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PHENELZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • PHENELZINE chembl:CHEMBL1089 Approved

    Alternate Names:

    NARDIL
    PHENELZINE
    PHENELZINE SULFATE
    NARDIL®
    drugbank:00780
    pubchem.compound:3675
    chembl:CHEMBL1089
    chemidplus:51-71-8
    rxcui:8123

    Drug Info:

    Year of Approval 1961
    Drug Class antidepressive agents
    FDA Approval 1961
    Drug Class small molecule
    Drug Indications Antidepressive Agents
    (1 More Sources)

    Publications:

    McIntyre et al., 2006, The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms., Expert Opin Drug Saf
    Nolen, 2003, [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]., Ned Tijdschr Geneeskd
    Volz et al., 1998, Monoamine oxidase inhibitors. A perspective on their use in the elderly., Drugs Aging
    Wooters et al., 2007, The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats., Behav Pharmacol
    Chiche et al., 2009, Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes., Mol. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Pickar et al., 1982, Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients., Arch. Gen. Psychiatry
    Chenu et al., 2009, Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area., Int. J. Neuropsychopharmacol.
    MacKenzie et al., 2008, Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition., Neurochem. Res.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
  • PHENELZINE   MAOA

    Interaction Score: 3.27

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056


    Sources:
    TdgClinicalTrial TEND

  • PHENELZINE   MAOB

    Interaction Score: 1.89

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16370964 14574774 9829163 17912044 19201819 11752352 7092487 18700056


    Sources:
    TdgClinicalTrial TEND TTD

  • PHENELZINE   RAB9A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENELZINE   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PHENELZINE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENELZINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENELZINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENELZINE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PHENELZINE

    • Version: 01-August-2011

    Alternate Names:
    PHENELZINE Primary Drug Name

    Drug Info:
    Drug Class antidepressive agents
    Year of Approval 1961

    Publications:

  • TdgClinicalTrial: PHENELZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antidepressive Agents
    Drug Class small molecule
    FDA Approval 1961

    Publications:

  • DTC: PHENELZINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1089 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Phenelzine

    • Version: 2020.06.01

    Alternate Names:
    D0P9AC TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1089

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21