DGIdb - PROPYLTHIOURACIL Drug Record

PROPYLTHIOURACIL chembl:CHEMBL1518 ApprovedImmunotherapy

Alternate Names:

NSC-6498
PROTHYRAN
THYREOSTAT
PROPYLTHIOURACIL
NSC-70461
PROPACIL
6-PROPYLTHIOURACIL
2-MERCAPTO-6-PROPYLPYRIMID-4-ONE
THYREOSTAT®
2-MERCAPTO-6-PROPYL-4-PYRIMIDONE
2,3-DIHYDRO-6-PROPYL-2-THIOXO-4(1H)-PYRIMIDINONE
6-PROPYL-2-THIOURACIL
PROPILTIOURACILO
2-THIO-4-OXO-6-PROPYL-1,3-PYRIMIDINE
6-PROPYL-2-THIO-2,4(1H,3H)PYRIMIDINEDIONE
PROPYLTHIOURACILUM
6-PROPYL-2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE
6-THIO-4-PROPYLURACIL
PROPYLTHIOURACILE
4-PROPYL-2-THIOURACIL
2-THIO-6-PROPYL-1,3-PYRIMIDIN-4-ONE
drugbank:00550
chemidplus:51-52-5
pubchem.compound:657298
rxcui:8794
chembl:CHEMBL1518

Drug Info:

Drug Class	antithyroid agents
Year of Approval	1947
FDA Approval	1947
Drug Class	small molecule
Drug Indications	Antithyroid Agents

(4 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Elias et al., 1995, Effect of orally administered antithyroid thioureylenes on PCNA and P53 expression in psoriatic lesions., Int. J. Dermatol.
Park et al., 2002, Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle., J. Appl. Physiol.
Rillema et al., 1997, Characteristics of the prolactin stimulation of iodide uptake into mouse mammary gland explants., Proc. Soc. Exp. Biol. Med.
Cartmill et al., 2003, Effects of dexamethasone, glucose infusion, adrenocorticotropin, and propylthiouracil on plasma leptin concentrations in horses., Domest. Anim. Endocrinol.
Ferreira et al., 2003, Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole., Eur. J. Biochem.
Manzon et al., 2001, Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus)., J. Exp. Zool.
Schmutzler et al., 2007, The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase., Endocrinology
Sugawara et al., 1999, Methimazole and propylthiouracil increase cellular thyroid peroxidase activity and thyroid peroxidase mRNA in cultured porcine thyroid follicles., Thyroid
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Taurog et al., 1989, A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil., Endocrinology
St-Pierre et al., 2003, Neonatal hypothyroidism alters the localization of gap junctional protein connexin 43 in the testis and messenger RNA levels in the epididymis of the rat., Biol. Reprod.
Sillau, 1985, Capillarity, oxidative capacity and fibre composition of the soleus and gastrocnemius muscles of rats in hypothyroidism., J. Physiol. (Lond.)
Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem
Elias et al., 2004, Serum TNF-alpha in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene., BMC Dermatol.
Vaidya et al., 2001, Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression., Neuropharmacology
Elias et al., 1993, Effect of propylthiouracil and methimazole on serum levels of interleukin-2 receptors in patients with psoriasis., Int. J. Dermatol.

PROPYLTHIOURACIL TPO

Interaction Score: 12.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thyroid peroxidase inhibitor

PMIDs:
12755690 11241400 17379648 10365684 11752352 2656250

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
PROPYLTHIOURACIL DIO1

Interaction Score: 7.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Type I iodothyronine deiodinase (Type-I 5'deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
PROPYLTHIOURACIL PRKAB1

Interaction Score: 1.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12433937

Sources:
NCI
PROPYLTHIOURACIL GJA1

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12606457

Sources:
NCI
PROPYLTHIOURACIL MYO9B

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3989729

Sources:
NCI
PROPYLTHIOURACIL LEP

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12450621

Sources:
NCI
PROPYLTHIOURACIL MPO

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26509551

Sources:
DTC
PROPYLTHIOURACIL IL2RA

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8340196

Sources:
NCI
PROPYLTHIOURACIL PRL

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9270719

Sources:
NCI
PROPYLTHIOURACIL HLA-DRB1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PROPYLTHIOURACIL BDNF

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11077070

Sources:
NCI
PROPYLTHIOURACIL TNF

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15119959

Sources:
NCI
PROPYLTHIOURACIL TP53

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7790147

Sources:
NCI
PROPYLTHIOURACIL CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROPYLTHIOURACIL CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROPYLTHIOURACIL CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROPYLTHIOURACIL CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: PROPYLTHIOURACIL
- Version: 01-August-2011
Alternate Names:

PROPYLTHIOURACIL Primary Drug Name

Drug Info:

Year of Approval 1947

Drug Class antithyroid agents

Publications:
TdgClinicalTrial: PROPYLTHIOURACIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antithyroid Agents

Drug Class small molecule

FDA Approval 1947

Publications:

NCI: PROPYLTHIOURACIL

Version: 14-September-2017

Alternate Names:

C781 NCI drug code

Drug Info:

Publications:

Sillau, 1985, Capillarity, oxidative capacity and fibre composition of the soleus and gastrocnemius muscles of rats in hypothyroidism., J. Physiol. (Lond.)

Cartmill et al., 2003, Effects of dexamethasone, glucose infusion, adrenocorticotropin, and propylthiouracil on plasma leptin concentrations in horses., Domest. Anim. Endocrinol.

Vaidya et al., 2001, Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression., Neuropharmacology

DTC: PROPYLTHIOURACIL

Version: 02-September-2020

Alternate Names:

CHEMBL1518 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem

TTD: Propylthiouracil
- Version: 2020.06.01
Alternate Names:

D00MIN TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1518
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1518
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: propylthiouracil
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Thyroid peroxidase inhibitor

Direct Interaction	yes
Mechanism of Interaction	Type I iodothyronine deiodinase (Type-I 5'deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor

PROPYLTHIOURACIL Drug Record

PROPYLTHIOURACIL chembl:CHEMBL1518 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Thyroid peroxidase inhibitor

PMIDs: 12755690 11241400 17379648 10365684 11752352 2656250

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Type I iodothyronine deiodinase (Type-I 5&apos;deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12433937

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12606457

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3989729

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12450621

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26509551

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8340196

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9270719

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11077070

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15119959

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7790147

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: PROPYLTHIOURACIL

Alternate Names: PROPYLTHIOURACIL Primary Drug Name

Drug Info: Year of Approval 1947 Drug Class antithyroid agents

Publications:

TdgClinicalTrial: PROPYLTHIOURACIL

Alternate Names:

Drug Info: Drug Indications Antithyroid Agents Drug Class small molecule FDA Approval 1947

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thyroid peroxidase inhibitor

PMIDs:
12755690 11241400 17379648 10365684 11752352 2656250

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Type I iodothyronine deiodinase (Type-I 5'deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
12433937

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12606457

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3989729

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12450621

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26509551

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
8340196

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9270719

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11077070

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15119959

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7790147

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

PROPYLTHIOURACIL Primary Drug Name

Drug Info:

Year of Approval 1947

Drug Class antithyroid agents

Drug Info:

Drug Indications Antithyroid Agents

Drug Class small molecule

FDA Approval 1947

Alternate Names:

C781 NCI drug code

Alternate Names:

CHEMBL1518 ChEMBL Drug ID

Alternate Names:

D00MIN TTD Drug ID