DGIdb - RABEPRAZOLE Drug Record

RABEPRAZOLE chembl:CHEMBL1219 Approved

Alternate Names:

RABEPRAZOLE
LY-307640
ACIPHEX
E3810
E-3810 (PPI)
LY307640
E-3810
ACIPHEX®
PARIET®
CLOFEZONE
chembl:CHEMBL1219
rxcui:114979
drugbank:01129
pubchem.compound:5029
chemidplus:117976-89-3

Drug Info:

Drug Class	gi anti-ulcer agents, proton-pump inhibitors
Year of Approval	1999
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	Proton pump inhibitor

(4 More Sources)

Publications:

Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.
Zhang L et al., 2010, The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people., J Clin Pharm Ther
Take S et al., 2003, Interleukin-1beta genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection., Am J Gastroenterol
Langtry et al., 1999, Rabeprazole: a review of its use in acid-related gastrointestinal disorders., Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Carswell et al., 2001, Rabeprazole: an update of its use in acid-related disorders., Drugs
Fujisaki et al., 1998, Effects of rabeprazole, a gastric proton pump inhibitor, on biliary and hepatic lysosomal enzymes in rats., Jpn. J. Pharmacol.

RABEPRAZOLE ATP4A

Interaction Score: 2.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Aciphex

Novel drug target Established target

PMIDs:
10551440 11752352 11772142

Sources:
TdgClinicalTrial TEND TTD
RABEPRAZOLE HEXB

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9593221

Sources:
NCI
RABEPRAZOLE IL10

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16815316

Sources:
NCI
RABEPRAZOLE IL1B

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21054464 16815316 14638340

Sources:
PharmGKB
RABEPRAZOLE ATP4B

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
RABEPRAZOLE TNF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16815316

Sources:
NCI
RABEPRAZOLE ALOX15B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RABEPRAZOLE ALDH1A1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RABEPRAZOLE MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RABEPRAZOLE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RABEPRAZOLE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
RABEPRAZOLE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: RABEPRAZOLE
- Version: 01-August-2011
Alternate Names:

RABEPRAZOLE Primary Drug Name

Drug Info:

Year of Approval 1999

Drug Class gi anti-ulcer agents, proton-pump inhibitors

Publications:
TdgClinicalTrial: RABEPRAZOLE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Proton pump inhibitor

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: RABEPRAZOLE

Version: 14-September-2017

Alternate Names:

C29410 NCI drug code

Drug Info:

Publications:

Fujisaki et al., 1998, Effects of rabeprazole, a gastric proton pump inhibitor, on biliary and hepatic lysosomal enzymes in rats., Jpn. J. Pharmacol.

Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.

PharmGKB: rabeprazole

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.

Zhang L et al., 2010, The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people., J Clin Pharm Ther

Take S et al., 2003, Interleukin-1beta genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection., Am J Gastroenterol

DTC: RABEPRAZOLE
- Version: 02-September-2020
Alternate Names:

CHEMBL1219 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Rabeprazole
- Version: 2020.06.01
Alternate Names:

D0KL4J TTD Drug ID

Drug Info:

Publications:
FDA: Rabeprazole
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1219
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	Aciphex
Novel drug target	Established target

RABEPRAZOLE Drug Record

RABEPRAZOLE chembl:CHEMBL1219 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Aciphex Novel drug target Established target

PMIDs: 10551440 11752352 11772142

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9593221

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16815316

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21054464 16815316 14638340

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16815316

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: RABEPRAZOLE

Alternate Names: RABEPRAZOLE Primary Drug Name

Drug Info: Year of Approval 1999 Drug Class gi anti-ulcer agents, proton-pump inhibitors

Publications:

TdgClinicalTrial: RABEPRAZOLE

Alternate Names:

Drug Info: Drug Indications Proton pump inhibitor Drug Class Small Molecule FDA Approval approved

Publications:

NCI: RABEPRAZOLE

Alternate Names: C29410 NCI drug code

Drug Info:

PharmGKB: rabeprazole

Alternate Names:

Drug Info:

DTC: RABEPRAZOLE

Alternate Names: CHEMBL1219 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Rabeprazole

Alternate Names: D0KL4J TTD Drug ID

Drug Info:

Publications:

FDA: Rabeprazole

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1219

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Aciphex

Novel drug target Established target

PMIDs:
10551440 11752352 11772142

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
9593221

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16815316

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21054464 16815316 14638340

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
16815316

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

RABEPRAZOLE Primary Drug Name

Drug Info:

Year of Approval 1999

Drug Class gi anti-ulcer agents, proton-pump inhibitors

Drug Info:

Drug Indications Proton pump inhibitor

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29410 NCI drug code

Alternate Names:

CHEMBL1219 ChEMBL Drug ID

Alternate Names:

D0KL4J TTD Drug ID