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POZIOTINIB Drug Record

  • Summary
  • Interactions
  • Claims
  • POZIOTINIB chembl:CHEMBL3545154 Antineoplastic

    Alternate Names:

    HM-781-36B
    NOV-120101
    HM 781-36B
    POZIOTINIB
    NOV120101
    HM781-36B
    drugbank:12114
    chemidplus:1092364-38-9
    pubchem.compound:25127713
    chembl:CHEMBL3545154

    Drug Info:

    (1 More Sources)

    Publications:

    Nam et al., 2011, Antitumor activity of HM781-36B, an irreversible Pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer., Cancer Lett.
  • POZIOTINIB   ERBB3

    Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Epidermal growth factor receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions MyCancerGenomeClinicalTrial

  • POZIOTINIB   ERBB4

    Interaction Score: 0.75

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Epidermal growth factor receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions MyCancerGenomeClinicalTrial

  • POZIOTINIB   ERBB2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Epidermal growth factor receptor inhibitor
    Direct Interaction yes
    Indication/Tumor Type stomach cancer

    PMIDs:
    21306821


    Sources:
    JAX-CKB ChemblInteractions MyCancerGenomeClinicalTrial

  • POZIOTINIB   EGFR

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Indication/Tumor Type lung adenocarcinoma
    Response Type sensitive
    Approval Status Phase II

    PMIDs:
    None found


    Sources:
    JAX-CKB ChemblInteractions MyCancerGenomeClinicalTrial OncoKB

  • POZIOTINIB   KRAS

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type stomach cancer
    Response Type resistant
    Approval Status Preclinical

    PMIDs:
    21306821


    Sources:
    JAX-CKB

  • JAX-CKB: poziotinib

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Nam et al., 2011, Antitumor activity of HM781-36B, an irreversible Pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer., Cancer Lett.

  • MyCancerGenomeClinicalTrial: POZIOTINIB

    • Version: 30-February-2014

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL3545154

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL3545154

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • OncoKB: Poziotinib

    • Version: 23-July-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21