DGIdb - PROMETHAZINE Drug Record

PROMETHAZINE chembl:CHEMBL643 Approved

Alternate Names:

REMSED
PROMETHACON
ZIPAN-25
PROMETHAZINE
PROMETHEGAN
PHENERGAN
ZIPAN-50
NSC-30321
RP-3277
PROAZAMINE
10-(2-DIMETHYLAMINOPROPYL)PHENOTHIAZINE
SOMINEX®
PROMETAZINA
10-[2-(DIMETHYLAMINO)PROPYL]PHENOTHIAZINE
N-(2'-DIMETHYLAMINO-2'-METHYL)ETHYLPHENOTHIAZINE
PHENERGAN®
N,N,Α-TRIMETHYL-10H-PHENOTHIAZINE-10-ETHANAMINE
N,N,ALPHA-TRIMETHYL-10H-PHENOTHIAZINE-10-ETHANAMINE
PROMETHAZINUM
(2-DIMETHYLAMINO-2-METHYL)ETHYL-N-DIBENZOPARATHIAZINE
chemidplus:60-87-7
drugbank:01069
pubchem.compound:4927
chembl:CHEMBL643
rxcui:8745

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Anti-allergic Agents
Drug Indications	Anti-anxiety agents
Drug Indications	Hypnotics and Sedatives
Drug Class	anti-anxiety agents
Drug Class	anti-allergic agents
Year of Approval	approved before 1982
Drug Class	hypnotics and sedatives

(3 More Sources)

Publications:

Miller et al., 1989, Factors in snake venoms that increase capillary permeability., J. Pharm. Pharmacol.
Claro et al., 1986, Phosphoinositide hydrolysis mediated by histamine H1-receptors in rat brain cortex., Eur. J. Pharmacol.
Suzuki et al., 2003, Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol., Ther Drug Monit
Smith et al., 1993, Histamine enhances the depolarizing afterpotential of immunohistochemically identified vasopressin neurons in the rat supraoptic nucleus via H1-receptor activation., Neuroscience
Paton et al., Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines)., Clin Pharmacokinet
Ikeda et al., 1997, Histamine-induced calcium released from cultured human mucosal microvascular endothelial cells from nasal inferior turbinate., Acta Otolaryngol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Taylor et al., 1985, Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone., Xenobiotica
Golembiewski et al., 2002, A systematic approach to the management of postoperative nausea and vomiting., J. Perianesth. Nurs.
Pontiroli et al., 1981, The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress., J. Clin. Endocrinol. Metab.
Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract

PROMETHAZINE CHRM4

Interaction Score: 0.56

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND
PROMETHAZINE CYP1A1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4024659

Sources:
NCI
PROMETHAZINE HRH1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2576052 3011460 12657913 8098142 2866055 9442829 11752352

Sources:
TdgClinicalTrial TEND TTD
PROMETHAZINE CHRM5

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND
PROMETHAZINE PRL

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7228996

Sources:
NCI
PROMETHAZINE CHRM2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND
PROMETHAZINE CHRM3

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND
PROMETHAZINE CHRM1

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND
PROMETHAZINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROMETHAZINE CBX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROMETHAZINE HTT

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROMETHAZINE ATXN2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROMETHAZINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4024659

Sources:
NCI
PROMETHAZINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17986163

Sources:
PharmGKB
PROMETHAZINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: PROMETHAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Indications Anti-anxiety agents

Drug Indications Anti-allergic Agents

Publications:
TEND: PROMETHAZINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval approved before 1982

Drug Class anti-allergic agents

Publications:

NCI: PROMETHAZINE

Version: 14-September-2017

Alternate Names:

C779 NCI drug code

Drug Info:

Publications:

Pontiroli et al., 1981, The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress., J. Clin. Endocrinol. Metab.

Taylor et al., 1985, Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone., Xenobiotica

PharmGKB: promethazine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract
DTC: PROMETHAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL643 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Promethazine
- Version: 2020.06.01
Alternate Names:

D0T2XU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL643
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

PROMETHAZINE Drug Record

PROMETHAZINE chembl:CHEMBL643 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 12476402

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4024659

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2576052 3011460 12657913 8098142 2866055 9442829 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12476402

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7228996

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12476402

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12476402

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12476402

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4024659

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17986163

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: PROMETHAZINE

Alternate Names:

Drug Info: Drug Indications Hypnotics and Sedatives Drug Indications Anti-anxiety agents Drug Indications Anti-allergic Agents

Publications:

TEND: PROMETHAZINE

Alternate Names:

Drug Info: Drug Class hypnotics and sedatives Year of Approval approved before 1982 Drug Class anti-allergic agents

Publications:

NCI: PROMETHAZINE

Alternate Names: C779 NCI drug code

Drug Info:

PharmGKB: promethazine

Alternate Names:

Drug Info:

Publications: Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
4024659

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2576052 3011460 12657913 8098142 2866055 9442829 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
7228996

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
4024659

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17986163

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Indications Anti-anxiety agents

Drug Indications Anti-allergic Agents

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval approved before 1982

Drug Class anti-allergic agents

Alternate Names:

C779 NCI drug code

Publications:

Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract

Alternate Names:

CHEMBL643 ChEMBL Drug ID

Alternate Names:

D0T2XU TTD Drug ID