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PHENYLBUTAZONE Drug Record

  • Summary
  • Interactions
  • Claims
  • PHENYLBUTAZONE chembl:CHEMBL101

    Alternate Names:

    EQUIPHAR
    ELMEDAL
    ANTADOL
    AZOLID
    BUTACOTE
    PRO-BUTE
    BUTAJECT
    BUTAZOLIDIN
    DIPHENYLBUTAZONE
    PHENYLBUTAZONE
    3,5-DIOXO-1,2-DIPHENYL-4-N-BUTYLPYRAZOLIDINE
    4-N-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE
    4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE
    FENILBUTAZONA
    PHENBUTAZONE
    PHENYLBUTAZONUM
    BUTAZOLIDINEĀ®
    4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE
    1,2-DIPHENYL-3,5-DIOXO-4-N-BUTYLPYRAZOLINE
    PHENYLBUTAZON
    BUT137
    chemidplus:50-33-9
    chembl:CHEMBL101
    pubchem.compound:4781
    rxcui:8160
    drugbank:00812

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications NSAID
    Drug Class anti-inflammatory agents, non-steroidal
    Year of Approval approved before 1982
    (3 More Sources)

    Publications:

    Tobin et al., 1986, Phenylbutazone in the horse: a review., J. Vet. Pharmacol. Ther.
    Marnett et al., 1984, Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom., Mol. Pharmacol.
    Reed et al., 1985, Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism., Mol. Pharmacol.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Arifah et al., 2002, Pharmacodynamics and pharmacokinetics of phenylbutazone in calves., J. Vet. Pharmacol. Ther.
    Beretta et al., 2005, COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis., Pharmacol. Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Takada et al., 2004, Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation., Oncogene
    Morton et al., 2005, Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis., Res. Vet. Sci.
    Zitova et al., 2010, Analysis of activity and inhibition of oxygen-dependent enzymes by optical respirometry on the LightCycler system., Anal. Biochem.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Buttar D et al., 2010, A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions., Bioorg Med Chem
  • PHENYLBUTAZONE   PTGIS

    Interaction Score: 36.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    3517382 6434940 3917545 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • PHENYLBUTAZONE   FPR1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENYLBUTAZONE   PTGS2

    Interaction Score: 0.5

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Cyclooxygenase inhibitor

    PMIDs:
    12213119 15939622 11752352 15489888


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PHENYLBUTAZONE   ALB

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20869876


    Sources:
    DTC

  • PHENYLBUTAZONE   PTGS1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclooxygenase inhibitor
    Direct Interaction yes

    PMIDs:
    15939622 15563928 19849999


    Sources:
    ChemblInteractions

  • PHENYLBUTAZONE   NR1I2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PHENYLBUTAZONE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PHENYLBUTAZONE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PHENYLBUTAZONE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PHENYLBUTAZONE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PHENYLBUTAZONE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PHENYLBUTAZONE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PHENYLBUTAZONE

    • Version: 01-August-2011

    Alternate Names:
    PHENYLBUTAZONE Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class anti-inflammatory agents, non-steroidal

    Publications:

  • TdgClinicalTrial: PHENYLBUTAZONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications NSAID
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • DTC: PHENYLBUTAZONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL101 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Buttar D et al., 2010, A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions., Bioorg Med Chem

  • TTD: Phenylbutazone

    • Version: 2020.06.01

    Alternate Names:
    D07VHR TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL101

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL101

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: phenylbutazone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21