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PYRIMETHAMINE Drug Record

  • Summary
  • Interactions
  • Claims
  • PYRIMETHAMINE chembl:CHEMBL36 Approved

    Alternate Names:

    PYRIMETHAMINE
    NSC-3061
    WR-2978
    GNF-PF-5586
    CHLORIDIN
    MALACIDE
    DARAPRIM
    TCMDC-125860
    RP-4753
    TCMDC-123831
    PIRIMETAMINA
    DARAPRIM®
    DIAMINOPYRITAMIN
    CHLORIDINE
    ETHYLPYRIMIDINE
    2,4-DIAMINO-5-(P-CHLOROPHENYL)-6-ETHYLPYRIMIDINE
    PYRIMETHAMINUM
    5-(4-CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE
    CHLORIDYN
    2,4-DIAMINO-5-CHLOROPHENYL-6-ETHYLPYRIMIDINE
    5-(4'-CHLOROPHENYL)-2,4-DIAMINO-6-ETHYLPYRIMIDINE
    2,4-DIAMINO-5-(4-CHLOROPHENYL)-6-ETHYLPYRIMIDINE
    PRIMETHAMINE
    CD
    5-(4-CHLOROPHENYL)-6-ETHYL-2,4-DIAMINOPYRIMIDINE
    pubchem.compound:4993
    chemidplus:58-14-0
    drugbank:00205
    rxcui:9010
    chembl:CHEMBL36

    Drug Info:

    (1 More Sources)

    Publications:

    Fidock et al., 1997, Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil., Proc. Natl. Acad. Sci. U.S.A.
    Wooden et al., 1997, Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum., Mol. Biochem. Parasitol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Rastelli et al., 2003, Structure of Plasmodium vivax dihydrofolate reductase determined by homology modeling and molecular dynamics refinement., Bioorg. Med. Chem. Lett.
    Tropak MB et al., 2015, Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity., J Med Chem
    Mukanganyama S et al., 2002, Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance., Int J Cancer
    Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.
    Maegawa GH et al., 2007, Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis., J Biol Chem
  • PYRIMETHAMINE   HEXA

    Interaction Score: 3.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17237499 25984755


    Sources:
    DTC

  • PYRIMETHAMINE   DHFR

    Interaction Score: 2.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    9380737 9108546 11752352 12951104 25984755


    Sources:
    DTC

  • PYRIMETHAMINE   IKBKG

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PYRIMETHAMINE   ACP1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PYRIMETHAMINE   FOLR1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PYRIMETHAMINE   STAT3

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25984755


    Sources:
    DTC

  • PYRIMETHAMINE   IL2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3497888


    Sources:
    NCI

  • PYRIMETHAMINE   GSTP1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11807801


    Sources:
    PharmGKB

  • PYRIMETHAMINE   IDH1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PYRIMETHAMINE   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DTC: PYRIMETHAMINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL36 ChEMBL Drug ID

    Drug Info:

    Publications:
    Tropak MB et al., 2015, Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity., J Med Chem
    Maegawa GH et al., 2007, Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis., J Biol Chem

  • NCI: PYRIMETHAMINE

    • Version: 14-September-2017

    Alternate Names:
    C788 NCI drug code

    Drug Info:

    Publications:
    Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.

  • PharmGKB: pyrimethamine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Mukanganyama S et al., 2002, Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance., Int J Cancer

  • TTD: Pyrimethamine

    • Version: 2020.06.01

    Alternate Names:
    D0C0SK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL36

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21