DGIdb - PITAVASTATIN Drug Record

PITAVASTATIN chembl:CHEMBL1201753 Approved

Alternate Names:

PITAVASTATIN
ITAVASTATIN
NK 104
NK-104
NKS104
rxcui:861634
chembl:CHEMBL1201753
drugbank:08860
pubchem.compound:5282452
chemidplus:147511-69-1

Drug Info:

FDA Approval	approved
Drug Class	small molecule
Drug Indications	anticholesterolaemic agent
Year of Approval	2009
Drug Class	anticholesteremic agents

(0 More Sources)

Publications:

Sai K et al., 2016, A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients., Drug Metab Pharmacokinet
Oh ES et al., 2013, Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans., Drug Metab Pharmacokinet
Wen J et al., 2010, OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers., J Clin Pharm Ther
Hirano M et al., 2004, Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans., J Pharmacol Exp Ther
Hirano M et al., 2006, Drug-drug interaction between pitavastatin and various drugs via OATP1B1., Drug Metab Dispos
Morgan et al., 2012, Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects., J. Cardiovasc. Pharmacol.
Hoy SM, 2017, Pitavastatin: A Review in Hypercholesterolemia., Am J Cardiovasc Drugs

PITAVASTATIN HMGCR

Interaction Score: 3.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name pitavastatin , NK-104,Livalo

PMIDs:
22472908 28130659

Sources:
TdgClinicalTrial TEND
PITAVASTATIN SLCO1B1

Interaction Score: 1.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007012 20175818 15159445 16595711

Sources:
PharmGKB
PITAVASTATIN HLA-DRB1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27839692

Sources:
PharmGKB
PITAVASTATIN ABCC2

Interaction Score: 0.6

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007012

Sources:
PharmGKB

TEND: PITAVASTATIN
- Version: 01-August-2011
Alternate Names:

PITAVASTATIN Primary Drug Name

Drug Info:

Drug Class anticholesteremic agents

Year of Approval 2009

Publications:
TdgClinicalTrial: PITAVASTATIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anticholesterolaemic agent

Drug Class small molecule

FDA Approval approved

Publications:

PharmGKB: pitavastatin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Hirano M et al., 2004, Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans., J Pharmacol Exp Ther

Hirano M et al., 2006, Drug-drug interaction between pitavastatin and various drugs via OATP1B1., Drug Metab Dispos

Wen J et al., 2010, OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers., J Clin Pharm Ther

ChemblDrugs: chembl:CHEMBL1201753
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	pitavastatin , NK-104,Livalo

PITAVASTATIN Drug Record

PITAVASTATIN chembl:CHEMBL1201753 Approved

Alternate Names:

Drug Info:

Publications:

PITAVASTATIN HMGCR

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name pitavastatin , NK-104,Livalo

PMIDs: 22472908 28130659

Sources: TdgClinicalTrial TEND

PITAVASTATIN SLCO1B1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007012 20175818 15159445 16595711

Sources: PharmGKB

PITAVASTATIN HLA-DRB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27839692

Sources: PharmGKB

PITAVASTATIN ABCC2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007012

Sources: PharmGKB

TEND: PITAVASTATIN

Alternate Names: PITAVASTATIN Primary Drug Name

Drug Info: Drug Class anticholesteremic agents Year of Approval 2009

Publications:

TdgClinicalTrial: PITAVASTATIN

Alternate Names:

Drug Info: Drug Indications anticholesterolaemic agent Drug Class small molecule FDA Approval approved

Publications:

PharmGKB: pitavastatin

Alternate Names:

Drug Info:

ChemblDrugs: chembl:CHEMBL1201753

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name pitavastatin , NK-104,Livalo

PMIDs:
22472908 28130659

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
23007012 20175818 15159445 16595711

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27839692

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23007012

Sources:
PharmGKB

Alternate Names:

PITAVASTATIN Primary Drug Name

Drug Info:

Drug Class anticholesteremic agents

Year of Approval 2009

Drug Info:

Drug Indications anticholesterolaemic agent

Drug Class small molecule

FDA Approval approved