• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

PHENYLBUTANOIC ACID Drug Record

  • Summary
  • Interactions
  • Claims
  • PHENYLBUTANOIC ACID chembl:CHEMBL1469 Approved

    Alternate Names:

    PHENYLBUTYRATE
    PHENYLBUTANOIC ACID
    OMEGA-PHENYLBUTANOIC ACID
    GAMMA-PHENYL-N-BUTYRIC ACID
    BENZENEBUTYRIC ACID
    4-PHENYL-N-BUTYRIC ACID
    GAMMA-PHENYLBUTYRIC ACID
    PBA
    4-PHENYLBUTANOIC ACID
    OMEGA-PHENYLBUTYRIC ACID
    chemidplus:1821-12-1
    pubchem.compound:4775
    chembl:CHEMBL1469
    drugbank:02000
    rxcui:1546447

    Drug Info:

    (0 More Sources)

    Publications:

    Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
    Ng et al., 2000, Phenylbutyrate-induced apoptosis and differential expression of Bcl-2, Bax, p53 and Fas in human prostate cancer cell lines., Anal. Quant. Cytol. Histol.
    Andreassi et al., 2004, Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy., Eur. J. Hum. Genet.
    Munshi et al., 2005, Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity., Clin. Cancer Res.
  • PHENYLBUTANOIC ACID   XRCC5

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16000590


    Sources:
    NCI

  • PHENYLBUTANOIC ACID   HDAC11

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC TTD

  • PHENYLBUTANOIC ACID   HDAC9

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC10

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC7

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC5

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC8

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC4

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC6

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   BCL2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10696460


    Sources:
    NCI

  • PHENYLBUTANOIC ACID   SMN1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14560316


    Sources:
    NCI

  • NCI: PHENYLBUTYRATE

    • Version: 14-September-2017

    Alternate Names:
    C1440 NCI drug code

    Drug Info:

    Publications:
    Ng et al., 2000, Phenylbutyrate-induced apoptosis and differential expression of Bcl-2, Bax, p53 and Fas in human prostate cancer cell lines., Anal. Quant. Cytol. Histol.
    Andreassi et al., 2004, Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy., Eur. J. Hum. Genet.
    Munshi et al., 2005, Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity., Clin. Cancer Res.

  • DTC: PHENYLBUTANOIC ACID

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1469 ChEMBL Drug ID

    Drug Info:

    Publications:
    Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett

  • TTD: Phenylbutyrate

    • Version: 2020.06.01

    Alternate Names:
    D0B7CH TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1469

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21