DGIdb - PROBENECID Drug Record

PROBENECID chembl:CHEMBL897 Approved

Alternate Names:

PROBAMPICIN
HC 5006
BENEMID
PROBECID
NSC-18786
PROBALAN
PROBENECID
BENURYL
P-(DIPROPYLSULFAMOYL)BENZOIC ACID
PROBENECIDE
4-(N,N-DIPROPYLSULFAMOYL)BENZOESAEURE
4-(DI-N-PROPYLSULFAMOYL)BENZOESAEURE
PROBENECID ACID
PROBENECIDA
PROBENECIDUM
PROBALAN®
4-((DIPROPYLAMINO)SULFONYL)BENZOIC ACID
drugbank:01032
chembl:CHEMBL897
pubchem.compound:4911
rxcui:8698
chemidplus:57-66-9

Drug Info:

Drug Class	uricosuric agents
Year of Approval	approved before 1982
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Uricosuric Agents

(4 More Sources)

Publications:

Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.
Sweet et al., 2003, Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient., Am. J. Physiol. Renal Physiol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Jung et al., 2001, Characterization of ochratoxin A transport by human organic anion transporters., Life Sci.
Takeda et al., 2001, Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters., Eur. J. Pharmacol.
Kusuhara et al., 1999, Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain., J. Biol. Chem.
Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos
Enomoto et al., 2002, Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors., J. Pharmacol. Exp. Ther.
Hashimoto et al., 2004, Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters., Drug Metab. Dispos.
Babu et al., 2002, Role of human organic anion transporter 4 in the transport of ochratoxin A., Biochim. Biophys. Acta
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Gollapudi et al., 1997, Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells., Cancer Chemother. Pharmacol.

PROBENECID SLC22A11

Interaction Score: 20.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Solute carrier family 22 member 11 inhibitor

PMIDs:
12130730 12023506 15377641 12063169

Sources:
TdgClinicalTrial ChemblInteractions TEND
PROBENECID SLC22A8

Interaction Score: 8.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12130730 12488248 10592235 11669456 11426832 10224140 23344796

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
PROBENECID SLC22A6

Interaction Score: 6.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 6 inhibitor

Direct Interaction yes

PMIDs:
11426832 12130730 11752352 15377641 11669456

Sources:
ChemblInteractions
PROBENECID ABCC1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9182837

Sources:
NCI
PROBENECID G6PD

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
PROBENECID ABCB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9182837

Sources:
NCI
PROBENECID AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PROBENECID
- Version: 01-August-2011
Alternate Names:

PROBENECID Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class uricosuric agents

Publications:
TdgClinicalTrial: PROBENECID
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Uricosuric Agents

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
DTC: PROBENECID
- Version: 02-September-2020
Alternate Names:

CHEMBL897 ChEMBL Drug ID

Drug Info:

Publications:

Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos

NCI: PROBENECID

Version: 14-September-2017

Alternate Names:

C772 NCI drug code

Drug Info:

Publications:

Gollapudi et al., 1997, Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells., Cancer Chemother. Pharmacol.

TTD: Probenecid
- Version: 2020.06.01
Alternate Names:

D0L7FM TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL897
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Probenecid
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL897
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Solute carrier family 22 member 11 inhibitor

Mechanism of Interaction	Solute carrier family 22 member 8 inhibitor
Direct Interaction	yes
Trial Name	-

Mechanism of Interaction	Solute carrier family 22 member 6 inhibitor
Direct Interaction	yes

PROBENECID Drug Record

PROBENECID chembl:CHEMBL897 Approved

Alternate Names:

Drug Info:

Publications:

PROBENECID SLC22A11

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Solute carrier family 22 member 11 inhibitor

PMIDs: 12130730 12023506 15377641 12063169

Sources: TdgClinicalTrial ChemblInteractions TEND

PROBENECID SLC22A8

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Solute carrier family 22 member 8 inhibitor Direct Interaction yes Trial Name -

PMIDs: 12130730 12488248 10592235 11669456 11426832 10224140 23344796

Sources: DTC TdgClinicalTrial ChemblInteractions TEND TTD

PROBENECID SLC22A6

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Solute carrier family 22 member 6 inhibitor Direct Interaction yes

PMIDs: 11426832 12130730 11752352 15377641 11669456

Sources: ChemblInteractions

PROBENECID ABCC1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9182837

Sources: NCI

PROBENECID G6PD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

PROBENECID ABCB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9182837

Sources: NCI

PROBENECID AR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PROBENECID

Alternate Names: PROBENECID Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class uricosuric agents

Publications:

TdgClinicalTrial: PROBENECID

Alternate Names:

Drug Info: Drug Indications Uricosuric Agents Drug Class small molecule FDA Approval Approved before 1982

Publications:

DTC: PROBENECID

Alternate Names: CHEMBL897 ChEMBL Drug ID

Drug Info:

Publications: Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos

NCI: PROBENECID

Alternate Names: C772 NCI drug code

Drug Info:

Publications: Gollapudi et al., 1997, Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells., Cancer Chemother. Pharmacol.

TTD: Probenecid

Alternate Names: D0L7FM TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL897

Alternate Names:

Drug Info:

Publications:

FDA: Probenecid

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL897

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Solute carrier family 22 member 11 inhibitor

PMIDs:
12130730 12023506 15377641 12063169

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12130730 12488248 10592235 11669456 11426832 10224140 23344796

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 6 inhibitor

Direct Interaction yes

PMIDs:
11426832 12130730 11752352 15377641 11669456

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
9182837

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
9182837

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PROBENECID Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class uricosuric agents

Drug Info:

Drug Indications Uricosuric Agents

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

CHEMBL897 ChEMBL Drug ID

Publications:

Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos

Alternate Names:

C772 NCI drug code

Publications:

Gollapudi et al., 1997, Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells., Cancer Chemother. Pharmacol.

Alternate Names:

D0L7FM TTD Drug ID