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PROPAFENONE Drug Record

  • Summary
  • Interactions
  • Claims
  • PROPAFENONE chembl:CHEMBL631 Approved

    Alternate Names:

    GNF-PF-4594
    PROPAFENONE
    RYTHMOL
    PROPAFENONUM
    1-(2-(2-HYDROXY-3-(PROPYLAMINO)PROPOXY)PHENYL)-3-PHENYL-1-PROPANONE
    2-(2'-HYDROXY-3'-PROPYLAMINOPROPOXY)-OMEGA-PHENYLPROPIOPHENONE
    PROPAFENONA
    ARYTHMOL®
    RYTHMOL®
    chembl:CHEMBL631
    pubchem.compound:4932
    drugbank:01182
    rxcui:8754
    chemidplus:54063-53-5

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiarrythmic agent
    Year of Approval 1989
    Drug Class anti-arrhythmia agents
    (3 More Sources)

    Publications:

    Kroemer HK et al., 1989, Stereoselective disposition and pharmacologic activity of propafenone enantiomers., Circulation
    Klein K et al., 2007, A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6., Drug Metab Dispos
    Toscano C et al., 2006, A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6., Pharmacogenet Genomics
    Chen B et al., 2003, Influence of CYP2D6*10B genotype on pharmacokinetics of propafenone enantiomers in Chinese subjects., Acta Pharmacol Sin
    Cai WM et al., 2002, Effect of CYP2D6*10 genotype on propafenone pharmacodynamics in Chinese patients with ventricular arrhythmia., Acta Pharmacol Sin
    Arias et al., 2003, Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels., Cardiovasc. Res.
    Mergenthaler et al., 2001, Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel., Naunyn Schmiedebergs Arch. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Katchman AN et al., 2006, Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs., J Pharmacol Exp Ther
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Edrich T et al., 2005, State-dependent block of human cardiac hNav1.5 sodium channels by propafenone., J Membr Biol
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
  • PROPAFENONE   COP1

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PROPAFENONE   SCN5A

    Interaction Score: 0.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name propafenone hydrochloride,Rythmol
    Novel drug target Established target

    PMIDs:
    17016423 17139284 16463141


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • PROPAFENONE   KCNH2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name propafenone hydrochloride,Rythmol
    Novel drug target Established target

    PMIDs:
    12618228 11330342 11752352 16278312


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • PROPAFENONE   CYP2D6

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2713973 17460029 17001296 14653957 12421483


    Sources:
    PharmGKB FDA

  • PROPAFENONE   MTOR

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPAFENONE   DRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPAFENONE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROPAFENONE   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • TEND: PROPAFENONE

    • Version: 01-August-2011

    Alternate Names:
    PROPAFENONE Primary Drug Name

    Drug Info:
    Drug Class anti-arrhythmia agents
    Year of Approval 1989

    Publications:

  • TdgClinicalTrial: PROPAFENONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiarrythmic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • PharmGKB: propafenone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Katchman AN et al., 2006, Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs., J Pharmacol Exp Ther
    Kroemer HK et al., 1989, Stereoselective disposition and pharmacologic activity of propafenone enantiomers., Circulation
    Chen B et al., 2003, Influence of CYP2D6*10B genotype on pharmacokinetics of propafenone enantiomers in Chinese subjects., Acta Pharmacol Sin

  • DTC: PROPAFENONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL631 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Propafenone

    • Version: 2020.06.01

    Alternate Names:
    D0J2KV TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL631

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Propafenone

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21