PRIMIDONE Drug Record

  • PRIMIDONE   GRIK2

    Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • PRIMIDONE   GABRA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11264449 14579514 10209232 11752352 10487207 17016423 17139284 24385718


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PRIMIDONE   CHRNA4

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • PRIMIDONE   GRIA2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • PRIMIDONE   CHRNA7

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • PRIMIDONE   TRPM3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PRIMIDONE   GABRA6

    Interaction Score: 0.13

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    10209232 11264449


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PRIMIDONE   GABRA5

    Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    10209232 11264449


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PRIMIDONE   GABRA3

    Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    10209232 11264449


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PRIMIDONE   GABRA2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    10209232 11264449


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PRIMIDONE   GABRA4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Direct Interaction yes

    PMIDs:
    10209232


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PRIMIDONE   SCN7A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRQ

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN8A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN11A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN3A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRE

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRP

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRB3

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRG1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN4A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRG2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN9A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   GABRG3

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN10A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN5A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PRIMIDONE

    • Version: 01-August-2011

    Alternate Names:
    PRIMIDONE Primary Drug Name

    Drug Info:
    Year of Approval 1954
    Drug Class anticonvulsants

    Publications:

  • TdgClinicalTrial: PRIMIDONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anticonvulsants
    Drug Class small molecule
    FDA Approval 1954

    Publications:

  • TTD: Primidone

    • Version: 2020.06.01

    Alternate Names:
    D0U5RT TTD Drug ID

    Drug Info:

    Publications:

  • DTC: PRIMIDONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL856 ChEMBL Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 178102002

    • Version: 29-September-2020

    Alternate Names:
    PRIMIDONE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL856

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL856

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications: