• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

RASBURICASE Drug Record

  • Summary
  • Interactions
  • Claims
  • RASBURICASE chembl:CHEMBL1201594 Approved

    Alternate Names:

    URATE OXIDASE
    SR-29142
    RASBURICASE
    ELITEK
    FASTURTEC
    URICASE
    rxcui:283821
    drugbank:00049
    chembl:CHEMBL1201594
    chemidplus:134774-45-1

    Drug Info:

    (0 More Sources)

    Publications:

    Pui CH et al., 1997, Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies., Leukemia
    Akande M et al., 2017, Rasburicase-induced Hemolytic Anemia in an Adolescent With Unknown Glucose-6-Phosphate Dehydrogenase Deficiency., J Pediatr Pharmacol Ther
    Cooling L, 2017, Brisk clinical response to erythrocytapheresis in a G6PD-deficient patient with rasburicase-induced methemoglobinemia., J Clin Apher
    Montgomery KW et al., 2017, A perfect storm: Tumor lysis syndrome with rasburicase-induced methemoglobinemia in a G6PD deficient adult., J Clin Apher
    Oluwasanjo A et al., 2015, Rasburicase-induced methaemoglobinaemia and G6PD deficiency in an unusual suspect., Br J Haematol
    Zhang B et al., 2014, Tumor lysis syndrome and acute anemia in an African-American man with chronic lymphocytic leukemia., Oxf Med Case Reports
    Bontant T et al., 2014, Methaemoglobinaemia in a G6PD-deficient child treated with rasburicase., BMJ Case Rep
    McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
    Relling MV et al., 2014, Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype., Clin Pharmacol Ther
    Roberts DA et al., 2015, Rasburicase-induced methemoglobinemia in two African-American female patients: an under-recognized and continued problem., Eur J Haematol
    Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol
    Pansy J et al., 2014, Cyanosis in a male Nigerian infant with acute kidney injury: answers., Pediatr Nephrol
    Cheah CY et al., 2013, Rasburicase causing severe oxidative hemolysis and methemoglobinemia in a patient with previously unrecognized glucose-6-phosphate dehydrogenase deficiency., Acta Haematol
    Zaramella P et al., 2013, Lethal effect of a single dose of rasburicase in a preterm newborn infant., Pediatrics
    Sonbol MB et al., 2013, Methemoglobinemia and hemolysis in a patient with G6PD deficiency treated with rasburicase., Am J Hematol
    Ng JS et al., 2012, Methemoglobinemia induced by rasburicase in a pediatric patient: a case report and literature review., J Oncol Pharm Pract
    Vadhan-Raj S et al., 2012, A randomized trial of a single-dose rasburicase versus five-daily doses in patients at risk for tumor lysis syndrome., Ann Oncol
    Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf
    Bain BJ, 2010, A ghostly presence-G6PD deficiency., Am J Hematol
    Ducros J et al., 1991, Hemolytic anemia due to G6PD deficiency and urate oxidase in a kidney-transplant patient., Clin Nephrol
    Joly P et al., 2009, [A severe G6PD deficiency revealed during a chemotherapy protocol including rasburicase]., Ann Biol Clin (Paris)
    Bhat P et al., 2008, Exchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient., Pediatr Blood Cancer
    Borinstein SC et al., 2008, Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia., Pediatr Blood Cancer
    Browning LA et al., 2005, Hemolysis and methemoglobinemia secondary to rasburicase administration., Ann Pharmacother
    Bosly A et al., 2003, Rasburicase (recombinant urate oxidase) for the management of hyperuricemia in patients with cancer: report of an international compassionate use study., Cancer
    Patte C et al., 2002, Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Française d'Oncologie Pédiatrique LMB89 protocol., Ann Oncol
  • RASBURICASE   G6PD

    Interaction Score: 4.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9369411 29290749 28370399 27119769 26033222 25988058 25115783 24915143 24787449 24750455 24372186 23989394 23860572 23209099 22573495 22190578 22015451 20701405 20196170 2019023 19654083 18561168 17387701 16204390 12942574 12075750


    Sources:
    PharmGKB FDA

  • RASBURICASE   CYB5R2

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RASBURICASE   CYB5R4

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RASBURICASE   CYB5R1

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RASBURICASE   CYB5R3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PharmGKB: rasburicase

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Borinstein SC et al., 2008, Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia., Pediatr Blood Cancer
    Pansy J et al., 2014, Cyanosis in a male Nigerian infant with acute kidney injury: answers., Pediatr Nephrol
    Bain BJ, 2010, A ghostly presence-G6PD deficiency., Am J Hematol

  • ChemblDrugs: chembl:CHEMBL1201594

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Rasburicase

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21