DGIdb - PHENYLBUTAZONE Drug Record

PHENYLBUTAZONE chembl:CHEMBL101

Alternate Names:

EQUIPHAR
ELMEDAL
ANTADOL
AZOLID
BUTACOTE
PRO-BUTE
BUTAJECT
BUTAZOLIDIN
DIPHENYLBUTAZONE
PHENYLBUTAZONE
3,5-DIOXO-1,2-DIPHENYL-4-N-BUTYLPYRAZOLIDINE
4-N-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE
4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE
FENILBUTAZONA
PHENBUTAZONE
PHENYLBUTAZONUM
BUTAZOLIDINE®
4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE
1,2-DIPHENYL-3,5-DIOXO-4-N-BUTYLPYRAZOLINE
PHENYLBUTAZON
BUT137
chemidplus:50-33-9
chembl:CHEMBL101
pubchem.compound:4781
rxcui:8160
drugbank:00812

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	NSAID
Drug Class	anti-inflammatory agents, non-steroidal
Year of Approval	approved before 1982

(3 More Sources)

Publications:

Tobin et al., 1986, Phenylbutazone in the horse: a review., J. Vet. Pharmacol. Ther.
Marnett et al., 1984, Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom., Mol. Pharmacol.
Reed et al., 1985, Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism., Mol. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Arifah et al., 2002, Pharmacodynamics and pharmacokinetics of phenylbutazone in calves., J. Vet. Pharmacol. Ther.
Beretta et al., 2005, COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis., Pharmacol. Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Takada et al., 2004, Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation., Oncogene
Morton et al., 2005, Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis., Res. Vet. Sci.
Zitova et al., 2010, Analysis of activity and inhibition of oxygen-dependent enzymes by optical respirometry on the LightCycler system., Anal. Biochem.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Buttar D et al., 2010, A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions., Bioorg Med Chem

PHENYLBUTAZONE PTGIS

Interaction Score: 36.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3517382 6434940 3917545 17016423 17139284

Sources:
TdgClinicalTrial TEND
PHENYLBUTAZONE FPR1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENYLBUTAZONE PTGS2

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
12213119 15939622 11752352 15489888

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
PHENYLBUTAZONE ALB

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20869876

Sources:
DTC
PHENYLBUTAZONE PTGS1

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
15939622 15563928 19849999

Sources:
ChemblInteractions
PHENYLBUTAZONE NR1I2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PHENYLBUTAZONE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PHENYLBUTAZONE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PHENYLBUTAZONE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PHENYLBUTAZONE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PHENYLBUTAZONE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PHENYLBUTAZONE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PHENYLBUTAZONE
- Version: 01-August-2011
Alternate Names:

PHENYLBUTAZONE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class anti-inflammatory agents, non-steroidal

Publications:
TdgClinicalTrial: PHENYLBUTAZONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications NSAID

Drug Class small molecule

FDA Approval Approved before 1982

Publications:

DTC: PHENYLBUTAZONE

Version: 02-September-2020

Alternate Names:

CHEMBL101 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Buttar D et al., 2010, A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions., Bioorg Med Chem

TTD: Phenylbutazone
- Version: 2020.06.01
Alternate Names:

D07VHR TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL101
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL101
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: phenylbutazone
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Cyclooxygenase inhibitor

Mechanism of Interaction	Cyclooxygenase inhibitor
Direct Interaction	yes

PHENYLBUTAZONE Drug Record

PHENYLBUTAZONE chembl:CHEMBL101

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 3517382 6434940 3917545 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs: 12213119 15939622 11752352 15489888

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20869876

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes

PMIDs: 15939622 15563928 19849999

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PHENYLBUTAZONE

Alternate Names: PHENYLBUTAZONE Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class anti-inflammatory agents, non-steroidal

Publications:

TdgClinicalTrial: PHENYLBUTAZONE

Alternate Names:

Drug Info: Drug Indications NSAID Drug Class small molecule FDA Approval Approved before 1982

Publications:

DTC: PHENYLBUTAZONE

Alternate Names: CHEMBL101 ChEMBL Drug ID

Drug Info:

TTD: Phenylbutazone

Alternate Names: D07VHR TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL101

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL101

Alternate Names:

Drug Info:

Publications:

PharmGKB: phenylbutazone

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3517382 6434940 3917545 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
12213119 15939622 11752352 15489888

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
20869876

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
15939622 15563928 19849999

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PHENYLBUTAZONE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class anti-inflammatory agents, non-steroidal

Drug Info:

Drug Indications NSAID

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

CHEMBL101 ChEMBL Drug ID

Alternate Names:

D07VHR TTD Drug ID