DGIdb - REGRAMOSTIM Drug Record

REGRAMOSTIM chembl:CHEMBL2107881 Antineoplastic

Alternate Names:

GM-CSF
RHGM-CSF
RHGM-C
GMC-89-107
REGRAMOSTIM
GM-CSF (CHO CELL)

Drug Info:

Drug Indications	antineoplastic agent,vaccine
FDA Approval	not approved
Drug Class	protein
Drug Indications	antineoplastic agent

(0 More Sources)

Publications:

Joseph et al., 1996, S6 kinase p90rsk in granulocyte-macrophage colony-stimulating factor-stimulated proliferative and mature hematopoietic cells., J. Biol. Chem.
Kikuchi et al., 2004, Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes., Int. Immunol.
Hellmich et al., 2000, Granulocyte-macrophage colony-stimulating factor (GM-CSF) but not granulocyte colony-stimulating factor (G-CSF) induces plasma membrane expression of proteinase 3 (PR3) on neutrophils in vitro., Clin. Exp. Immunol.
Hamilton et al., 1993, Macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor stimulate the synthesis of plasminogen-activator inhibitors by human monocytes., Blood
Xue et al., 2005, [Factors regulating expression of antiapoptosis gene survivin]., Zhongguo Shi Yan Xue Ye Xue Za Zhi
Jinquan et al., 2001, CXCR3 expression on CD34(+) hemopoietic progenitors induced by granulocyte-macrophage colony-stimulating factor: II. Signaling pathways involved., J. Immunol.
Evans et al., 1989, The effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on human osteoblast-like cells., Biochem. Biophys. Res. Commun.
Fuhler et al., 2004, Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia., J. Leukoc. Biol.
Chen et al., 2003, GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-beta receptors., Am. J. Physiol. Lung Cell Mol. Physiol.
Wong et al., 2003, Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-[kappa] B., Am. J. Respir. Cell Mol. Biol.
Welker et al., GM-CSF downregulates expression of tryptase, Fc epsilon RI and histamine in HMC-1 mast cells., Int. Arch. Allergy Immunol.
Dogan et al., 2003, Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease., J. Immunol.
Savion et al., 1999, A possible role for granulocyte macrophage-colony stimulating factor in modulating teratogen-induced effects., Teratog., Carcinog. Mutagen.

REGRAMOSTIM TGFBR3

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12471017

Sources:
NCI
REGRAMOSTIM PRTN3

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10792393

Sources:
NCI
REGRAMOSTIM TPSAB1

Interaction Score: 2.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9130550

Sources:
NCI
REGRAMOSTIM CD5

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10379842

Sources:
NCI
REGRAMOSTIM ICAM3

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12600815

Sources:
NCI
REGRAMOSTIM TP73

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15126418

Sources:
NCI
REGRAMOSTIM CSF2RA

Interaction Score: 0.69

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name DISC GM-CSF

Novel drug target Established target

Trial Name E75,N/

PMIDs:
None found

Sources:
TdgClinicalTrial
REGRAMOSTIM CXCL10

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11591765

Sources:
NCI
REGRAMOSTIM SERPINE1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8260700

Sources:
NCI
REGRAMOSTIM BGLAP

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2655592

Sources:
NCI
REGRAMOSTIM RPS6KA3

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8662788

Sources:
NCI
REGRAMOSTIM BIRC5

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16403261

Sources:
NCI
REGRAMOSTIM CSF2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GVAX

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
REGRAMOSTIM TSHR

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12574393

Sources:
NCI
REGRAMOSTIM PIK3CA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15107457

Sources:
NCI

TdgClinicalTrial: GM-CSF
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class protein

FDA Approval not approved

Publications:

NCI: GM-CSF

Version: 14-September-2017

Alternate Names:

C1288 NCI drug code

Drug Info:

Publications:

Joseph et al., 1996, S6 kinase p90rsk in granulocyte-macrophage colony-stimulating factor-stimulated proliferative and mature hematopoietic cells., J. Biol. Chem.

Kikuchi et al., 2004, Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes., Int. Immunol.

Dogan et al., 2003, Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease., J. Immunol.

ChemblDrugs: chembl:CHEMBL2107881
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	DISC GM-CSF
Novel drug target	Established target
Trial Name	E75,N/

REGRAMOSTIM Drug Record

REGRAMOSTIM chembl:CHEMBL2107881 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12471017

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10792393

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9130550

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10379842

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12600815

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15126418

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name DISC GM-CSF Novel drug target Established target Trial Name E75,N/

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11591765

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8260700

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2655592

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8662788

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16403261

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name GVAX Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12574393

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15107457

Sources: NCI

TdgClinicalTrial: GM-CSF

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class protein FDA Approval not approved

Publications:

NCI: GM-CSF

Alternate Names: C1288 NCI drug code

Drug Info:

ChemblDrugs: chembl:CHEMBL2107881

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
12471017

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10792393

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9130550

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10379842

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12600815

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15126418

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name DISC GM-CSF

Novel drug target Established target

Trial Name E75,N/

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
11591765

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8260700

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2655592

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8662788

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16403261

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GVAX

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
12574393

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15107457

Sources:
NCI

Drug Info:

Drug Indications antineoplastic agent

Drug Class protein

FDA Approval not approved

Alternate Names:

C1288 NCI drug code