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PROPOXYPHENE Drug Record

  • Summary
  • Interactions
  • Claims
  • PROPOXYPHENE chembl:CHEMBL1213351

    Alternate Names:

    PROPOXYPHENE
    DEXTROPROPOXYPHENE
    LEVOPROPOXYPHENE
    DEXTROPROPOXYPHENUM
    (+)-1,2-DIPHENYL-2-PROPIONOXY-3-METHYL-4-DIMETHYLAMINOBUTANE
    (S)-ALPHA-(2-(DIMETHYLAMINO)-1-METHYLETHYL)-ALPHA-PHENYLBENZENEETHANOL PROPANOATE
    DEXTROPROPOXYPHEN
    4-DIMETHYLAMINO-3-METHYL-1,2-DIPHENYL-2-PROPOXYBUTANE
    DESTROPROPOSSIFENE
    (+)-ALPHA-PROPOXYPHENE
    DEXTROPROPOXYPHÈNE
    ALPHA-D-4-DIMETHYLAMINO-3-METHYL-1,2-DIPHENYL-2-BUTANOL-PROPIONAT
    ALPHA-(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-BUTANOL PROPIONATE ESTER
    DEXTROPROPOXIFENO
    (+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-PROPIONYLOXYBUTANE
    DARVON®
    D-PROPOXYPHENE
    chembl:CHEMBL1213351
    chemidplus:469-62-5
    rxcui:8785
    pubchem.compound:10100
    drugbank:00647

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Antitussive Agents
    Drug Indications Analgesics, Opioid
    Drug Class antitussive agents
    Drug Class analgesics, opioid
    Year of Approval approved before 1982
    Drug Categories diphenylpropylamine derivatives
    Drug Groups investigational
    Drug Categories agents that reduce seizure threshold
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 inhibitors
    Drug Categories cytochrome p-450 cyp3a4 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories high-risk opioids
    Drug Categories opioid agonist
    Drug Categories opioids
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    (3 More Sources)

    Publications:

    Ulens et al., 1999, Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents., Cardiovasc. Res.
    Tyers, 1980, A classification of opiate receptors that mediate antinociception in animals., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Walker et al., 1999, Naltrexone and beta-funaltrexamine antagonism of the antinociceptive and response rate-decreasing effects of morphine, dezocine, and d-propoxyphene., Psychopharmacology (Berl.)
    Bannwarth et al., 2009, The dextropropoxyphene controversy., Joint Bone Spine
    Picker, 1997, Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists., J. Pharmacol. Exp. Ther.
    Codd et al., 1995, Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception., J. Pharmacol. Exp. Ther.
    Neil, 1984, Affinities of some common opioid analgesics towards four binding sites in mouse brain., Naunyn Schmiedebergs Arch. Pharmacol.
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Yin OQ et al., 2010, CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition., J Clin Pharmacol
    Zhang J et al., 1999, Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1., J Pharmacol Exp Ther
  • PROPOXYPHENE   CES1

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10381793


    Sources:
    DrugBank

  • PROPOXYPHENE   OPRM1

    Interaction Score: 0.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10690289 6249436 11752352 10379623 19604717 9399970 7562497


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PROPOXYPHENE   OPRD1

    Interaction Score: 0.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6151117


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PROPOXYPHENE   OPRK1

    Interaction Score: 0.51

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6151117 11752352


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PROPOXYPHENE   CYP3A5

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978 20133509


    Sources:
    PharmGKB

  • DrugBank: DB00647

    • Version: 5.1.7

    Alternate Names:
    DEXTROPROPOXYPHENE DrugBank Drug Name
    469-62-5 CAS Number
    642 Tab Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups illicit

    Publications:
    Neil, 1984, Affinities of some common opioid analgesics towards four binding sites in mouse brain., Naunyn Schmiedebergs Arch. Pharmacol.
    Ulens et al., 1999, Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents., Cardiovasc. Res.
    Tyers, 1980, A classification of opiate receptors that mediate antinociception in animals., Br. J. Pharmacol.

  • TdgClinicalTrial: PROPOXYPHENE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Analgesics, Opioid
    Drug Indications Antitussive Agents
    Drug Class small molecule

    Publications:

  • TEND: PROPOXYPHENE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval approved before 1982
    Drug Class analgesics, opioid
    Drug Class antitussive agents

    Publications:

  • PharmGKB: dextropropoxyphene

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Yin OQ et al., 2010, CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition., J Clin Pharmacol

  • PharmGKB: propoxyphene

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • TTD: Dextropropoxyphene

    • Version: 2020.06.01

    Alternate Names:
    D0D4PB TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1213351

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21