DGIdb - PROPOXYPHENE Drug Record

PROPOXYPHENE chembl:CHEMBL1213351

Alternate Names:

PROPOXYPHENE
DEXTROPROPOXYPHENE
LEVOPROPOXYPHENE
DEXTROPROPOXYPHENUM
(+)-1,2-DIPHENYL-2-PROPIONOXY-3-METHYL-4-DIMETHYLAMINOBUTANE
(S)-ALPHA-(2-(DIMETHYLAMINO)-1-METHYLETHYL)-ALPHA-PHENYLBENZENEETHANOL PROPANOATE
DEXTROPROPOXYPHEN
4-DIMETHYLAMINO-3-METHYL-1,2-DIPHENYL-2-PROPOXYBUTANE
DESTROPROPOSSIFENE
(+)-ALPHA-PROPOXYPHENE
DEXTROPROPOXYPHÈNE
ALPHA-D-4-DIMETHYLAMINO-3-METHYL-1,2-DIPHENYL-2-BUTANOL-PROPIONAT
ALPHA-(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-BUTANOL PROPIONATE ESTER
DEXTROPROPOXIFENO
(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-PROPIONYLOXYBUTANE
DARVON®
D-PROPOXYPHENE
chembl:CHEMBL1213351
chemidplus:469-62-5
rxcui:8785
pubchem.compound:10100
drugbank:00647

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antitussive Agents
Drug Indications	Analgesics, Opioid
Drug Class	antitussive agents
Drug Class	analgesics, opioid
Year of Approval	approved before 1982

(2 More Sources)

Publications:

Picker, 1997, Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists., J. Pharmacol. Exp. Ther.
Walker et al., 1999, Naltrexone and beta-funaltrexamine antagonism of the antinociceptive and response rate-decreasing effects of morphine, dezocine, and d-propoxyphene., Psychopharmacology (Berl.)
Bannwarth et al., 2009, The dextropropoxyphene controversy., Joint Bone Spine
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Codd et al., 1995, Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception., J. Pharmacol. Exp. Ther.
Tyers, 1980, A classification of opiate receptors that mediate antinociception in animals., Br. J. Pharmacol.
Ulens et al., 1999, Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents., Cardiovasc. Res.
Neil, 1984, Affinities of some common opioid analgesics towards four binding sites in mouse brain., Naunyn Schmiedebergs Arch. Pharmacol.
Yin OQ et al., 2010, CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition., J Clin Pharmacol
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

PROPOXYPHENE OPRM1

Interaction Score: 1.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9399970 10379623 19604717 11752352 7562497 6249436 10690289

Sources:
TdgClinicalTrial TEND
PROPOXYPHENE OPRD1

Interaction Score: 1.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6151117

Sources:
TdgClinicalTrial TEND
PROPOXYPHENE OPRK1

Interaction Score: 0.91

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352 6151117

Sources:
TdgClinicalTrial TEND
PROPOXYPHENE CYP3A5

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20133509 18695978

Sources:
PharmGKB

TdgClinicalTrial: PROPOXYPHENE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Analgesics, Opioid

Drug Indications Antitussive Agents

Drug Class small molecule

Publications:
TEND: PROPOXYPHENE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval approved before 1982

Drug Class analgesics, opioid

Drug Class antitussive agents

Publications:
PharmGKB: dextropropoxyphene
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Yin OQ et al., 2010, CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition., J Clin Pharmacol
PharmGKB: propoxyphene
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
TTD: Dextropropoxyphene
- Version: 2020.06.01
Alternate Names:

D0D4PB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1213351
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

PROPOXYPHENE Drug Record

PROPOXYPHENE chembl:CHEMBL1213351

Alternate Names:

Drug Info:

Publications:

PROPOXYPHENE OPRM1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9399970 10379623 19604717 11752352 7562497 6249436 10690289

Sources: TdgClinicalTrial TEND

PROPOXYPHENE OPRD1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6151117

Sources: TdgClinicalTrial TEND

PROPOXYPHENE OPRK1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752352 6151117

Sources: TdgClinicalTrial TEND

PROPOXYPHENE CYP3A5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20133509 18695978

Sources: PharmGKB

TdgClinicalTrial: PROPOXYPHENE

Alternate Names:

Drug Info: Drug Indications Analgesics, Opioid Drug Indications Antitussive Agents Drug Class small molecule

Publications:

TEND: PROPOXYPHENE

Alternate Names:

Drug Info: Year of Approval approved before 1982 Drug Class analgesics, opioid Drug Class antitussive agents

Publications:

PharmGKB: dextropropoxyphene

Alternate Names:

Drug Info:

Publications: Yin OQ et al., 2010, CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition., J Clin Pharmacol

PharmGKB: propoxyphene

Alternate Names:

Drug Info:

Publications: Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

TTD: Dextropropoxyphene

Alternate Names: D0D4PB TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1213351

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9399970 10379623 19604717 11752352 7562497 6249436 10690289

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6151117

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352 6151117

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
20133509 18695978

Sources:
PharmGKB

Drug Info:

Drug Indications Analgesics, Opioid

Drug Indications Antitussive Agents

Drug Class small molecule

Drug Info:

Year of Approval approved before 1982

Drug Class analgesics, opioid

Drug Class antitussive agents

Publications:

Yin OQ et al., 2010, CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition., J Clin Pharmacol

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Alternate Names:

D0D4PB TTD Drug ID