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PRAZOSIN Drug Record

  • Summary
  • Interactions
  • Claims
  • PRAZOSIN chembl:CHEMBL2 Approved

    Alternate Names:

    CP-12299
    CP-122991
    PRAZOSIN
    2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETHOXYQUINAZOLINE
    MINIPRESS®
    HYPOVASE®
    PRAZOSINUM
    1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE
    PRAZOSINE
    PRAZOSINA
    CP-12299-1
    rxcui:8629
    chembl:CHEMBL2
    chemidplus:19216-56-9
    pubchem.compound:4893
    drugbank:00457

    Drug Info:

    FDA Approval 1976
    Drug Class small molecule
    Drug Indications antispasmodics
    Drug Indications Antihypertensive Agents
    Year of Approval 1976
    Drug Class antispasmodics
    Drug Class antihypertensive agents
    (2 More Sources)

    Publications:

    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
    Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
    Sharpe et al., 2003, Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA., J. Biol. Chem.
    Al-Damluji et al., 2001, alpha(1B) adrenergic receptors in gonadotrophin-releasing hormone neurones: relation to Transport-P., Br. J. Pharmacol.
    Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
    Morris et al., 2004, Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent., Mol. Pharmacol.
    Suzuki et al., 2000, Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs., Eur. J. Pharmacol.
    Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
    Chang et al., 2003, Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro., J. Pharm. Pharmacol.
    Zacharia et al., 2004, Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries., Br. J. Pharmacol.
    Nagaoka et al., 2008, Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding., J. Pharmacol. Sci.
    Yamamoto et al., 2001, alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta., Br. J. Pharmacol.
    Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock
    Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos
  • PRAZOSIN   ADRA1D

    Interaction Score: 1.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18187928 7855217 11682453


    Sources:
    TdgClinicalTrial TEND

  • PRAZOSIN   ADRA1B

    Interaction Score: 1.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7855217 8925876 12270758 11752352 7691623 12824165 11156594


    Sources:
    TdgClinicalTrial TEND

  • PRAZOSIN   ADRA1A

    Interaction Score: 0.79

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7855217 15258254 10771044 17658513 12841945 14980979 8925876 7691623


    Sources:
    TdgClinicalTrial TEND

  • PRAZOSIN   NOS1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9322222


    Sources:
    NCI

  • PRAZOSIN   MAPK8

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12095132


    Sources:
    NCI

  • PRAZOSIN   ABCG2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23073734


    Sources:
    DTC

  • PRAZOSIN   HSD17B10

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PRAZOSIN   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PRAZOSIN   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PRAZOSIN

    • Version: 01-August-2011

    Alternate Names:
    PRAZOSIN Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Drug Class antispasmodics
    Year of Approval 1976

    Publications:

  • TdgClinicalTrial: PRAZOSIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications antispasmodics
    Drug Class small molecule

    Publications:

  • DTC: PRAZOSIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL2 ChEMBL Drug ID

    Drug Info:

    Publications:
    Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

  • NCI: PRAZOSIN

    • Version: 14-September-2017

    Alternate Names:
    C767 NCI drug code

    Drug Info:

    Publications:
    Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
    Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock

  • TTD: Prazosin

    • Version: 2020.06.01

    Alternate Names:
    D0WV3U TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21