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PROPYLTHIOURACIL Drug Record

  • Summary
  • Interactions
  • Claims
  • PROPYLTHIOURACIL chembl:CHEMBL1518 ApprovedImmunotherapy

    Alternate Names:

    NSC-6498
    PROTHYRAN
    THYREOSTAT
    PROPYLTHIOURACIL
    NSC-70461
    PROPACIL
    6-PROPYLTHIOURACIL
    2-MERCAPTO-6-PROPYLPYRIMID-4-ONE
    THYREOSTAT®
    2-MERCAPTO-6-PROPYL-4-PYRIMIDONE
    2,3-DIHYDRO-6-PROPYL-2-THIOXO-4(1H)-PYRIMIDINONE
    6-PROPYL-2-THIOURACIL
    PROPILTIOURACILO
    2-THIO-4-OXO-6-PROPYL-1,3-PYRIMIDINE
    6-PROPYL-2-THIO-2,4(1H,3H)PYRIMIDINEDIONE
    PROPYLTHIOURACILUM
    6-PROPYL-2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE
    6-THIO-4-PROPYLURACIL
    PROPYLTHIOURACILE
    4-PROPYL-2-THIOURACIL
    2-THIO-6-PROPYL-1,3-PYRIMIDIN-4-ONE
    drugbank:00550
    chemidplus:51-52-5
    pubchem.compound:657298
    rxcui:8794
    chembl:CHEMBL1518

    Drug Info:

    Drug Class antithyroid agents
    Year of Approval 1947
    FDA Approval 1947
    Drug Class small molecule
    Drug Indications Antithyroid Agents
    (4 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Elias et al., 1995, Effect of orally administered antithyroid thioureylenes on PCNA and P53 expression in psoriatic lesions., Int. J. Dermatol.
    Park et al., 2002, Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle., J. Appl. Physiol.
    Rillema et al., 1997, Characteristics of the prolactin stimulation of iodide uptake into mouse mammary gland explants., Proc. Soc. Exp. Biol. Med.
    Cartmill et al., 2003, Effects of dexamethasone, glucose infusion, adrenocorticotropin, and propylthiouracil on plasma leptin concentrations in horses., Domest. Anim. Endocrinol.
    Ferreira et al., 2003, Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole., Eur. J. Biochem.
    Manzon et al., 2001, Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus)., J. Exp. Zool.
    Schmutzler et al., 2007, The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase., Endocrinology
    Sugawara et al., 1999, Methimazole and propylthiouracil increase cellular thyroid peroxidase activity and thyroid peroxidase mRNA in cultured porcine thyroid follicles., Thyroid
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Taurog et al., 1989, A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil., Endocrinology
    St-Pierre et al., 2003, Neonatal hypothyroidism alters the localization of gap junctional protein connexin 43 in the testis and messenger RNA levels in the epididymis of the rat., Biol. Reprod.
    Sillau, 1985, Capillarity, oxidative capacity and fibre composition of the soleus and gastrocnemius muscles of rats in hypothyroidism., J. Physiol. (Lond.)
    Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem
    Elias et al., 2004, Serum TNF-alpha in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene., BMC Dermatol.
    Vaidya et al., 2001, Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression., Neuropharmacology
    Elias et al., 1993, Effect of propylthiouracil and methimazole on serum levels of interleukin-2 receptors in patients with psoriasis., Int. J. Dermatol.
  • PROPYLTHIOURACIL   TPO

    Interaction Score: 12.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Thyroid peroxidase inhibitor

    PMIDs:
    12755690 11241400 17379648 10365684 11752352 2656250


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PROPYLTHIOURACIL   DIO1

    Interaction Score: 7.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Type I iodothyronine deiodinase (Type-I 5'deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • PROPYLTHIOURACIL   PRKAB1

    Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12433937


    Sources:
    NCI

  • PROPYLTHIOURACIL   GJA1

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12606457


    Sources:
    NCI

  • PROPYLTHIOURACIL   MYO9B

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3989729


    Sources:
    NCI

  • PROPYLTHIOURACIL   LEP

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12450621


    Sources:
    NCI

  • PROPYLTHIOURACIL   MPO

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26509551


    Sources:
    DTC

  • PROPYLTHIOURACIL   IL2RA

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8340196


    Sources:
    NCI

  • PROPYLTHIOURACIL   PRL

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9270719


    Sources:
    NCI

  • PROPYLTHIOURACIL   HLA-DRB1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROPYLTHIOURACIL   BDNF

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11077070


    Sources:
    NCI

  • PROPYLTHIOURACIL   TNF

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15119959


    Sources:
    NCI

  • PROPYLTHIOURACIL   TP53

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7790147


    Sources:
    NCI

  • PROPYLTHIOURACIL   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PROPYLTHIOURACIL   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PROPYLTHIOURACIL   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PROPYLTHIOURACIL   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: PROPYLTHIOURACIL

    • Version: 01-August-2011

    Alternate Names:
    PROPYLTHIOURACIL Primary Drug Name

    Drug Info:
    Year of Approval 1947
    Drug Class antithyroid agents

    Publications:

  • TdgClinicalTrial: PROPYLTHIOURACIL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antithyroid Agents
    Drug Class small molecule
    FDA Approval 1947

    Publications:

  • NCI: PROPYLTHIOURACIL

    • Version: 14-September-2017

    Alternate Names:
    C781 NCI drug code

    Drug Info:

    Publications:
    Sillau, 1985, Capillarity, oxidative capacity and fibre composition of the soleus and gastrocnemius muscles of rats in hypothyroidism., J. Physiol. (Lond.)
    Cartmill et al., 2003, Effects of dexamethasone, glucose infusion, adrenocorticotropin, and propylthiouracil on plasma leptin concentrations in horses., Domest. Anim. Endocrinol.
    Vaidya et al., 2001, Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression., Neuropharmacology

  • DTC: PROPYLTHIOURACIL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1518 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Ruggeri RB et al., 2015, Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases., J Med Chem

  • TTD: Propylthiouracil

    • Version: 2020.06.01

    Alternate Names:
    D00MIN TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1518

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1518

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: propylthiouracil

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21