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PRACTOLOL Drug Record

  • Summary
  • Interactions
  • Claims
  • PRACTOLOL chembl:CHEMBL6995 Approved

    Alternate Names:

    [3-(4-ACETYLAMINO-PHENOXY)-2-HYDROXY-PROPYL]-ISOPROPYL-AMMONIUM
    PRACTOLOL
    ICI-50172
    AY-21011
    ERALDIN
    (+-)-PRACTOLOL
    TOCRIS-0831
    PRACTOLOLUM
    4'-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)ACETANILIDE
    N-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ACETAMIDE
    1-(4-ACETAMIDOPHENOXY)-3-ISOPROPYLAMINO-2-PROPANOL
    pubchem.compound:4883
    chemidplus:6673-35-4
    chembl:CHEMBL6995
    drugbank:01297
    rxcui:8620

    Drug Info:

    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Anti-Arrhythmia Agents
    Year of Approval not approved by the fda
    Drug Class anti-arrhythmia agents
    (1 More Sources)

    Publications:

    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Saarnivaara et al., 1984, Effects of practolol and metoprolol on QT interval, heart rate and arterial pressure during induction of anaesthesia., Acta Anaesthesiol Scand
    Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
    Keyriläinen et al., 1978, A comparative study of three beta 1-adrenoreceptor blocking drugs with different degree of intrinsic stimulating activity (metoprolol, practolol and H 87/07) in patients with angina pectoris., Ann. Clin. Res.
    Buxton et al., 1985, Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat., Circ. Res.
  • PRACTOLOL   ADRB1

    Interaction Score: 7.45

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2903243 11752352 6524278 2871880 30388 2857116


    Sources:
    DTC TdgClinicalTrial TEND TTD

  • TdgClinicalTrial: PRACTOLOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-Arrhythmia Agents
    Drug Class small molecule
    FDA Approval not approved by the FDA

    Publications:

  • TEND: PRACTOLOL

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class anti-arrhythmia agents
    Year of Approval not approved by the fda

    Publications:

  • DTC: PRACTOLOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL6995 ChEMBL Drug ID

    Drug Info:

    Publications:
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

  • TTD: Practolol

    • Version: 2020.06.01

    Alternate Names:
    D0KD1U TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL6995

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21