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PITOLISANT Drug Record

  • Summary
  • Interactions
  • Claims
  • PITOLISANT chembl:CHEMBL462605 Approved

    Alternate Names:

    WAKIX
    BF2.649
    BF-2649
    TIPROLISANT
    WAKIX, EUROPE
    PITOLISANT
    HBS-101
    BF-2.649

    Drug Info:

    (1 More Sources)

    Publications:

    Inocente C et al., 2012, Pitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepiness., Clin Neuropharmacol
    Khanfar MA et al., 2016, Multiple Targeting Approaches on Histamine H3 Receptor Antagonists., Front Neurosci
    Schwartz JC, 2011, The histamine H3 receptor: from discovery to clinical trials with pitolisant., Br J Pharmacol
  • PITOLISANT   HRH3

    Interaction Score: 8.14

    Interaction Types & Directionality:
    inverse agonist (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histamine H3 receptor inverse agonist

    PMIDs:
    22356925 27303254 21615387


    Sources:
    ChemblInteractions TTD

  • PITOLISANT   CYP2D6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TTD: Pitolisant

    • Version: 2020.06.01

    Alternate Names:
    D01UUD TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL462605

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL462605

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: pitolisant

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Pitolisant

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21