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REGRAMOSTIM Drug Record

  • Summary
  • Interactions
  • Claims
  • REGRAMOSTIM chembl:CHEMBL2107881 Antineoplastic

    Alternate Names:

    GM-CSF
    RHGM-CSF
    RHGM-C
    GMC-89-107
    REGRAMOSTIM
    GM-CSF (CHO CELL)

    Drug Info:

    Drug Indications antineoplastic agent,vaccine
    FDA Approval not approved
    Drug Class protein
    Drug Indications antineoplastic agent
    (0 More Sources)

    Publications:

    Joseph et al., 1996, S6 kinase p90rsk in granulocyte-macrophage colony-stimulating factor-stimulated proliferative and mature hematopoietic cells., J. Biol. Chem.
    Kikuchi et al., 2004, Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes., Int. Immunol.
    Hellmich et al., 2000, Granulocyte-macrophage colony-stimulating factor (GM-CSF) but not granulocyte colony-stimulating factor (G-CSF) induces plasma membrane expression of proteinase 3 (PR3) on neutrophils in vitro., Clin. Exp. Immunol.
    Hamilton et al., 1993, Macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor stimulate the synthesis of plasminogen-activator inhibitors by human monocytes., Blood
    Xue et al., 2005, [Factors regulating expression of antiapoptosis gene survivin]., Zhongguo Shi Yan Xue Ye Xue Za Zhi
    Jinquan et al., 2001, CXCR3 expression on CD34(+) hemopoietic progenitors induced by granulocyte-macrophage colony-stimulating factor: II. Signaling pathways involved., J. Immunol.
    Evans et al., 1989, The effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on human osteoblast-like cells., Biochem. Biophys. Res. Commun.
    Fuhler et al., 2004, Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia., J. Leukoc. Biol.
    Chen et al., 2003, GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-beta receptors., Am. J. Physiol. Lung Cell Mol. Physiol.
    Wong et al., 2003, Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-[kappa] B., Am. J. Respir. Cell Mol. Biol.
    Welker et al., GM-CSF downregulates expression of tryptase, Fc epsilon RI and histamine in HMC-1 mast cells., Int. Arch. Allergy Immunol.
    Dogan et al., 2003, Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease., J. Immunol.
    Savion et al., 1999, A possible role for granulocyte macrophage-colony stimulating factor in modulating teratogen-induced effects., Teratog., Carcinog. Mutagen.
  • REGRAMOSTIM   TGFBR3

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12471017


    Sources:
    NCI

  • REGRAMOSTIM   PRTN3

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10792393


    Sources:
    NCI

  • REGRAMOSTIM   TPSAB1

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9130550


    Sources:
    NCI

  • REGRAMOSTIM   CD5

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10379842


    Sources:
    NCI

  • REGRAMOSTIM   ICAM3

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12600815


    Sources:
    NCI

  • REGRAMOSTIM   TP73

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15126418


    Sources:
    NCI

  • REGRAMOSTIM   CSF2RA

    Interaction Score: 0.69

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name DISC GM-CSF
    Novel drug target Established target
    Trial Name E75,N/

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • REGRAMOSTIM   CXCL10

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11591765


    Sources:
    NCI

  • REGRAMOSTIM   SERPINE1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8260700


    Sources:
    NCI

  • REGRAMOSTIM   BGLAP

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2655592


    Sources:
    NCI

  • REGRAMOSTIM   RPS6KA3

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8662788


    Sources:
    NCI

  • REGRAMOSTIM   BIRC5

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16403261


    Sources:
    NCI

  • REGRAMOSTIM   CSF2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name GVAX
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • REGRAMOSTIM   TSHR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12574393


    Sources:
    NCI

  • REGRAMOSTIM   PIK3CA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15107457


    Sources:
    NCI

  • TdgClinicalTrial: GM-CSF

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class protein
    FDA Approval not approved

    Publications:

  • NCI: GM-CSF

    • Version: 14-September-2017

    Alternate Names:
    C1288 NCI drug code

    Drug Info:

    Publications:
    Joseph et al., 1996, S6 kinase p90rsk in granulocyte-macrophage colony-stimulating factor-stimulated proliferative and mature hematopoietic cells., J. Biol. Chem.
    Kikuchi et al., 2004, Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes., Int. Immunol.
    Dogan et al., 2003, Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease., J. Immunol.

  • ChemblDrugs: chembl:CHEMBL2107881

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21