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PROBENECID Drug Record

  • Summary
  • Interactions
  • Claims
  • PROBENECID chembl:CHEMBL897 Approved

    Alternate Names:

    PROBAMPICIN
    HC 5006
    BENEMID
    PROBECID
    NSC-18786
    PROBALAN
    PROBENECID
    BENURYL
    P-(DIPROPYLSULFAMOYL)BENZOIC ACID
    PROBENECIDE
    4-(N,N-DIPROPYLSULFAMOYL)BENZOESAEURE
    4-(DI-N-PROPYLSULFAMOYL)BENZOESAEURE
    PROBENECID ACID
    PROBENECIDA
    PROBENECIDUM
    PROBALAN®
    4-((DIPROPYLAMINO)SULFONYL)BENZOIC ACID
    drugbank:01032
    chembl:CHEMBL897
    pubchem.compound:4911
    rxcui:8698
    chemidplus:57-66-9

    Drug Info:

    Drug Class uricosuric agents
    Year of Approval approved before 1982
    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Uricosuric Agents
    (4 More Sources)

    Publications:

    Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.
    Sweet et al., 2003, Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient., Am. J. Physiol. Renal Physiol.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Jung et al., 2001, Characterization of ochratoxin A transport by human organic anion transporters., Life Sci.
    Takeda et al., 2001, Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters., Eur. J. Pharmacol.
    Kusuhara et al., 1999, Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain., J. Biol. Chem.
    Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos
    Enomoto et al., 2002, Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors., J. Pharmacol. Exp. Ther.
    Hashimoto et al., 2004, Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters., Drug Metab. Dispos.
    Babu et al., 2002, Role of human organic anion transporter 4 in the transport of ochratoxin A., Biochim. Biophys. Acta
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Gollapudi et al., 1997, Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells., Cancer Chemother. Pharmacol.
  • PROBENECID   SLC22A11

    Interaction Score: 20.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Solute carrier family 22 member 11 inhibitor

    PMIDs:
    12130730 12023506 15377641 12063169


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PROBENECID   SLC22A8

    Interaction Score: 8.83

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Solute carrier family 22 member 8 inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    12130730 12488248 10592235 11669456 11426832 10224140 23344796


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • PROBENECID   SLC22A6

    Interaction Score: 6.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Solute carrier family 22 member 6 inhibitor
    Direct Interaction yes

    PMIDs:
    11426832 12130730 11752352 15377641 11669456


    Sources:
    ChemblInteractions

  • PROBENECID   ABCC1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9182837


    Sources:
    NCI

  • PROBENECID   G6PD

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • PROBENECID   ABCB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9182837


    Sources:
    NCI

  • PROBENECID   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PROBENECID

    • Version: 01-August-2011

    Alternate Names:
    PROBENECID Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class uricosuric agents

    Publications:

  • TdgClinicalTrial: PROBENECID

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Uricosuric Agents
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • DTC: PROBENECID

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL897 ChEMBL Drug ID

    Drug Info:

    Publications:
    Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos

  • NCI: PROBENECID

    • Version: 14-September-2017

    Alternate Names:
    C772 NCI drug code

    Drug Info:

    Publications:
    Gollapudi et al., 1997, Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells., Cancer Chemother. Pharmacol.

  • TTD: Probenecid

    • Version: 2020.06.01

    Alternate Names:
    D0L7FM TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL897

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Probenecid

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL897

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21