DGIdb - PHENYLPROPANOLAMINE Drug Record

PHENYLPROPANOLAMINE chembl:CHEMBL61006

Alternate Names:

PHENYLPROPANOLAMINE

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Nasal Decongestants
Drug Indications	Appetite Depressants
Year of Approval	approved before 1982
Drug Class	nasal decongestants
Drug Class	appetite depressants

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Publications:

Moya-Huff et al., 1987, Adrenergic receptor subtype activation by (+)-, (-)- and (+/-)-norephedrine in the pithed rat., J. Pharm. Pharmacol.
Buckner et al., 2002, ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes., Eur. J. Pharmacol.
Altenbach et al., 2004, Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist., J. Med. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Wellman et al., Effects of the alpha 1a-adrenoceptor antagonist RS-17053 on phenylpropanolamine-induced anorexia in rats., Pharmacol. Biochem. Behav.
Flavahan, 2005, Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors., J. Pharmacol. Exp. Ther.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

PHENYLPROPANOLAMINE ADRA1A

Interaction Score: 2.49

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2881994 12163120 15163201 17016423 9164583

Sources:
TdgClinicalTrial TEND
PHENYLPROPANOLAMINE ADRA2A

Interaction Score: 2.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15608085 17016423 17139284

Sources:
TdgClinicalTrial TEND

TdgClinicalTrial: PHENYLPROPANOLAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Appetite Depressants

Drug Indications Nasal Decongestants

Drug Class small molecule

Publications:
TEND: PHENYLPROPANOLAMINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class appetite depressants

Drug Class nasal decongestants

Year of Approval approved before 1982

Publications:
ChemblDrugs: chembl:CHEMBL61006
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

PHENYLPROPANOLAMINE Drug Record

PHENYLPROPANOLAMINE chembl:CHEMBL61006

Alternate Names:

Drug Info:

Publications:

PHENYLPROPANOLAMINE ADRA1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2881994 12163120 15163201 17016423 9164583

Sources: TdgClinicalTrial TEND

PHENYLPROPANOLAMINE ADRA2A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15608085 17016423 17139284

Sources: TdgClinicalTrial TEND

TdgClinicalTrial: PHENYLPROPANOLAMINE

Alternate Names:

Drug Info: Drug Indications Appetite Depressants Drug Indications Nasal Decongestants Drug Class small molecule

Publications:

TEND: PHENYLPROPANOLAMINE

Alternate Names:

Drug Info: Drug Class appetite depressants Drug Class nasal decongestants Year of Approval approved before 1982

Publications:

ChemblDrugs: chembl:CHEMBL61006

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2881994 12163120 15163201 17016423 9164583

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15608085 17016423 17139284

Sources:
TdgClinicalTrial TEND

Drug Info:

Drug Indications Appetite Depressants

Drug Indications Nasal Decongestants

Drug Class small molecule

Drug Info:

Drug Class appetite depressants

Drug Class nasal decongestants

Year of Approval approved before 1982