DGIdb - PYRIMETHAMINE Drug Record

PYRIMETHAMINE chembl:CHEMBL36 Approved

Alternate Names:

PYRIMETHAMINE
NSC-3061
WR-2978
GNF-PF-5586
CHLORIDIN
MALACIDE
DARAPRIM
TCMDC-125860
RP-4753
TCMDC-123831
PIRIMETAMINA
DARAPRIM®
DIAMINOPYRITAMIN
CHLORIDINE
ETHYLPYRIMIDINE
2,4-DIAMINO-5-(P-CHLOROPHENYL)-6-ETHYLPYRIMIDINE
PYRIMETHAMINUM
5-(4-CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE
CHLORIDYN
2,4-DIAMINO-5-CHLOROPHENYL-6-ETHYLPYRIMIDINE
5-(4'-CHLOROPHENYL)-2,4-DIAMINO-6-ETHYLPYRIMIDINE
2,4-DIAMINO-5-(4-CHLOROPHENYL)-6-ETHYLPYRIMIDINE
PRIMETHAMINE
CD
5-(4-CHLOROPHENYL)-6-ETHYL-2,4-DIAMINOPYRIMIDINE
pubchem.compound:4993
chemidplus:58-14-0
drugbank:00205
rxcui:9010
chembl:CHEMBL36

Drug Info:

(2 More Sources)

Publications:

Fidock et al., 1997, Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil., Proc. Natl. Acad. Sci. U.S.A.
Wooden et al., 1997, Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum., Mol. Biochem. Parasitol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rastelli et al., 2003, Structure of Plasmodium vivax dihydrofolate reductase determined by homology modeling and molecular dynamics refinement., Bioorg. Med. Chem. Lett.
Tropak MB et al., 2015, Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity., J Med Chem
Mukanganyama S et al., 2002, Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance., Int J Cancer
Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.
Maegawa GH et al., 2007, Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis., J Biol Chem

PYRIMETHAMINE HEXA

Interaction Score: 3.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17237499 25984755

Sources:
DTC
PYRIMETHAMINE DHFR

Interaction Score: 2.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9380737 9108546 11752352 12951104 25984755

Sources:
DTC
PYRIMETHAMINE IKBKG

Interaction Score: 1.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PYRIMETHAMINE SLC47A1

Interaction Score: 1.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PYRIMETHAMINE ACP1

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYRIMETHAMINE FOLR1

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PYRIMETHAMINE STAT3

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25984755

Sources:
DTC
PYRIMETHAMINE IL2

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3497888

Sources:
NCI
PYRIMETHAMINE GSTP1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11807801

Sources:
PharmGKB
PYRIMETHAMINE IDH1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYRIMETHAMINE AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: PYRIMETHAMINE

Version: 02-September-2020

Alternate Names:

CHEMBL36 ChEMBL Drug ID

Drug Info:

Publications:

Tropak MB et al., 2015, Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity., J Med Chem

Maegawa GH et al., 2007, Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis., J Biol Chem

NCI: PYRIMETHAMINE
- Version: 14-September-2017
Alternate Names:

C788 NCI drug code

Drug Info:

Publications:

Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.
PharmGKB: pyrimethamine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Mukanganyama S et al., 2002, Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance., Int J Cancer
TTD: Pyrimethamine
- Version: 2020.06.01
Alternate Names:

D0C0SK TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178101502
- Version: 29-September-2020
Alternate Names:

PYRIMETHAMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL36
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

PYRIMETHAMINE Drug Record

PYRIMETHAMINE chembl:CHEMBL36 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17237499 25984755

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9380737 9108546 11752352 12951104 25984755

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25984755

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3497888

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11807801

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DTC: PYRIMETHAMINE

Alternate Names: CHEMBL36 ChEMBL Drug ID

Drug Info:

NCI: PYRIMETHAMINE

Alternate Names: C788 NCI drug code

Drug Info:

Publications: Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.

PharmGKB: pyrimethamine

Alternate Names:

Drug Info:

Publications: Mukanganyama S et al., 2002, Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance., Int J Cancer

TTD: Pyrimethamine

Alternate Names: D0C0SK TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178101502

Alternate Names: PYRIMETHAMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL36

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17237499 25984755

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9380737 9108546 11752352 12951104 25984755

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
25984755

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
3497888

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11807801

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL36 ChEMBL Drug ID

Alternate Names:

C788 NCI drug code

Publications:

Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.

Publications:

Mukanganyama S et al., 2002, Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance., Int J Cancer

Alternate Names:

D0C0SK TTD Drug ID

Alternate Names:

PYRIMETHAMINE GuideToPharmacology Ligand Name