Cell. Mol. Biol. (Noisy-le-grand)
Biasi et al., 1995, [Multiple osseous avascular necrosis in a patient with systemic lupus erythematosus with antiphospholipid antibody positivity]., Recenti Prog Med
Kumar et al., 1998, Allylamine and beta-aminopropionitrile induced aortic medial necrosis: mechanisms of synergism., Toxicology
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PHENELZINE AOC3

Interaction Score: 5.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17768678 8694842 1483111 19201819 8539478 9570326

Sources:
GuideToPharmacology
PHENELZINE MAOA

Interaction Score: 2.03

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Irreversible inhibition

PMIDs:
16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND GuideToPharmacology
PHENELZINE MAOB

Interaction Score: 1.25

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Irreversible inhibition

PMIDs:
16370964 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
PHENELZINE CYP2C8

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENELZINE SLC6A2

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENELZINE SLC6A4

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
PHENELZINE SLC6A3

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENELZINE RAB9A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENELZINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PHENELZINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENELZINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENELZINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENELZINE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PHENELZINE
- Version: 01-August-2011
Alternate Names:

PHENELZINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents

Year of Approval 1961

Publications:
TdgClinicalTrial: PHENELZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents

Drug Class small molecule

FDA Approval 1961

Publications:
DTC: PHENELZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1089 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
GuideToPharmacology: 178103840
- Version: 29-September-2020
Alternate Names:

PHENELZINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Phenelzine
- Version: 2020.06.01
Alternate Names:

D0P9AC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1089
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Irreversible inhibition

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Irreversible inhibition

antagonist (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

PHENELZINE Drug Record

PHENELZINE chembl:CHEMBL1089 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 17768678 8694842 1483111 19201819 8539478 9570326

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Irreversible inhibition

PMIDs: 16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Irreversible inhibition

PMIDs: 16370964 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PHENELZINE

Alternate Names: PHENELZINE Primary Drug Name

Drug Info: Drug Class antidepressive agents Year of Approval 1961

Publications:

TdgClinicalTrial: PHENELZINE

Alternate Names:

Drug Info: Drug Indications Antidepressive Agents Drug Class small molecule FDA Approval 1961

Publications:

DTC: PHENELZINE

Alternate Names: CHEMBL1089 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

GuideToPharmacology: 178103840

Alternate Names: PHENELZINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Phenelzine

Alternate Names: D0P9AC TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1089

Alternate Names:

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17768678 8694842 1483111 19201819 8539478 9570326

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Irreversible inhibition

PMIDs:
16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Irreversible inhibition

PMIDs:
16370964 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PHENELZINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents

Year of Approval 1961

Drug Info:

Drug Indications Antidepressive Agents

Drug Class small molecule

FDA Approval 1961

Alternate Names:

CHEMBL1089 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

PHENELZINE GuideToPharmacology Ligand Name

Alternate Names:

D0P9AC TTD Drug ID