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PHENTOLAMINE Drug Record

  • Summary
  • Interactions
  • Claims
  • PHENTOLAMINE chembl:CHEMBL597 Approved

    Alternate Names:

    PHENTOLAMINE
    REGITINA
    DIBASIN
    PHENTOLAMINE MESYLATE
    REGITINE®
    2-(N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL)IMIDAZOLINE
    PHENTOLAMIN
    ROGITINE®
    FENTOLAMIN
    VESOMAX
    PHENTOLAMINUM
    FENTOLAMINA
    chemidplus:50-60-2
    chembl:CHEMBL597
    drugbank:00692
    pubchem.compound:5775
    rxcui:8153

    Drug Info:

    FDA Approval 1952
    Drug Indications Antihypertensive Agents
    FDA Approval approved
    Drug Class small molecule
    Drug Indications for treatment of erectile dysfunction
    Year of Approval 1952
    Drug Class antihypertensive agents
    (2 More Sources)

    Publications:

    Saeed et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade., J. Cardiovasc. Pharmacol.
    Giussani et al., 1995, Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero., J. Physiol. (Lond.)
    Bylund, 1992, Subtypes of alpha 1- and alpha 2-adrenergic receptors., FASEB J.
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
    Trendelenburg et al., 2003, Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient mice., Br. J. Pharmacol.
    Polak et al., 2005, Dynamic strength training improves insulin sensitivity and functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose tissue of obese subjects., Diabetologia
    Blandizzi et al., 2003, Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by alpha2-adrenoceptors in the presence of experimental colitis., Br. J. Pharmacol.
    Vonend et al., 2007, Alpha(2A)-adrenoceptors regulate sympathetic transmitter release in mice kidneys., Br. J. Pharmacol.
    Molderings et al., 2000, Species-specific pharmacological properties of human alpha(2A)-adrenoceptors., Hypertension
    Egert et al., 1999, Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart., Circ. Res.
    Proks et al., 1997, Phentolamine block of KATP channels is mediated by Kir6.2., Proc. Natl. Acad. Sci. U.S.A.
    Nakata et al., 1985, Alpha-adrenergic regulation of the activity of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy., Eur. J. Pharmacol.
    Bijman et al., 1987, Modulation of placental alkaline phosphatase activity and cytokeratins in human HN-1 cells by butyrate, retinoic acid, catecholamines and histamine., Br. J. Cancer
  • PHENTOLAMINE   ALPP

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2444242


    Sources:
    NCI

  • PHENTOLAMINE   ADRA2A

    Interaction Score: 1.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name aviptadil,Invicorp
    Novel drug target Established target
    Trial Name -

    PMIDs:
    16407989 12721093 1346768 16273345 7562640 12770936 17115069 10988273 6176798


    Sources:
    DTC TdgClinicalTrial TEND

  • PHENTOLAMINE   KCNJ11

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9326676


    Sources:
    NCI

  • PHENTOLAMINE   TYMS

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2866100


    Sources:
    NCI

  • PHENTOLAMINE   ADRA1A

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name aviptadil,Invicorp
    Novel drug target Established target

    PMIDs:
    6176798 7562640 1346768


    Sources:
    TdgClinicalTrial

  • PHENTOLAMINE   SLC2A4

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10381893


    Sources:
    NCI

  • PHENTOLAMINE   DRD2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PHENTOLAMINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENTOLAMINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PHENTOLAMINE

    • Version: 01-August-2011

    Alternate Names:
    PHENTOLAMINE Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval 1952

    Publications:

  • TdgClinicalTrial: PHENTOLAMINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of erectile dysfunction
    Drug Class small molecule
    FDA Approval approved

    Publications:

  • NCI: PHENTOLAMINE

    • Version: 14-September-2017

    Alternate Names:
    C38691 NCI drug code

    Drug Info:

    Publications:
    Nakata et al., 1985, Alpha-adrenergic regulation of the activity of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy., Eur. J. Pharmacol.
    Bijman et al., 1987, Modulation of placental alkaline phosphatase activity and cytokeratins in human HN-1 cells by butyrate, retinoic acid, catecholamines and histamine., Br. J. Cancer
    Proks et al., 1997, Phentolamine block of KATP channels is mediated by Kir6.2., Proc. Natl. Acad. Sci. U.S.A.

  • DTC: PHENTOLAMINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL597 ChEMBL Drug ID

    Drug Info:

    Publications:
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

  • TTD: Phentolamine

    • Version: 2020.06.01

    Alternate Names:
    D01JUF TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL597

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21