DGIdb - PYRIDOSTIGMINE Drug Record

PYRIDOSTIGMINE chembl:CHEMBL1115 Approved

Alternate Names:

REGONOL
MESTINON
PYRIDOSTIGMINE
MESTINON®
REGONOL®
BROMURO DE PIRIDOSTIGMINA
PYRIDOSTIGMIN BROMID
BROMURE DE PYRIDOSTIGMINE
PYRIDOSTIGMINI BROMIDUM
pubchem.compound:4991
chemidplus:155-97-5
rxcui:9000
chembl:CHEMBL1115
drugbank:00545

Drug Info:

Drug Class	antimyasthenics
Year of Approval	1955
Drug Class	small molecule
Drug Indications	Antimyasthenics
FDA Approval	1955

(2 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Ricordel et al., 2000, [Chemical weapons: antidotes. View about the real means, perspectives]., Ann Pharm Fr
Servatius et al., 2000, Effects of inescapable stress and treatment with pyridostigmine bromide on plasma butyrylcholinesterase and the acoustic startle response in rats., Physiol. Behav.
Drake-Baumann et al., 1999, Effects of exposure to low-dose pyridostigmine on neuromuscular junctions in vitro., Muscle Nerve
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Prasad et al., 2000, Interactions of bovine brain tubulin with pyridostigmine bromide and N,N'-diethyl-m-toluamide., Neurochem. Res.
Sinton et al., 2000, Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the Rat., Toxicol. Appl. Pharmacol.
Somani et al., Interactive and delayed effects of pyridostigmine and physical stress on biochemical and histological changes in peripheral tissues of mice., J Appl Toxicol
Abou-Donia et al., 1996, Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos., Fundam Appl Toxicol

PYRIDOSTIGMINE ACHE

Interaction Score: 2.22

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
10669805 10869589 10366222 11752352 10685600 10814558

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
PYRIDOSTIGMINE BCHE

Interaction Score: 1.74

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10942908 10869589 8954750

Sources:
GuideToPharmacology
PYRIDOSTIGMINE CBX1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYRIDOSTIGMINE CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PYRIDOSTIGMINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PYRIDOSTIGMINE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PYRIDOSTIGMINE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: PYRIDOSTIGMINE
- Version: 01-August-2011
Alternate Names:

PYRIDOSTIGMINE Primary Drug Name

Drug Info:

Year of Approval 1955

Drug Class antimyasthenics

Publications:
TdgClinicalTrial: PYRIDOSTIGMINE
- Version: January-2014
Alternate Names:

Drug Info:

FDA Approval 1955

Drug Indications Antimyasthenics

Drug Class small molecule

Publications:
DTC: PYRIDOSTIGMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1115 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
GuideToPharmacology: 310264772
- Version: 29-September-2020
Alternate Names:

PYRIDOSTIGMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Pyridostigmine
- Version: 2020.06.01
Alternate Names:

D0O2WB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1115
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Details of the Assay for Interaction	Inhibition of human plasma BCHE activity by a modified Ellman assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

antagonist (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

PYRIDOSTIGMINE Drug Record

PYRIDOSTIGMINE chembl:CHEMBL1115 Approved

Alternate Names:

Drug Info:

Publications:

PYRIDOSTIGMINE ACHE

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 10669805 10869589 10366222 11752352 10685600 10814558

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

PYRIDOSTIGMINE BCHE

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 10942908 10869589 8954750

Sources: GuideToPharmacology

PYRIDOSTIGMINE CBX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

PYRIDOSTIGMINE CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

PYRIDOSTIGMINE CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

PYRIDOSTIGMINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

PYRIDOSTIGMINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: PYRIDOSTIGMINE

Alternate Names: PYRIDOSTIGMINE Primary Drug Name

Drug Info: Year of Approval 1955 Drug Class antimyasthenics

Publications:

TdgClinicalTrial: PYRIDOSTIGMINE

Alternate Names:

Drug Info: FDA Approval 1955 Drug Indications Antimyasthenics Drug Class small molecule

Publications:

DTC: PYRIDOSTIGMINE

Alternate Names: CHEMBL1115 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

GuideToPharmacology: 310264772

Alternate Names: PYRIDOSTIGMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Pyridostigmine

Alternate Names: D0O2WB TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1115

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
10669805 10869589 10366222 11752352 10685600 10814558

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10942908 10869589 8954750

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

PYRIDOSTIGMINE Primary Drug Name

Drug Info:

Year of Approval 1955

Drug Class antimyasthenics

Drug Info:

FDA Approval 1955

Drug Indications Antimyasthenics

Drug Class small molecule

Alternate Names:

CHEMBL1115 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

PYRIDOSTIGMINE GuideToPharmacology Ligand Name

Alternate Names:

D0O2WB TTD Drug ID