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PREDNISOLONE Drug Record

  • Summary
  • Interactions
  • Claims
  • PREDNISOLONE chembl:CHEMBL131 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    NSC-9900
    CORTALONE
    DELTACORTRIL
    DELTALONE
    HYDELTRA
    PRECORTISYL FTE
    FERNISOLONE-P
    PRED-G
    METICORTELONE
    SCHERIPROCT
    DELTA-CORTEF
    DEKOTIL
    PREDNISOLONE
    POLY-PRED
    DESOWEN
    METI-DERM
    PRECORTISYL
    NEO-DELTA-CORTEF
    STERANE
    SERVISONE
    HYDELTRA-TBA
    NSC-9120
    PEVANTI
    VERDESO
    TRIDESILON
    PRELONE
    DILACORT
    DELTA-DEHYDROCORTISOL
    3,20-DIOXO-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE
    METACORTANDRALONE
    1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL
    PREDNISOLONA
    DELTA(1)-DEHYDROCORTISOL
    (11BETA)-11,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
    DELTA(1)-HYDROCORTISONE
    PEDIAPRED®
    1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
    PRDL
    HYDRORETROCORTINE
    IMS904
    DELTA(1)-DEHYDROHYDROCORTISONE
    ORAPRED®
    DELTA-HYDROCORTISONE
    PREDNISOLONUM
    DELTA-DEHYDROHYDROCORTISONE
    DELTA.1-CORTISOL
    drugbank:00860
    chembl:CHEMBL131
    chemidplus:50-24-8
    pubchem.compound:5755
    rxcui:8638

    Drug Info:

    Drug Class Small Molecule
    FDA Approval approved
    Drug Indications antiinflammatory agent,corticosteroid
    Drug Class glucocorticoids
    Drug Class anti-inflammatory agents
    Year of Approval approved before 1982
    (5 More Sources)

    Publications:

    Dewson et al., 2003, Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells., Oncogene
    Cario et al., 1999, A microdeletion syndrome due to a 3-Mb deletion on 19q13.2--Diamond-Blackfan anemia associated with macrocephaly, hypotonia, and psychomotor retardation., Clin. Genet.
    Fujita et al., 2007, Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil., Intern. Med.
    Furugen et al., 2008, Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone., Respir. Res.
    Gregers J et al., 2015, Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia., Pharmacogenomics J
    Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics
    Hodsman et al., 1991, Differential effects of inhaled budesonide and oral prednisolone on serum osteocalcin., J. Clin. Endocrinol. Metab.
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Usui et al., 2003, Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor., Biol. Pharm. Bull.
    Yamada et al., 1996, Dissociation between serum interleukin-6 rise and other parameters of disease activity in subacute thyroiditis during treatment with corticosteroid., J. Clin. Endocrinol. Metab.
    Yamamoto et al., 1987, Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis., Clin. Endocrinol. (Oxf)
    Boudinot et al., 1986, Receptor-mediated pharmacodynamics of prednisolone in the rat., J Pharmacokinet Biopharm
    Ikonomidis et al., 2009, Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis., Heart
    Ueda, 1990, Effect of corticosteroids on some hemostatic parameters in children with minimal change nephrotic syndrome., Nephron
    Pikman et al., 2017, Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia., Clin. Cancer Res.
    Izawa et al., 1982, Dynamics of glucocorticoid receptor and induction of tyrosine aminotransferase in rat liver., Endocrinol. Jpn.
    Tuncer et al., 1994, The effect of high-dose methylprednisolone combined chemotherapy on CD34-positive cells in acute lymphoblastic leukemia., Hematol Pathol
    Gutierrez-Camino A et al., 2017, PNPLA3 rs738409 and Hepatotoxicity in Children With B-cell Acute Lymphoblastic Leukemia: A Validation Study in a Spanish Cohort., Clin Pharmacol Ther
    Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.
    Nozawa et al., 1984, [Modulation of alkaline phosphatase by butyrate and prednisolone in uterine cervical cancer cell line (SKG-III)]., Nippon Sanka Fujinka Gakkai Zasshi
    Nayak et al., 1990, Serum apolipoproteins A and B, lecithin: cholesterol acyl transferase activities and urinary cholesterol levels in nephrotic syndrome patients before and during steroid treatment., Nephron
  • PREDNISOLONE   ALPP

    Interaction Score: 2.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6699450


    Sources:
    NCI

  • PREDNISOLONE   DSE

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PREDNISOLONE   LCAT

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2314540


    Sources:
    NCI

  • PREDNISOLONE   CD34

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7532164


    Sources:
    NCI

  • PREDNISOLONE   TSPYL1

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PREDNISOLONE   LOH19CR1

    Interaction Score: 0.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10450869


    Sources:
    NCI

  • PREDNISOLONE   PNPLA3

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28744905


    Sources:
    PharmGKB

  • PREDNISOLONE   TAT

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6127207


    Sources:
    NCI

  • PREDNISOLONE   HMGB1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18447956


    Sources:
    NCI

  • PREDNISOLONE   TG

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8636270 3427792


    Sources:
    NCI

  • PREDNISOLONE   NOTCH1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Prednisolone
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • PREDNISOLONE   FCGR3B

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17329922


    Sources:
    NCI

  • PREDNISOLONE   RB1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Prednisolone
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • PREDNISOLONE   BGLAP

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1997509


    Sources:
    NCI

  • PREDNISOLONE   FCGR3A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17329922


    Sources:
    NCI

  • PREDNISOLONE   PLG

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2079995


    Sources:
    NCI

  • PREDNISOLONE   ANXA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • PREDNISOLONE   NR3C1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes
    Trial Name CRx-102, prednisolone plus dipyridamole ,Synavive

    PMIDs:
    2879901 19482847


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PREDNISOLONE   BAX

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12730678


    Sources:
    NCI

  • PREDNISOLONE   G6PD

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16324786


    Sources:
    NCI

  • PREDNISOLONE   CYP3A5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12673034


    Sources:
    NCI

  • PREDNISOLONE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25582575 14583680


    Sources:
    PharmGKB

  • PREDNISOLONE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • PREDNISOLONE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PREDNISOLONE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PREDNISOLONE

    • Version: 01-August-2011

    Alternate Names:
    PREDNISOLONE Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class anti-inflammatory agents
    Drug Class glucocorticoids

    Publications:

  • TdgClinicalTrial: PREDNISOLONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiinflammatory agent,corticosteroid
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: PREDNISOLONE

    • Version: 14-September-2017

    Alternate Names:
    C769 NCI drug code

    Drug Info:

    Publications:
    Dewson et al., 2003, Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells., Oncogene
    Cario et al., 1999, A microdeletion syndrome due to a 3-Mb deletion on 19q13.2--Diamond-Blackfan anemia associated with macrocephaly, hypotonia, and psychomotor retardation., Clin. Genet.
    Usui et al., 2003, Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor., Biol. Pharm. Bull.

  • JAX-CKB: Prednisolone

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Pikman et al., 2017, Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia., Clin. Cancer Res.

  • PharmGKB: prednisolone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics
    Gregers J et al., 2015, Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia., Pharmacogenomics J

  • TTD: Prednisolone

    • Version: 2020.06.01

    Alternate Names:
    D0D1SG TTD Drug ID

    Drug Info:

    Publications:

  • DTC: PREDNISOLONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL131 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL131

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL131

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21